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Gene Review

AKR1B10  -  aldo-keto reductase family 1, member B10...

Homo sapiens

Synonyms: AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, ...
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Disease relevance of AKR1B10


Psychiatry related information on AKR1B10

  • AIMS: To assess the validity of the Fagerström test for nicotine dependence (FTND, six items) and of a short-form of this questionnaire, the Heaviness of Smoking Index (HSI, two items), in a population of relatively light smokers [4].
  • MEASUREMENTS: French-language versions of the FTND and HSI, smoking status, saliva cotinine level, self-efficacy for quitting smoking and other variables related to addiction with cigarettes [4].

High impact information on AKR1B10


Chemical compound and disease context of AKR1B10


Biological context of AKR1B10


Anatomical context of AKR1B10


Associations of AKR1B10 with chemical compounds

  • In addition to its reducing activity, AKR1B10 catalyzed the NADP+-dependent oxidation of the secondary alcohol (S)-1-indanol to 1-indanone with high enzymatic efficiency (kcat/Km=112 mM-1 min-1) [12].
  • ADHs appear to be more effective retinol dehydrogenases than SDRs because of their higher kcat values, whereas RDH11 and AKR1B10 are efficient retinaldehyde reductases [21].
  • Human AR and HSI AR were very efficient in the reduction of all- trans -, 9- cis - and 13- cis -retinal ( k (cat)/ K (m)=1100-10300 mM(-1).min(-1)), constituting the first cytosolic NADP(H)-dependent retinal reductases described in humans [22].
  • We found that both SR transcript and activity increased in parallel with a remarkable decline in aldose reductase-like enzyme activity when BH4 increased transiently in the early development [23].
  • The HSI provides an osmotic and volume stimulus, whereas the ISO infusion provides a volume-only stimulus [24].

