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Gene Review

RDH11  -  retinol dehydrogenase 11 (all-trans/9...

Homo sapiens

Synonyms: ARSDR1, Androgen-regulated short-chain dehydrogenase/reductase 1, CGI-82, CGI82, HCBP12, ...
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Disease relevance of RDH11

  • This study identified a novel gene that we have designated prostate short-chain dehydrogenase/reductase 1 (PSDR1), that exhibits increased expression on exposure to androgens in the LNCaP prostate cancer cell line [1].

High impact information on RDH11


Biological context of RDH11


Anatomical context of RDH11

  • In the present study, we purified the recombinant enzyme from the microsomal membranes of insect Sf9 cells, determined its catalytic efficiency for the reduction of retinal and the oxidation of retinol, established its transmembrane topology, and examined the distribution of RalR1 in human tissues and cell lines [5].
  • Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues [6].
  • Psdr1 was cloned as a 3.2 kbp transcript from mouse testis cDNA based on the sequence of the recently described androgen-regulated human PSDR1 gene (Cancer Res. 61 (2001) 1611) [7].

Associations of RDH11 with chemical compounds


Other interactions of RDH11


Analytical, diagnostic and therapeutic context of RDH11


  1. Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium. Lin, B., White, J.T., Ferguson, C., Wang, S., Vessella, R., Bumgarner, R., True, L.D., Hood, L., Nelson, P.S. Cancer Res. (2001) [Pubmed]
  2. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. Haeseleer, F., Jang, G.F., Imanishi, Y., Driessen, C.A., Matsumura, M., Nelson, P.S., Palczewski, K. J. Biol. Chem. (2002) [Pubmed]
  3. Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). Kedishvili, N.Y., Chumakova, O.V., Chetyrkin, S.V., Belyaeva, O.V., Lapshina, E.A., Lin, D.W., Matsumura, M., Nelson, P.S. J. Biol. Chem. (2002) [Pubmed]
  4. Crystal structure of the vertebrate NADP(H)-dependent alcohol dehydrogenase (ADH8). Rosell, A., Valencia, E., Parés, X., Fita, I., Farrés, J., Ochoa, W.F. J. Mol. Biol. (2003) [Pubmed]
  5. Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines. Belyaeva, O.V., Stetsenko, A.V., Nelson, P., Kedishvili, N.Y. Biochemistry (2003) [Pubmed]
  6. Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. Belyaeva, O.V., Kedishvili, N.Y. FEBS Lett. (2002) [Pubmed]
  7. Isolation and characterization of the murine prostate short-chain dehydrogenase/reductase 1 (Psdr1) gene, a new member of the short-chain steroid dehydrogenase/reductase family. Moore, S., Pritchard, C., Lin, B., Ferguson, C., Nelson, P.S. Gene (2002) [Pubmed]
  8. Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. Gallego, O., Belyaeva, O.V., Porté, S., Ruiz, F.X., Stetsenko, A.V., Shabrova, E.V., Kostereva, N.V., Farrés, J., Parés, X., Kedishvili, N.Y. Biochem. J. (2006) [Pubmed]
  9. Burns in patients with epilepsy: changes in epidemiology and implications for burn treatment and prevention. Josty, I.C., Narayanan, V., Dickson, W.A. Epilepsia (2000) [Pubmed]
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