Chemical Compound Review:
Epibatidine (4S,6S)-6-(6-chloropyridin-3- yl)-7...
Synonyms:
CHEBI:474798, LS-22333, PDSP2_000458, C11H13ClN2, AC1L2Y0E, ...
Hanning,
Blokland,
Johnson,
Perry,
Cucchiaro,
Chaijale,
Commons,
Hahn,
Sharples,
Wonnacott,
Shoaib,
Stolerman,
Ellis,
Harman,
Gonzalez,
Spera,
Liu,
Shen,
Wypij,
Zuo,
Prince,
Sine,
Belluardo,
Mudò,
Blum,
Cheng,
Caniglia,
Dell'Albani,
Fuxe,
Pakkanen,
Nousiainen,
Yli-Kauhaluoma,
Kylänlahti,
Möykkynen,
Korpi,
Peng,
Lukas,
Ahtee,
Tuominen,
Hama,
Lloyd,
Menzaghi,
Perry,
Martin-Ruiz,
Lee,
Griffiths,
Johnson,
Piggott,
Haroutunian,
Buxbaum,
Nãsland,
Davis,
Gotti,
Clementi,
Tzartos,
Cohen,
Soreq,
Jaros,
Perry,
Ballard,
McKeith,
Court,
Cucchiaro,
Chaijale,
Commons,
Abdrakhmanova,
Damaj,
Carroll,
Martin,
Khan,
Stanislaus,
Zhang,
Taylor,
Yaksh,
- Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists. Carroll, F.I., Ma, W., Yokota, Y., Lee, J.R., Brieaddy, L.E., Navarro, H.A., Damaj, M.I., Martin, B.R. J. Med. Chem. (2005)
- Nicotinic cholinergic receptors: potential targets for inflammatory pain relief. Lawand, N.B., Lu, Y., Westlund, K.N. Pain (1999)
- Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. Warpman, U., Friberg, L., Gillespie, A., Hellström-Lindahl, E., Zhang, X., Nordberg, A. J. Neurochem. (1998)
- Antihyperalgesic activity of epibatidine in the formalin model of facial pain. Gilbert, S.D., Clark, T.M., Flores, C.M. Pain (2001)
- Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype. Ellis, J.L., Harman, D., Gonzalez, J., Spera, M.L., Liu, R., Shen, T.Y., Wypij, D.M., Zuo, F. J. Pharmacol. Exp. Ther. (1999)
- Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine. Bonhaus, D.W., Bley, K.R., Broka, C.A., Fontana, D.J., Leung, E., Lewis, R., Shieh, A., Wong, E.H. J. Pharmacol. Exp. Ther. (1995)
- Attentional effects of nicotinic agonists in rats. Hahn, B., Sharples, C.G., Wonnacott, S., Shoaib, M., Stolerman, I.P. Neuropharmacology (2003)
- Human alpha 7 nicotinic acetylcholine receptor responses to novel ligands. Briggs, C.A., McKenna, D.G., Piattoni-Kaplan, M. Neuropharmacology (1995)
- Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases. Perry, E., Martin-Ruiz, C., Lee, M., Griffiths, M., Johnson, M., Piggott, M., Haroutunian, V., Buxbaum, J.D., Nãsland, J., Davis, K., Gotti, C., Clementi, F., Tzartos, S., Cohen, O., Soreq, H., Jaros, E., Perry, R., Ballard, C., McKeith, I., Court, J. Eur. J. Pharmacol. (2000)
- Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. Hansen, S.B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y. EMBO J. (2005)
- Identification of four classes of brain nicotinic receptors using beta2 mutant mice. Zoli, M., Léna, C., Picciotto, M.R., Changeux, J.P. J. Neurosci. (1998)
- Nicotinic receptor abnormalities in the cerebellar cortex in autism. Lee, M., Martin-Ruiz, C., Graham, A., Court, J., Jaros, E., Perry, R., Iversen, P., Bauman, M., Perry, E. Brain (2002)
- Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Jacobi, J., Jang, J.J., Sundram, U., Dayoub, H., Fajardo, L.F., Cooke, J.P. Am. J. Pathol. (2002)
- Effects of a novel cholinergic ion channel agonist SIB-1765F on locomotor activity in rats. Menzaghi, F., Whelan, K.T., Risbrough, V.B., Rao, T.S., Lloyd, G.K. J. Pharmacol. Exp. Ther. (1997)
- Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester. Dong, J.C., Wang, X., Li, R.T., Zhang, H.M., Cheng, T.M., Li, C.L. Bioorg. Med. Chem. Lett. (2003)
- Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. Tomizawa, M., Lee, D.L., Casida, J.E. J. Agric. Food Chem. (2000)
- Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models. Prince, R.J., Sine, S.M. J. Biol. Chem. (1999)
- Structural basis for epibatidine selectivity at desensitized nicotinic receptors. Pennington, R.A., Gao, F., Sine, S.M., Prince, R.J. Mol. Pharmacol. (2005)
- Epibatidine activates muscle acetylcholine receptors with unique site selectivity. Prince, R.J., Sine, S.M. Biophys. J. (1998)
- Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues. Wei, Z.L., Petukhov, P.A., Xiao, Y., Tückmantel, W., George, C., Kellar, K.J., Kozikowski, A.P. J. Med. Chem. (2003)
- Spinal nicotinic receptor expression in spontaneously hypertensive rats. Khan, I.M., Youngblood, K.L., Printz, M.P., Yaksh, T.L., Taylor, P. Hypertension (1996)
- 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mukhin, A.G., Gündisch, D., Horti, A.G., Koren, A.O., Tamagnan, G., Kimes, A.S., Chambers, J., Vaupel, D.B., King, S.L., Picciotto, M.R., Innis, R.B., London, E.D. Mol. Pharmacol. (2000)
- The locus coeruleus nucleus as a site of action of the antinociceptive and behavioral effects of the nicotinic receptor agonist, epibatidine. Cucchiaro, G., Chaijale, N., Commons, K.G. Neuropharmacology (2006)
- The dorsal raphe nucleus as a site of action of the antinociceptive and behavioral effects of the alpha4 nicotinic receptor agonist epibatidine. Cucchiaro, G., Chaijale, N., Commons, K.G. J. Pharmacol. Exp. Ther. (2005)
- Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors. Pakkanen, J.S., Nousiainen, H., Yli-Kauhaluoma, J., Kylänlahti, I., Möykkynen, T., Korpi, E.R., Peng, J.H., Lukas, R.J., Ahtee, L., Tuominen, R.K. J. Neurochem. (2005)
- exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: syntheses and nicotinic acetylcholine receptor agonist activity of potent pyridazine analogues of (+/-)-epibatidine. Che, D., Wegge, T., Stubbs, M.T., Seitz, G., Meier, H., Methfessel, C. J. Med. Chem. (2001)
- A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception. Khan, I.M., Stanislaus, S., Zhang, L., Taylor, P., Yaksh, T.L. J. Pharmacol. Exp. Ther. (2001)
- The nicotinic acetylcholine receptor agonist (+/-)-epibatidine increases FGF-2 mRNA and protein levels in the rat brain. Belluardo, N., Mudò, G., Blum, M., Cheng, Q., Caniglia, G., Dell'Albani, P., Fuxe, K. Brain Res. Mol. Brain Res. (1999)
- Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion. Del Signore, A., Gotti, C., De Stefano, M.E., Moretti, M., Paggi, P. Neurobiol. Dis. (2002)
- Effects of repeated anaesthesia on central cholinergic function in the rat cerebral cortex. Hanning, C.D., Blokland, A., Johnson, M., Perry, E.K. European journal of anaesthesiology. (2003)
- 2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine is a novel potent competitive antagonist of human neuronal alpha4beta2 nAChRs. Abdrakhmanova, G.R., Damaj, M.I., Carroll, F.I., Martin, B.R. Mol. Pharmacol. (2006)
- Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience. Moretti, M., Vailati, S., Zoli, M., Lippi, G., Riganti, L., Longhi, R., Viegi, A., Clementi, F., Gotti, C. Mol. Pharmacol. (2004)
- The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats. Hama, A.T., Lloyd, G.K., Menzaghi, F. Pain (2001)
- Neuronal nAChR stereoselectivity to non-natural epibatidine derivatives. Bertrand, S., Patt, J.T., Spang, J.E., Westera, G., Schubiger, P.A., Bertrand, D. FEBS Lett. (1999)