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Gene Review

ARMCX1  -  armadillo repeat containing, X-linked 1

Homo sapiens

Synonyms: AD032, ALEX1, ARM protein lost in epithelial cancers on chromosome X 1, Armadillo repeat-containing X-linked protein 1, GASP7, ...
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Disease relevance of ARMCX1

  • ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas [1].
  • Expression of ALEX1 and ALEX2 mRNA is lost or significantly reduced in human lung, prostate, colon, pancreas, and ovarian carcinomas and also in cell lines established from different human carcinomas [1].
  • Here, Christopher Marguerie, Claudio Lunardi and Alex So summarize and interpret the most recent findings and describe the current understanding of TCR usage in autoimmune diseases [2].
  • Case Alex, with Sturge-Weber Syndrome affecting the left hemisphere, failed to develop speech throughout early boyhood, and his comprehension of single words and simple commands remained stagnant at an age equivalent of 3-4 years [3].
  • Since Alex cells contain an integrated hepatitis B virus genome and secrete hepatitis B surface antigen (HBsAg), the serum HBsAg concentration in tumor-bearing mice was used to quantitate tumor burden [4].

Psychiatry related information on ARMCX1

  • Alex Rubino on the personality correlates of alexithymia implied that there are several important areas for further discussion [5].

High impact information on ARMCX1

  • Here, Toshiko Sakihama, Alex Smolyar and Ellis Reinherz discuss the molecular nature of CD4-MHC class II clustering and how, despite each of the component interactions being of low affinity, the molecular matrix renders T-cell recognition extremely specific and sensitive [6].
  • METHODS: Farmers' and nonfarmers' children living in rural areas in Austria and Germany and who were enrolled in the cross-sectional ALEX study were genotyped for single nucleotide polymorphisms in the TLR2 and TLR4 genes [7].
  • Alex 0.5 cells were 25-, 14-, and 1.4-fold more resistant to doxorubicin, vinblastine, and cis-platinum, respectively [4].
  • Furthermore, another anti-beta 1 mAb, Alex 1/4, which binds to a different epitope on the beta 1 molecule and was unable to block Fn binding, did not affect T. cruzi invasion [8].
  • Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nevus of Ota treatment [9].

Biological context of ARMCX1


Anatomical context of ARMCX1

  • 2. ALEX1 and ALEX2 transcripts are found in all human tissues examined except peripheral blood leukocytes [1].
  • We developed a new bioreactor design (ALEX), associated with a new extracellular autologous hepatocyte biomatrix (Porcine Autologous Biomatrix - PBM) support [15].

Associations of ARMCX1 with chemical compounds

  • Aldosterone levels significantly increased after both i.v. ALEX doses, but not after HEX [16].
  • The ACTH and cortisol responses to the highest ALEX dose were significantly higher than those after HEX [16].
  • SOM-Al model, approved by using Alex instead of organically bound aluminium (i.e., Alp and Alcu), could depict the changes in Al activities most successfully [17].
  • The educational efforts of American dermatologists such as Dr. Alex Fisher have helped lead to the deletion of ethylenediamine from Mycolog cream [18].
  • Dr Alex Gatherer, Oxfordshire AHA(T) area medical officer, with the help of Katrina Bishop and Alexandre Kalache, a clinical lecturer in community medicine at Oxford University, tried to answer these and other questions [19].

Other interactions of ARMCX1

  • The genes encoding ALEX1, ALEX2 and ALEX3 co-localize to the same region in Xq21.33-q22 [1].

Analytical, diagnostic and therapeutic context of ARMCX1

  • Here, Alex Chen and colleagues review current progress in the field of vascular NOS gene transfer and the potential use of NOS gene therapy for a number of cardiovascular diseases [20].
  • RESULTS: The immediate pain after treatment was more severe for QS Alex than for QS Nd:YAG laser [21].
  • Alex Black, a staff nurse on an intensive care unit, was extremely concerned about the lack of adequate staffing levels on the unit [22].