Other interactions of AKR1B10


Analytical, diagnostic and therapeutic context of AKR1B10


  1. Identification and characterization of a novel human aldose reductase-like gene. Cao, D., Fan, S.T., Chung, S.S. J. Biol. Chem. (1998) [Pubmed]
  2. AKR1B10: a new diagnostic marker of non-small cell lung carcinoma in smokers. Penning, T.M. Clin. Cancer Res. (2005) [Pubmed]
  3. Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas. Fukumoto, S., Yamauchi, N., Moriguchi, H., Hippo, Y., Watanabe, A., Shibahara, J., Taniguchi, H., Ishikawa, S., Ito, H., Yamamoto, S., Iwanari, H., Hironaka, M., Ishikawa, Y., Niki, T., Sohara, Y., Kodama, T., Nishimura, M., Fukayama, M., Dosaka-Akita, H., Aburatani, H. Clin. Cancer Res. (2005) [Pubmed]
  4. Validity of the Fagerström test for nicotine dependence and of the Heaviness of Smoking Index among relatively light smokers. Etter, J.F., Duc, T.V., Perneger, T.V. Addiction (1999) [Pubmed]
  5. Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo-inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells. Thomas, T.P., Porcellati, F., Kato, K., Stevens, M.J., Sherman, W.R., Greene, D.A. J. Clin. Invest. (1994) [Pubmed]
  6. An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein. Bartels, D., Engelhardt, K., Roncarati, R., Schneider, K., Rotter, M., Salamini, F. EMBO J. (1991) [Pubmed]
  7. Specification of unique Pit-1 activity in the hGH locus control region. Shewchuk, B.M., Liebhaber, S.A., Cooke, N.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions. Shewchuk, B.M., Ho, Y., Liebhaber, S.A., Cooke, N.E. Mol. Cell. Biol. (2006) [Pubmed]
  9. Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein. Vidal, H., Mondesert, G., Galiègue, S., Carrière, D., Dupuy, P.H., Carayon, P., Combes, T., Bribes, E., Simony-Lafontaine, J., Kramar, A., Loison, G., Casellas, P. Cancer Res. (2003) [Pubmed]
  10. Risk factors for radial artery harvest site infection following coronary artery bypass graft surgery. Trick, W.E., Scheckler, W.E., Tokars, J.I., Jones, K.C., Smith, E.M., Reppen, M.L., Jarvis, W.R. Clin. Infect. Dis. (2000) [Pubmed]
  11. APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic. Bennett, R.P., Diner, E., Sowden, M.P., Lees, J.A., Wedekind, J.E., Smith, H.C. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  12. Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics. Martin, H.J., Breyer-Pfaff, U., Wsol, V., Venz, S., Block, S., Maser, E. Drug Metab. Dispos. (2006) [Pubmed]
  13. Glucose inhibition of human fibroblast proliferation and response to growth factors is prevented by inhibitors of aldose reductase. Sibbitt, W.L., Mills, R.G., Bigler, C.F., Eaton, R.P., Griffey, R.H., Vander Jagt, D.L. Mech. Ageing Dev. (1989) [Pubmed]
  14. Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses. Grisaru, D., Pick, M., Perry, C., Sklan, E.H., Almog, R., Goldberg, I., Naparstek, E., Lessing, J.B., Soreq, H., Deutsch, V. J. Immunol. (2006) [Pubmed]
  15. Developmentally regulated and erythroid-specific expression of the human embryonic beta-globin gene in transgenic mice. Shih, D.M., Wall, R.J., Shapiro, S.G. Nucleic Acids Res. (1990) [Pubmed]
  16. Adrenocorticotropin-dependent changes in SF-1/DAX-1 ratio influence steroidogenic genes expression in a novel model of glucocorticoid-producing adrenocortical cell lines derived from targeted tumorigenesis. Ragazzon, B., Lefrançois-Martinez, A.M., Val, P., Sahut-Barnola, I., Tournaire, C., Chambon, C., Gachancard-Bouya, J.L., Begue, R.J., Veyssière, G., Martinez, A. Endocrinology (2006) [Pubmed]
  17. Product of side-chain cleavage of cholesterol, isocaproaldehyde, is an endogenous specific substrate of mouse vas deferens protein, an aldose reductase-like protein in adrenocortical cells. Lefrançois-Martinez, A.M., Tournaire, C., Martinez, A., Berger, M., Daoudal, S., Tritsch, D., Veyssière, G., Jean, C. J. Biol. Chem. (1999) [Pubmed]
  18. Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland. Lau, E.T., Cao, D., Lin, C., Chung, S.K., Chung, S.S. Biochem. J. (1995) [Pubmed]
  19. Evolution of the aldose reductase-related gecko eye lens protein rhoB-crystallin: a sheep in wolf's clothing. van Boekel, M.A., van Aalten, D.M., Caspers, G.J., Röll, B., de Jong, W.W. J. Mol. Evol. (2001) [Pubmed]
  20. Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium. Sousa, A.R., Lane, S.J., Nakhosteen, J.A., Lee, T.H., Poston, R.N. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  21. Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. Gallego, O., Belyaeva, O.V., Porté, S., Ruiz, F.X., Stetsenko, A.V., Shabrova, E.V., Kostereva, N.V., Farrés, J., Parés, X., Kedishvili, N.Y. Biochem. J. (2006) [Pubmed]
  22. Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism. Crosas, B., Hyndman, D.J., Gallego, O., Martras, S., Parés, X., Flynn, T.G., Farrés, J. Biochem. J. (2003) [Pubmed]
  23. Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2. Choi, Y.K., Kong, J.S., Park, Y.S. Biochim. Biophys. Acta (2006) [Pubmed]
  24. Sympathetic neural responses to increased osmolality in humans. Farquhar, W.B., Wenner, M.M., Delaney, E.P., Prettyman, A.V., Stillabower, M.E. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  25. Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers. Woenckhaus, M., Klein-Hitpass, L., Grepmeier, U., Merk, J., Pfeifer, M., Wild, P., Bettstetter, M., Wuensch, P., Blaszyk, H., Hartmann, A., Hofstaedter, F., Dietmaier, W. J. Pathol. (2006) [Pubmed]
  26. Proteomics in human disease: cancer, heart and infectious diseases. Jungblut, P.R., Zimny-Arndt, U., Zeindl-Eberhart, E., Stulik, J., Koupilova, K., Pleissner, K.P., Otto, A., Müller, E.C., Sokolowska-Köhler, W., Grabher, G., Stöffler, G. Electrophoresis (1999) [Pubmed]
  27. Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene. Bennani-Baïti, I.M., Cooke, N.E., Liebhaber, S.A. Genomics (1998) [Pubmed]
  28. ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities. Grisaru, D., Deutsch, V., Shapira, M., Pick, M., Sternfeld, M., Melamed-Book, N., Kaufer, D., Galyam, N., Gait, M.J., Owen, D., Lessing, J.B., Eldor, A., Soreq, H. Mol. Med. (2001) [Pubmed]
  29. Proteoglycans from human umbilical vein endothelial cells. Griesmacher, A., Hennes, R., Keller, R., Greiling, H. Eur. J. Biochem. (1987) [Pubmed]
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