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Gene Review

GADD45B  -  growth arrest and DNA-damage-inducible, beta

Homo sapiens

Synonyms: DKFZP566B133, GADD45BETA, Growth arrest and DNA damage-inducible protein GADD45 beta, MYD118, Myeloid differentiation primary response protein MyD118, ...
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Disease relevance of GADD45B


High impact information on GADD45B

  • Mechanistic studies showed that sulfasalazine selectively blocks nuclear factor-kappaB-dependent gene transcription, inhibits hepatic stellate cell expression of Gadd45beta, stimulates phosphorylation of Jun N-terminal kinase 2, and promotes apoptosis by a mechanism that is prevented by the Jun N-terminal kinase inhibitor SP600125 [3].
  • The stress-inducible molecules GADD45beta and GADD45gamma have been implicated in regulating IFNgamma production in CD4 T cells [4].
  • The U(L)41 protein thus mediates two functions, i.e., it mediates rapid degradation of some mRNAs exemplified by beta-actin and stabilizes or delays the degradation of other mRNAs exemplified by GADD45beta, tristetraprolin, etc [5].
  • Here, we report that, in B cells, Gadd45 beta is induced by CD40 through a mechanism that requires NF-kappa B and that this induction suppresses Fas-mediated killing [6].
  • These findings identify Gadd45 beta as a critical mediator of the prosurvival response to CD40 stimulation and provide important new insights into the apoptotic mechanism that is triggered by Fas in B cells [6].

Biological context of GADD45B


Anatomical context of GADD45B


Regulatory relationships of GADD45B

  • Moreover, the TFPI-induced expression of GADD45B was blocked by receptor-associated protein, which masks the ligand-binding domain of very low density lipoprotein receptor (VLDL-R) [10].

Other interactions of GADD45B


Analytical, diagnostic and therapeutic context of GADD45B

  • By using DNA-array techniques and Northern blot analysis, we here revealed that TFPI transiently induced the mRNA expression of JUNB and GADD45B [10].
  • Histochemistry study and real-time PCR further confirmed that GADD45beta staining in HCC was significantly decreased when compared to surrounding non-neoplastic liver tissue [1].


  1. Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. Qiu, W., David, D., Zhou, B., Chu, P.G., Zhang, B., Wu, M., Xiao, J., Han, T., Zhu, Z., Wang, T., Liu, X., Lopez, R., Frankel, P., Jong, A., Yen, Y. Am. J. Pathol. (2003) [Pubmed]
  2. Antiapoptotic role of endogenous nitric oxide in human melanoma cells. Salvucci, O., Carsana, M., Bersani, I., Tragni, G., Anichini, A. Cancer Res. (2001) [Pubmed]
  3. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Oakley, F., Meso, M., Iredale, J.P., Green, K., Marek, C.J., Zhou, X., May, M.J., Millward-Sadler, H., Wright, M.C., Mann, D.A. Gastroenterology (2005) [Pubmed]
  4. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. Chi, H., Lu, B., Takekawa, M., Davis, R.J., Flavell, R.A. EMBO J. (2004) [Pubmed]
  5. The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs. Esclatine, A., Taddeo, B., Roizman, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Zazzeroni, F., Papa, S., Algeciras-Schimnich, A., Alvarez, K., Melis, T., Bubici, C., Majewski, N., Hay, N., De Smaele, E., Peter, M.E., Franzoso, G. Blood (2003) [Pubmed]
  7. Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. Wang, T., Hu, Y.C., Dong, S., Fan, M., Tamae, D., Ozeki, M., Gao, Q., Gius, D., Li, J.J. J. Biol. Chem. (2005) [Pubmed]
  8. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. Ijiri, K., Zerbini, L.F., Peng, H., Correa, R.G., Lu, B., Walsh, N., Zhao, Y., Taniguchi, N., Huang, X.L., Otu, H., Wang, H., Wang, J.F., Komiya, S., Ducy, P., Rahman, M.U., Flavell, R.A., Gravallese, E.M., Oettgen, P., Libermann, T.A., Goldring, M.B. J. Biol. Chem. (2005) [Pubmed]
  9. Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. Chen, Z., Clark, S., Birkeland, M., Sung, C.M., Lago, A., Liu, R., Kirkpatrick, R., Johanson, K., Winkler, J.D., Hu, E. Cancer Lett. (2002) [Pubmed]
  10. Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs. Shirotani-Ikejima, H., Kokame, K., Hamuro, T., Bu, G., Kato, H., Miyata, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. Strategic attack on host cell gene expression during adenovirus infection. Zhao, H., Granberg, F., Elfineh, L., Pettersson, U., Svensson, C. J. Virol. (2003) [Pubmed]
  12. Identification of a functional domain in a GADD45-mediated G2/M checkpoint. Yang, Q., Manicone, A., Coursen, J.D., Linke, S.P., Nagashima, M., Forgues, M., Wang, X.W. J. Biol. Chem. (2000) [Pubmed]
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