  1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Kurochkin, I.V., Yonemitsu, N., Funahashi, S.I., Nomura, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. PCR-based analysis of the TCR repertoire in human autoimmune diseases. Marguerie, C., Lunardi, C., So, A. Immunol. Today (1992) [Pubmed]
  3. Onset of speech after left hemispherectomy in a nine-year-old boy. Vargha-Khadem, F., Carr, L.J., Isaacs, E., Brett, E., Adams, C., Mishkin, M. Brain (1997) [Pubmed]
  4. Establishment and serial quantification of intrahepatic xenografts of human hepatocellular carcinoma in severe combined immunodeficiency mice, and development of therapeutic strategies to overcome multidrug resistance. Leveille-Webster, C.R., Arias, I.A. Clin. Cancer Res. (1996) [Pubmed]
  5. Sociocultural differences on hostility in alexithymic persons. Fukunishi, I., Hosaka, T., Berger, D. Psychological reports. (1995) [Pubmed]
  6. Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules. Sakihama, T., Smolyar, A., Reinherz, E.L. Immunol. Today (1995) [Pubmed]
  7. Toll-like receptor 2 as a major gene for asthma in children of European farmers. Eder, W., Klimecki, W., Yu, L., von Mutius, E., Riedler, J., Braun-Fahrländer, C., Nowak, D., Martinez, F.D. J. Allergy Clin. Immunol. (2004) [Pubmed]
  8. Involvement of beta 1 integrins in the binding and entry of Trypanosoma cruzi into human macrophages. Fernández, M.A., Muñoz-Fernández, M.A., Fresno, M. Eur. J. Immunol. (1993) [Pubmed]
  9. Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nevus of Ota treatment. Chan, H.H., Lam, L.K., Wong, D.S., Wei, W.I. Lasers in surgery and medicine. (2003) [Pubmed]
  10. Toxicology: studies in drug safety. Interview by Alex Robinson. Morton, D. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1994) [Pubmed]
  11. Alex Comfort's biology of ontology: implications for gerontology, phenomenology and the philosophy of science. Wheeler, H. Exp. Gerontol. (1998) [Pubmed]
  12. Association between exposure to farming, allergies and genetic variation in CARD4/NOD1. Eder, W., Klimecki, W., Yu, L., von Mutius, E., Riedler, J., Braun-Fahrländer, C., Nowak, D., Holst, O., Martinez, F.D. Allergy (2006) [Pubmed]
  13. Oscillating evolution of a mammalian locus with overlapping reading frames: an XLalphas/ALEX relay. Nekrutenko, A., Wadhawan, S., Goetting-Minesky, P., Makova, K.D. PLoS Genet. (2005) [Pubmed]
  14. Environmental health: in the wake of the Braer. Interview by Alex Mathieson. Cook, L. Nursing standard (Royal College of Nursing (Great Britain) : 1987) (1993) [Pubmed]
  15. ALEX (artificial liver for extracorporeal xenoassistance): a new bioreactor containing a porcine autologous biomatrix as hepatocyte support. Preliminary results in an ex vivo experimental model. Ambrosino, G., Varotto, S., Basso, S., Galavotti, D., Cecchetto, A., Carraro, P., Naso, A., De Silvestro, G., Plebani, M., Giron, G., Abatangelo, G., Donato, D., Braga, G.P., Cestrone, A., Marrelli, L., Trombetta, M., Lorenzelli, V., Picardi, A., Valente, M.L., Palu, G., Colantoni, A., Van Thiel, D., Ricordi, C., D'Amico, D.F. The International journal of artificial organs. (2002) [Pubmed]
  16. Endocrine activities of alexamorelin (Ala-His-d-2-methyl-Trp-Ala-Trp-d-Phe-Lys-NH2), a synthetic GH secretagogue, in humans. Broglio, F., Benso, A., Gottero, C., Muccioli, G., Deghenghi, R., Ghigo, E., Arvat, E. Eur. J. Endocrinol. (2000) [Pubmed]
  17. Aluminium mobilization from acidic forest soils in Leigongshan area, Southwestern China: Laboratory and field study. Guo, J., Vogt, R.D., Zhang, X., Zhang, Y., Seip, H.M., Xiao, J., Tang, H. Arch. Environ. Contam. Toxicol. (2006) [Pubmed]
  18. Allergic contact dermatitis to ethylenediamine. A continuing problem. Hogan, D.J. Dermatologic clinics. (1990) [Pubmed]
  19. Community hospitals: cornerstone of care for the future health service. Gatherer, A., Bishop, K., Kalache, A. Health and social service journal. (1980) [Pubmed]
  20. Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system. Chen, A.F., O'Brien, T., Katusic, Z.S. Trends Pharmacol. Sci. (1998) [Pubmed]
  21. In vivo trial comparing patients' tolerance of Q-switched Alexandrite (QS Alex) and Q-switched neodymium:yttrium-aluminum-garnet (QS Nd:YAG) lasers in the treatment of nevus of Ota. Chan, H.H., King, W.W., Chan, E.S., Mok, C.O., Ho, W.S., Van Krevel, C., Lau, W.Y. Lasers in surgery and medicine. (1999) [Pubmed]
  22. Confidentiality. 9: The law relating to whistle blowing. Dimond, B. British journal of nursing (Mark Allen Publishing) (1999) [Pubmed]
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