The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

KRT76  -  keratin 76, type II

Homo sapiens

Synonyms: CK-2P, Cytokeratin-2P, HUMCYT2A, K2P, K76, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of KRT76

  • Sustained reflow in dogs with coronary thrombosis with K2P, a novel mutant of tissue-plasminogen activator [1].
  • In this study we compared the thrombolytic effect of K2P and rt-PA in dogs with electrically induced coronary artery thrombosis [1].
  • MATERIALS AND METHODS: Preoperative bone marrow aspirates of 82 patients with localized (N0) and lymphatically spread (N1) prostate cancer were examined using the monoclonal antibody cytokeratin 2 and the pan-cytokeratin antibody A 45-B/B3, called A 45 [2].
  • It begins with an overview of the role of background K+ channels in neuronal excitability and nerve conduction and is followed by a description of the K2P channel family including experimental evidence for the contribution of K2P channels to the mechanism of action and toxicity of local anesthetics [3].

High impact information on KRT76

  • The number of neurofilament-positive cells increased with time after initial exposure to retinoic acid, and although 95% of these cells contained cytokeratin initially, less than 5% of the neurofilament-positive cells retained cytokeratin 2 weeks later [4].
  • Because this cross-link contains two lysine residues and a dihydropyridinium ring, we assigned it the trivial name of K2P [5].
  • We sought to determine the segment-specific expression of transcripts for the 14 known K2P channel genes in human nephron to identify potential correlates of native leak channels [6].
  • K2P channels have properties of background or leak K+ channels, and therefore play a crucial role in setting the resting membrane potential and regulating cell excitability [7].
  • Some K2P channels are targets of agonists that bind receptors coupled to different types of G proteins, and are probably involved in a variety of neurotransmitter and peptide hormone-mediated signal transduction processes [7].

Biological context of KRT76

  • Purification of the kringle 2 domain derived from elastase cleavage of K2P at the Arg275-Ile276 bond revealed that inhibition was mediated by this domain [8].
  • In addition, K2P inhibited angiogenesis in vivo and increased endothelial cell apoptosis [8].
  • CONCLUSIONS: Wound healing and angiogenesis are severely compromised by K2P [8].
  • Glycation breaker discovery would use high-throughput screening and rational drug design to find molecules that are able to break glucosepane crosslinks and K2P crosslinks of extracellular proteins [9].

Anatomical context of KRT76

  • Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different [10].
  • CONCLUSION: Human cytotrophoblast cells from term placenta are a site of expression for various K2P genes, two of which, namely, TASK1 and TREK1, are transcribed into protein [11].
  • TRESK (TWIK-related spinal cord K+ channel) is the most recently characterized member of the tandem-pore domain potassium channel (K2P) family [12].
  • K2P channels are widely expressed in the central nervous system and are involved in the control of the resting membrane potential and the firing pattern of excitable cells [3].
  • We investigated effects of H2O2 on various K2P channels expressed in CHO cells [13].

Associations of KRT76 with chemical compounds

  • Enzymatically active K2P was liberated from the fusion protein by cleavage at a unique Asn-Gly dipeptide sequence using hydroxylamine [14].
  • Human TRESK is potently activated by halothane, isoflurane, sevoflurane, and desflurane, making it the most sensitive volatile anesthetic-activated K2P channel yet described [12].
  • Experiments with kringle-2 ligands and a deletion mutant of t-PA (K2P) suggests that glutamic or aspartic acid residues in K2 of t-PA are involved in stimulation of activity, lysine binding and fibrin binding [15].
  • The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration [16].

Analytical, diagnostic and therapeutic context of KRT76

  • In situ hybridization and real-time PCR studies in wild-type and TASK-1 knock-outs (KOs) demonstrated that the expression of other K2P channels was unaltered in CGNs [17].


  1. Sustained reflow in dogs with coronary thrombosis with K2P, a novel mutant of tissue-plasminogen activator. Nicolini, F.A., Nichols, W.W., Mehta, J.L., Saldeen, T.G., Schofield, R., Ross, M., Player, D.W., Pohl, G.B., Mattsson, C. J. Am. Coll. Cardiol. (1992) [Pubmed]
  2. Disseminated cytokeratin positive tumor cells in the bone marrow of patients with prostate cancer: detection and prognostic value. Weckermann, D., Müller, P., Wawroschek, F., Harzmann, R., Riethmüller, G., Schlimok, G. J. Urol. (2001) [Pubmed]
  3. Two-pore domain potassium channels: new sites of local anesthetic action and toxicity. Kindler, C.H., Yost, C.S. Regional anesthesia and pain medicine. (2005) [Pubmed]
  4. Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins. Lee, V.M., Andrews, P.W. J. Neurosci. (1986) [Pubmed]
  5. Structure elucidation of a novel yellow chromophore from human lens protein. Cheng, R., Feng, Q., Argirov, O.K., Ortwerth, B.J. J. Biol. Chem. (2004) [Pubmed]
  6. Segment-specific expression of 2P domain potassium channel genes in human nephron. Levy, D.I., Velazquez, H., Goldstein, S.A., Bockenhauer, D. Kidney Int. (2004) [Pubmed]
  7. Physiology and pharmacology of two-pore domain potassium channels. Kim, D. Curr. Pharm. Des. (2005) [Pubmed]
  8. Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2. Carroll, V.A., Nikitenko, L.L., Bicknell, R., Harris, A.L. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  9. Extracellular glycation crosslinks: prospects for removal. Furber, J.D. Rejuvenation research. (2006) [Pubmed]
  10. Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different. Collin, C., Ouhayoun, J.P., Grund, C., Franke, W.W. Differentiation (1992) [Pubmed]
  11. Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells. Bai, X., Greenwood, S.L., Glazier, J.D., Baker, P.N., Sibley, C.P., Taggart, M.J., Fyfe, G.K. J. Soc. Gynecol. Investig. (2005) [Pubmed]
  12. Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK. Keshavaprasad, B., Liu, C., Au, J.D., Kindler, C.H., Cotten, J.F., Yost, C.S. Anesth. Analg. (2005) [Pubmed]
  13. Hydrogen peroxide selectively increases TREK-2 currents via myosin light chain kinases. Kim, Y., Lee, S.H., Ho, W.K. Front. Biosci. (2007) [Pubmed]
  14. Synthesis and secretion of a fibrinolytically active tissue-type plasminogen activator variant in Escherichia coli. Waldenström, M., Holmgren, E., Attersand, A., Kalderén, C., Löwenadler, B., Rådén, B., Hansson, L., Pohl, G. Gene (1991) [Pubmed]
  15. Involvement of aspartic and glutamic residues in kringle-2 of tissue-type plasminogen activator in lysine binding, fibrin binding and stimulation of activity as revealed by chemical modification and oligonucleotide-directed mutagenesis. Weening-Verhoeff, E.J., Quax, P.H., van Leeuwen, R.T., Rehberg, E.F., Marotti, K.R., Verheijen, J.H. Protein Eng. (1990) [Pubmed]
  16. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Cotten, J.F., Keshavaprasad, B., Laster, M.J., Eger, E.I., Yost, C.S. Anesth. Analg. (2006) [Pubmed]
  17. Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons. Aller, M.I., Veale, E.L., Linden, A.M., Sandu, C., Schwaninger, M., Evans, L.J., Korpi, E.R., Mathie, A., Wisden, W., Brickley, S.G. J. Neurosci. (2005) [Pubmed]
WikiGenes - Universities