Disease relevance of ARMCX1

• ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas [1].
• Expression of ALEX1 and ALEX2 mRNA is lost or significantly reduced in human lung, prostate, colon, pancreas, and ovarian carcinomas and also in cell lines established from different human carcinomas [1].
• Here, Christopher Marguerie, Claudio Lunardi and Alex So summarize and interpret the most recent findings and describe the current understanding of TCR usage in autoimmune diseases [2].
• Case Alex, with Sturge-Weber Syndrome affecting the left hemisphere, failed to develop speech throughout early boyhood, and his comprehension of single words and simple commands remained stagnant at an age equivalent of 3-4 years [3].
• Since Alex cells contain an integrated hepatitis B virus genome and secrete hepatitis B surface antigen (HBsAg), the serum HBsAg concentration in tumor-bearing mice was used to quantitate tumor burden [4].

Psychiatry related information on ARMCX1

• Alex Rubino on the personality correlates of alexithymia implied that there are several important areas for further discussion [5].

High impact information on ARMCX1

• Here, Toshiko Sakihama, Alex Smolyar and Ellis Reinherz discuss the molecular nature of CD4-MHC class II clustering and how, despite each of the component interactions being of low affinity, the molecular matrix renders T-cell recognition extremely specific and sensitive [6].
• METHODS: Farmers' and nonfarmers' children living in rural areas in Austria and Germany and who were enrolled in the cross-sectional ALEX study were genotyped for single nucleotide polymorphisms in the TLR2 and TLR4 genes [7].
• Alex 0.5 cells were 25-, 14-, and 1.4-fold more resistant to doxorubicin, vinblastine, and cis-platinum, respectively [4].
• Furthermore, another anti-beta 1 mAb, Alex 1/4, which binds to a different epitope on the beta 1 molecule and was unable to block Fn binding, did not affect T. cruzi invasion [8].
• Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nevus of Ota treatment [9].

Biological context of ARMCX1

• Toxicology: studies in drug safety. Interview by Alex Robinson [10].
• Alex Comfort's biology of ontology: implications for gerontology, phenomenology and the philosophy of science [11].
• METHODS: We genotyped 668 children [mean age 9.3 (SD 1.5) years] enrolled in the cross-sectional ALEX study for seven haplotype tagging single nucleotide polymorphisms in CARD4 [12].
• Oscillating evolution of a mammalian locus with overlapping reading frames: an XLalphas/ALEX relay [13].
• Environmental health: in the wake of the Braer. Interview by Alex Mathieson [14].

Anatomical context of ARMCX1

• 2. ALEX1 and ALEX2 transcripts are found in all human tissues examined except peripheral blood leukocytes [1].
• We developed a new bioreactor design (ALEX), associated with a new extracellular autologous hepatocyte biomatrix (Porcine Autologous Biomatrix - PBM) support [15].

Associations of ARMCX1 with chemical compounds

• Aldosterone levels significantly increased after both i.v. ALEX doses, but not after HEX [16].
• The ACTH and cortisol responses to the highest ALEX dose were significantly higher than those after HEX [16].
• SOM-Al model, approved by using Alex instead of organically bound aluminium (i.e., Alp and Alcu), could depict the changes in Al activities most successfully [17].
• The educational efforts of American dermatologists such as Dr. Alex Fisher have helped lead to the deletion of ethylenediamine from Mycolog cream [18].
• Dr Alex Gatherer, Oxfordshire AHA(T) area medical officer, with the help of Katrina Bishop and Alexandre Kalache, a clinical lecturer in community medicine at Oxford University, tried to answer these and other questions [19].

Other interactions of ARMCX1

• The genes encoding ALEX1, ALEX2 and ALEX3 co-localize to the same region in Xq21.33-q22 [1].

Analytical, diagnostic and therapeutic context of ARMCX1

• Here, Alex Chen and colleagues review current progress in the field of vascular NOS gene transfer and the potential use of NOS gene therapy for a number of cardiovascular diseases [20].
• RESULTS: The immediate pain after treatment was more severe for QS Alex than for QS Nd:YAG laser [21].
• Alex Black, a staff nurse on an intensive care unit, was extremely concerned about the lack of adequate staffing levels on the unit [22].

References