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Gene Review

ROR1  -  receptor tyrosine kinase-like orphan...

Homo sapiens

Synonyms: NTRKR1, Neurotrophic tyrosine kinase, receptor-related 1, Tyrosine-protein kinase transmembrane receptor ROR1, dJ537F10.1
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Disease relevance of ROR1


High impact information on ROR1


Biological context of ROR1


Anatomical context of ROR1


Associations of ROR1 with chemical compounds

  • We have cloned cDNA encoding a mouse nuclear receptor mROR alpha which is a homolog of human retinoic acid receptor-related orphan receptor (hROR alpha) [7].

Other interactions of ROR1

  • ROR2 promoter rather than ROR1 promoter was more evolutionarily conserved [1].

Analytical, diagnostic and therapeutic context of ROR1


  1. Comparative genomics on ROR1 and ROR2 orthologs. Katoh, M., Katoh, M. Oncol. Rep. (2005) [Pubmed]
  2. Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. Reddy, U.R., Phatak, S., Pleasure, D. Oncogene (1996) [Pubmed]
  3. ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis. Xia, R., Wang, J., Liu, C., Wang, Y., Wang, Y., Zhai, J., Liu, J., Hong, X., Cao, X., Zhu, J.K., Gong, Z. Plant Cell (2006) [Pubmed]
  4. Activation of a delayed-early gene encoding MHR3 by the ecdysone receptor heterodimer EcR-B1-USP-1 but not by EcR-B1-USP-2. Lan, Q., Hiruma, K., Hu, X., Jindra, M., Riddiford, L.M. Mol. Cell. Biol. (1999) [Pubmed]
  5. Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis. Reddy, U.R., Phatak, S., Allen, C., Nycum, L.M., Sulman, E.P., White, P.S., Biegel, J.A. Genomics (1997) [Pubmed]
  6. Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. Paganoni, S., Ferreira, A. J. Cell. Sci. (2005) [Pubmed]
  7. An orphan nuclear receptor, mROR alpha, and its spatial expression in adult mouse brain. Matsui, T., Sashihara, S., Oh, Y., Waxman, S.G. Brain Res. Mol. Brain Res. (1995) [Pubmed]
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