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Gene Review

KCNK10  -  potassium channel, two pore domain...

Homo sapiens

Synonyms: K2p10.1, Outward rectifying potassium channel protein TREK-2, PPP1R97, Potassium channel subfamily K member 10, TREK-2, ...
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High impact information on KCNK10


Biological context of KCNK10

  • Our results suggest that alternative splicing of TREK-2 contributes to the diversity of two-pore-domain K+ channels [3].
  • Two novel alternatively spliced isoforms of the human two-pore-domain potassium channel TREK-2 were isolated from cDNA libraries of human kidney and fetal brain [3].
  • These results suggest that the agonist-induced inhibition of TREK-2 via M(3) receptor occurs primarily via PKC-mediated phosphorylation [4].
  • Thus, the C-terminus endows TREK-2 with unique channel kinetics and the ability to be gated by free fatty acids and low pHi, and with increased mechanosensitivity [5].

Anatomical context of KCNK10


Associations of KCNK10 with chemical compounds


Other interactions of KCNK10


  1. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. Sano, Y., Inamura, K., Miyake, A., Mochizuki, S., Kitada, C., Yokoi, H., Nozawa, K., Okada, H., Matsushime, H., Furuichi, K. J. Biol. Chem. (2003) [Pubmed]
  2. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. Lesage, F., Terrenoire, C., Romey, G., Lazdunski, M. J. Biol. Chem. (2000) [Pubmed]
  3. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. Gu, W., Schlichthörl, G., Hirsch, J.R., Engels, H., Karschin, C., Karschin, A., Derst, C., Steinlein, O.K., Daut, J. J. Physiol. (Lond.) (2002) [Pubmed]
  4. Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor. Kang, D., Han, J., Kim, D. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  5. Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi. Kim, Y., Gnatenco, C., Bang, H., Kim, D. Pflugers Arch. (2001) [Pubmed]
  6. TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family. Bang, H., Kim, Y., Kim, D. J. Biol. Chem. (2000) [Pubmed]
  7. Zinc activates TREK-2 potassium channel activity. Kim, J.S., Park, J.Y., Kang, H.W., Lee, E.J., Bang, H., Lee, J.H. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  8. Expression of stretch-activated potassium channels in human myometrium. Tichenor, J.N., Hansen, E.T., Buxton, I.L. Proc. West. Pharmacol. Soc. (2005) [Pubmed]
  9. Hydrogen peroxide selectively increases TREK-2 currents via myosin light chain kinases. Kim, Y., Lee, S.H., Ho, W.K. Front. Biosci. (2007) [Pubmed]
  10. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Medhurst, A.D., Rennie, G., Chapman, C.G., Meadows, H., Duckworth, M.D., Kelsell, R.E., Gloger, I.I., Pangalos, M.N. Brain Res. Mol. Brain Res. (2001) [Pubmed]
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