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Gene Review

VIT  -  vitrin

Homo sapiens

Synonyms: UNQ647/PRO1277, Vitrin
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Disease relevance of VIT

  • BACKGROUND: specific immunotherapy for Hymenoptera Venom (VIT) is considered a life-saving treatment in insect sting allergy [1].
  • Background. To investigate the therapeutic consequences of restricting the CSF dynamic evaluation to a lumbar infusion test (LIT), as opposed to our formerly applied intraventricular assessment (VIT), in patients with communicating hydrocephalus (CH).Method [2].
  • A pre- and postnatal study was carried out to investigate the effect of high dose (500 mg/kg) of the natural antioxidant vitamin E (VIT E) on biochemical variables in the model of chronic intrauterine hypoxia [3].

High impact information on VIT


Biological context of VIT

  • Rats were orally treated with PHT (150 mg/kg) from day 7 to 18 of gestation and VIT E prior to PHT orally on the same days [3].

Anatomical context of VIT

  • VIT 45 is not dialyzed by HE or HF dialysis membranes irrespective of UFR [7].
  • The proportion of spermatozoa with primary morphological defects appeared to be greater in -VIT bulls compared to +VIT bulls by 26 and 24 wk in Year 1 and 2, respectively [8].
  • We compared simulations with data including the dynamic changes in plasma and interstitial fluid volumes VPL and VIT respectively, plasma and interstitial colloid osmotic pressures PiPL and PiIT respectively, haematocrit (Hct), plasma solute concentrations and transcapillary flow rates [9].
  • VIT components displaced into the pulp tissue triggered a persistent inflammatory reaction which appeared to be associated with a lack of dentin bridge formation [10].

Associations of VIT with chemical compounds

  • Bulls were fed a high-concentrate diet with (+VIT) or without (-VIT) supplemental Vitamin A until the apparent onset of hypovitaminosis A (28 and 32 wk in Year 1 and 2, respectively) [8].
  • The miscibility pressures obtained from the new VIT technique were 3-5% higher than those from visual observations and agreed well with the slim-tube results as well as with the correlations at enrichment levels greater than 30 mol% C2+ in the injected gas stream [11].
  • No evidence was found of oxidative damage in the serum during hemodialysis, serum concentrations of MDA and VIT E remaining constant before and after dialysis [12].
  • Determination of VIT 45 (IND#63,243 - American Regent) removal by closed loop in vitro hemodialysis system [7].
  • The aim of this investigation was to evaluate fluoride release and uptake from 4 glass ionomer cements (GICs)--Vitremer (VIT), Fuji II LC (FII LC), Fuji IX (FIX), Chelon Fill (CHE)--and 2 composite resins (CRs)--Heliomolar (H) and Zeta-100 (Z-100) [13].

Analytical, diagnostic and therapeutic context of VIT

  • Progress and further questions continue with a search for a definitive diagnostic test that more accurately predicts which patients are at risk for future reactions, and defines which patients can stop VIT and which ones need to continue treatment [14].
  • The extent of VIT 45, a novel intravenous iron formulation, removal by high-flux (HF) or high-efficiency (HE) dialysis membranes at various ultrafiltration rates (UFR) is unknown [7].
  • These results suggested that VIT is not an appropriate dental material to be used in direct pulp capping for mechanically exposed human pulps [10].
  • METHODS: this retrospective study was designed to evaluate both efficacy and safety of depot VIT for Vespula [1].


  1. The safety and efficacy of immunotherapy with aluminum hydroxide-adsorbed venom extract of Vespula spp. An open, retrospective study. Poli, F., Longo, G., Parmiani, S. Allergologia et immunopathologia. (2001) [Pubmed]
  2. Intraventricular or lumbar infusion test in adult communicating hydrocephalus? Practical consequences and clinical outcome of shunt operation. Bech-Azeddine, R., Gjerris, F., Waldemar, G., Czosnyka, M., Juhler, M. Acta neurochirurgica. (2005) [Pubmed]
  3. Phenytoin induced oxidative stress in pre- and postnatal rat development - effect of vitamin E on selective biochemical variables. Navarová, J., Ujházy, E., Dubovický, M., Mach, M. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia. (2005) [Pubmed]
  4. Supplementation with vitamins C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction. Herbaczyńska-Cedro, K., K+osiewicz-Wasek, B., Cedro, K., Wasek, W., Panczenko-Kresowska, B., Wartanowicz, M. Eur. Heart J. (1995) [Pubmed]
  5. Characterization of vitiligo antigens. Cui, J., Arita, Y., Bystryn, J.C. Pigment Cell Res. (1995) [Pubmed]
  6. Shared antigenic determinants between human hemopoietic cells and nervous tissues and tumors. Budka, H., Majdic, O. Acta Neuropathol. (1985) [Pubmed]
  7. Determination of VIT 45 (IND#63,243 - American Regent) removal by closed loop in vitro hemodialysis system. Manley, H.J., McClaran, M.L. The International journal of artificial organs (2006) [Pubmed]
  8. Seminal quality and sperm production in beef bulls with chronic dietary vitamin a deficiency and subsequent re-alimentation. Rode, L.M., Coulter, G.H., Kastelic, J.P., Bailey, D.R. Theriogenology (1995) [Pubmed]
  9. A model of fluid and solute exchange in the human: validation and implications. Bert, J.L., Gyenge, C.C., Bowen, B.D., Reed, R.K., Lund, T. Acta Physiol. Scand. (2000) [Pubmed]
  10. Biocompatibility of a resin-modified glass-ionomer cement applied as pulp capping in human teeth. do Nascimento, A.B., Fontana, U.F., Teixeira, H.M., Costa, C.A. American journal of dentistry. (2000) [Pubmed]
  11. Determination of gas-oil miscibility conditions by interfacial tension measurements. Rao, D.N., Lee, J.I. Journal of colloid and interface science. (2003) [Pubmed]
  12. Lack of oxidative damage in serum polyunsaturated fatty acids before and after dialysis in chronic uremic patients. Taccone-Gallucci, M., Lubrano, R., Belli, A., Citti, G., Morosetti, M., Meloni, C., Elli, M., Mazzarella, V., Tozzo, C., Meschini, L. The International journal of artificial organs. (1989) [Pubmed]
  13. Fluoride release and uptake from glass ionomer cements and composite resins. Weidlich, P., Miranda, L.A., Maltz, M., Samuel, S.M. Brazilian dental journal. (2000) [Pubmed]
  14. Insect sting allergy. Graft, D.F. Med. Clin. North Am. (2006) [Pubmed]
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