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Gene Review

Nrcam  -  neuronal cell adhesion molecule

Rattus norvegicus

Synonyms: Ankyrin-binding cell adhesion molecule NrCAM, Neuronal cell adhesion molecule, Neuronal surface protein Bravo, Ng-CAM-related, NgCAM-related cell adhesion molecule, ...
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Disease relevance of Nrcam


Psychiatry related information on Nrcam

  • These observations support NrCAM as a positionally cloned and drug-regulated gene whose variants are likely to change expression and alter substance abuse vulnerabilities in human addictions and animal models of drug reward [3].

High impact information on Nrcam

  • Furthermore, both neurofascin and the related molecule Nr-CAM are tyrosine phosphorylated in a developmentally regulated pattern in rat brain [4].
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments [5].
  • NrCAM coupling to the cytoskeleton depends on multiple protein domains and partitioning into lipid rafts [1].
  • Next, we showed that the actin-dependent retrograde movement of NrCAM required partitioning into lipid rafts as indicated by cholesterol depletion experiments using methyl-beta-cyclodextrin [1].
  • Nr-Fc had no effect on initial axon-Schwann cell interactions, including Schwann cell proliferation, or on the extent of myelination, but it strikingly and specifically inhibited Na(+) channel and ankyrin G accumulation at the node [2].

Biological context of Nrcam

  • Neurone glial-related cell adhesion molecule (NrCAM) is a member of the L1 family of transmembrane cell adhesion receptors which are involved in the development and function of the mammalian nervous system [6].
  • NrCAM displays haplotype-specific gene expression in human post-mortem brain samples [3].
  • Fine mapping within a chromosome 7 region that contains previously linked and associated genomic markers identifies NrCAM haplotypes that are associated with substance abuse vulnerabilities in four samples of abusers and controls [3].
  • Furthermore Nr-CAM, which is widely expressed in the cerebellum during embryonic development, becomes strictly confined to Purkinje and Golgi cells in postnatal cerebellum, suggesting a possible role of Nr-CAM for the maturation or stabilization of the synaptic contacts, in particular between climbing fibers and Purkinje cells [7].

Anatomical context of Nrcam

  • Additionally, NrCAM constructs whose last three amino acids had been deleted appeared to have a dominant negative effect on neurite extension of cerebellar granule cells [6].
  • NrCAM, visualized with antibodies specific for the ecto-domain, also was found to be coexpressed with neurofascin at nodes of Ranvier and at axon initial segments [5].

Physical interactions of Nrcam


Other interactions of Nrcam

  • This is the first interaction reported for NrCAM, and its association with SAP102 suggests that it is part of a larger complex which can interact with many different signalling pathways [6].


  1. NrCAM coupling to the cytoskeleton depends on multiple protein domains and partitioning into lipid rafts. Falk, J., Thoumine, O., Dequidt, C., Choquet, D., Faivre-Sarrailh, C. Mol. Biol. Cell (2004) [Pubmed]
  2. Nr-CAM and neurofascin interactions regulate ankyrin G and sodium channel clustering at the node of Ranvier. Lustig, M., Zanazzi, G., Sakurai, T., Blanco, C., Levinson, S.R., Lambert, S., Grumet, M., Salzer, J.L. Curr. Biol. (2001) [Pubmed]
  3. NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Ishiguro, H., Liu, Q.R., Gong, J.P., Hall, F.S., Ujike, H., Morales, M., Sakurai, T., Grumet, M., Uhl, G.R. Neuropsychopharmacology (2006) [Pubmed]
  4. Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. Garver, T.D., Ren, Q., Tuvia, S., Bennett, V. J. Cell Biol. (1997) [Pubmed]
  5. Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. Davis, J.Q., Lambert, S., Bennett, V. J. Cell Biol. (1996) [Pubmed]
  6. Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule. Davey, F., Hill, M., Falk, J., Sans, N., Gunn-Moore, F.J. J. Neurochem. (2005) [Pubmed]
  7. Nr-CAM and TAG-1 are expressed in distinct populations of developing precerebellar and cerebellar neurons. Backer, S., Sakurai, T., Grumet, M., Sotelo, C., Bloch-Gallego, E. Neuroscience (2002) [Pubmed]
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