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Gene Review

LEP  -  leptin

Felis catus

 
 
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Disease relevance of LEP

  • Neutering induces changes in food intake, body weight, plasma insulin and leptin concentrations in normal and lipoprotein lipase-deficient male cats [1].
  • CONCLUSIONS AND CLINICAL RELEVANCE: Changes in NEFA suppression, caloric intake, and leptin concentrations may be indicators of, and possible risk factors for, the development of obesity in cats after neutering [2].
  • After feeding the test meal to overweight cats in the early morning, plasma leptin concentrations initially decreased before subsequently rising to peak 15 h later, which coincided with late evening [3].
  • In the second part of the study, plasma leptin concentrations were determined in 16 cats before and after approximately 10 months of spontaneous weight gain [4].
 

High impact information on LEP

 

Chemical compound and disease context of LEP

  • After gonadectomy, plasma concentrations of glucose and triacylglycerol did not change, whereas plasma insulin and leptin concentrations increased (P < 0.05), but not coincidentally with body weight gain [8].
  • This study investigated relationships between plasma leptin, insulin concentrations, insulin sensitivity and glucose tolerance in lean and overweight cats [3].
 

Biological context of LEP

 

Anatomical context of LEP

 

Associations of LEP with chemical compounds

 

Analytical, diagnostic and therapeutic context of LEP

References

  1. Neutering induces changes in food intake, body weight, plasma insulin and leptin concentrations in normal and lipoprotein lipase-deficient male cats. Kanchuk, M.L., Backus, R.C., Calvert, C.C., Morris, J.G., Rogers, Q.R. J. Nutr. (2002) [Pubmed]
  2. Effects of neutering on hormonal concentrations and energy requirements in male and female cats. Hoenig, M., Ferguson, D.C. Am. J. Vet. Res. (2002) [Pubmed]
  3. Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats. Appleton, D.J., Rand, J.S., Sunvold, G.D. J. Feline Med. Surg. (2002) [Pubmed]
  4. Plasma leptin concentrations in cats: reference range, effect of weight gain and relationship with adiposity as measured by dual energy X-ray absorptiometry. Appleton, D.J., Rand, J.S., Sunvold, G.D. J. Feline Med. Surg. (2000) [Pubmed]
  5. Effects of interactions between interleukin-1 beta and leptin on cat intestinal vagal mechanoreceptors. Gaigé, S., Abou, E., Abysique, A., Bouvier, M. J. Physiol. (Lond.) (2004) [Pubmed]
  6. Effects of leptin on cat intestinal motility. Gaigé, S., Abysique, A., Bouvier, M. J. Physiol. (Lond.) (2003) [Pubmed]
  7. Effects of leptin on cat intestinal vagal mechanoreceptors. Gaigé, S., Abysique, A., Bouvier, M. J. Physiol. (Lond.) (2002) [Pubmed]
  8. Weight gain in gonadectomized normal and lipoprotein lipase-deficient male domestic cats results from increased food intake and not decreased energy expenditure. Kanchuk, M.L., Backus, R.C., Calvert, C.C., Morris, J.G., Rogers, Q.R. J. Nutr. (2003) [Pubmed]
  9. Leptin, body fat content and energy expenditure in intact and gonadectomized adult cats: a preliminary study. Martin, L., Siliart, B., Dumon, H., Backus, R., Biourge, V., Nguyen, P. Journal of animal physiology and animal nutrition. (2001) [Pubmed]
  10. Relationship between serum leptin immunoreactivity and body fat mass as estimated by use of a novel gas-phase Fourier transform infrared spectroscopy deuterium dilution method in cats. Backus, R.C., Havel, P.J., Gingerich, R.L., Rogers, Q.R. Am. J. Vet. Res. (2000) [Pubmed]
  11. CDNA cloning of feline leptin and its mRNA expression in adipose tissue. Sasaki, N., Shibata, H., Honjoh, T., Kimura, K., Saito, M., Ohishi, I. J. Vet. Med. Sci. (2001) [Pubmed]
  12. Effect of darglitazone on glucose clearance and lipid metabolism in obese cats. Hoenig, M., Ferguson, D.C. Am. J. Vet. Res. (2003) [Pubmed]
 
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