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Gene Review

MSRA  -  methionine sulfoxide reductase A

Homo sapiens

Synonyms: Mitochondrial peptide methionine sulfoxide reductase, PMSR, Peptide Met(O) reductase, Peptide-methionine (S)-S-oxide reductase, Protein-methionine-S-oxide reductase
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Disease relevance of MSRA


Psychiatry related information on MSRA


High impact information on MSRA


Biological context of MSRA


Anatomical context of MSRA


Associations of MSRA with chemical compounds


Other interactions of MSRA


Analytical, diagnostic and therapeutic context of MSRA


  1. Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina. Lee, J.W., Gordiyenko, N.V., Marchetti, M., Tserentsoodol, N., Sagher, D., Alam, S., Weissbach, H., Kantorow, M., Rodriguez, I.R. Exp. Eye Res. (2006) [Pubmed]
  2. An outbreak of methicillin-resistant Staphylococcus aureus in a large medical center. Gerken, M.V. The American surgeon. (1983) [Pubmed]
  3. Vancomycin therapy and the progression of methicillin-resistant Staphylococcus aureus vertebral osteomyelitis. Gelfand, M.S., Cleveland, K.O. South. Med. J. (2004) [Pubmed]
  4. Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress. Kantorow, M., Hawse, J.R., Cowell, T.L., Benhamed, S., Pizarro, G.O., Reddy, V.N., Hejtmancik, J.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. Huang, W., Escribano, J., Sarfarazi, M., Coca-Prados, M. Gene (1999) [Pubmed]
  6. Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain. Gabbita, S.P., Aksenov, M.Y., Lovell, M.A., Markesbery, W.R. J. Neurochem. (1999) [Pubmed]
  7. High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Ruan, H., Tang, X.D., Chen, M.L., Joiner, M.L., Sun, G., Brot, N., Weissbach, H., Heinemann, S.H., Iverson, L., Wu, C.F., Hoshi, T., Chen, M.L., Joiner, M.A., Heinemann, S.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Oxidative regulation of large conductance calcium-activated potassium channels. Tang, X.D., Daggett, H., Hanner, M., Garcia, M.L., McManus, O.B., Brot, N., Weissbach, H., Heinemann, S.H., Hoshi, T. J. Gen. Physiol. (2001) [Pubmed]
  9. The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation. Ogawa, F., Sander, C.S., Hansel, A., Oehrl, W., Kasperczyk, H., Elsner, P., Shimizu, K., Heinemann, S.H., Thiele, J.J. J. Invest. Dermatol. (2006) [Pubmed]
  10. Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1. Jung, S., Hansel, A., Kasperczyk, H., Hoshi, T., Heinemann, S.H. FEBS Lett. (2002) [Pubmed]
  11. Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium. Dhandayuthapani, S., Blaylock, M.W., Bebear, C.M., Rasmussen, W.G., Baseman, J.B. J. Bacteriol. (2001) [Pubmed]
  12. Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins. Hansel, A., Kuschel, L., Hehl, S., Lemke, C., Agricola, H.J., Hoshi, T., Heinemann, S.H. FASEB J. (2002) [Pubmed]
  13. Silencing of the methionine sulfoxide reductase A gene results in loss of mitochondrial membrane potential and increased ROS production in human lens cells. Marchetti, M.A., Lee, W., Cowell, T.L., Wells, T.M., Weissbach, H., Kantorow, M. Exp. Eye Res. (2006) [Pubmed]
  14. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. Schallreuter, K.U., Rübsam, K., Chavan, B., Zothner, C., Gillbro, J.M., Spencer, J.D., Wood, J.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  15. Enzymatic repair of oxidative damage to human apolipoprotein A-I. Sigalov, A.B., Stern, L.J. FEBS Lett. (1998) [Pubmed]
  16. Ablation of the mammalian methionine sulfoxide reductase A affects the expression level of cysteine deoxygenase. Oien, D.B., Moskovitz, J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  17. Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I. Sigalov, A.B., Stern, L.J. Antioxid. Redox Signal. (2002) [Pubmed]
  18. Genomic organization of the human PMS2 gene family. Nicolaides, N.C., Carter, K.C., Shell, B.K., Papadopoulos, N., Vogelstein, B., Kinzler, K.W. Genomics (1995) [Pubmed]
  19. Suppression of the TNFalpha-induced increase in IL-1alpha expression by hypochlorite in human corneal epithelial cells. Mohri, M., Reinach, P.S., Kanayama, A., Shimizu, M., Moskovitz, J., Hisatsune, T., Miyamoto, Y. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  20. Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds. Gladyshev, V.N. Proteins (2002) [Pubmed]
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