Gene Review:
PPP1R3A - protein phosphatase 1, regulatory subunit 3A
Homo sapiens
Synonyms:
GM, PP1G, PPP1R3, Protein phosphatase 1 glycogen-associated regulatory subunit, Protein phosphatase 1 regulatory subunit 3A, ...
- Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. Delibegovic, M., Armstrong, C.G., Dobbie, L., Watt, P.W., Smith, A.J., Cohen, P.T. Diabetes (2003)
- PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis. Hayashida, Y., Goi, T., Hirono, Y., Katayama, K., Urano, T., Yamaguchi, A. Oncol. Rep. (2005)
- The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus. Wang, G., Qian, R., Li, Q., Niu, T., Chen, C., Xu, X. Chin. Med. J. (2001)
- Alterations of the PPP1R3 gene in human cancer. Kohno, T., Takakura, S., Yamada, T., Okamoto, A., Tanaka, T., Yokota, J. Cancer Res. (1999)
- A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hansen, L., Hansen, T., Vestergaard, H., Bjørbaek, C., Echwald, S.M., Clausen, J.O., Chen, Y.H., Chen, M.X., Cohen, P.T., Pedersen, O. Hum. Mol. Genet. (1995)
- Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM. Chen, Y.H., Hansen, L., Chen, M.X., Bjørbaek, C., Vestergaard, H., Hansen, T., Cohen, P.T., Pedersen, O. Diabetes (1994)
- Peroxisome proliferator-activated receptor-gamma and insulin action: insights from human genetics. Chatterjee, V.K. Horm. Res. (2003)
- Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. Alcoser, S.Y., Hara, M., Bell, G.I., Ehrmann, D.A. J. Clin. Endocrinol. Metab. (2004)
- Somatic mutations and genetic polymorphisms of the PPP1R3 gene in patients with several types of cancers. Takakura, S., Kohno, T., Shimizu, K., Ohwada, S., Okamoto, A., Yokota, J. Oncogene (2000)
- Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes. Rasmussen, S.K., Hansen, L., Frevert, E.U., Cohen, P.T., Kahn, B.B., Pedersen, O. Diabetologia (2000)
- Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity. Hansen, L., Reneland, R., Berglund, L., Rasmussen, S.K., Hansen, T., Lithell, H., Pedersen, O. Diabetes (2000)
- Asp905Tyr polymorphism of protein phosphatase 1 G subunit gene in hypertension. Shen, G.Q., Ikegami, H., Fujisawa, T., Hamada, Y., Kamide, K., Rakugi, H., Higaki, J., Murakami, H., Shimamoto, K., Ogihara, T. Hypertension (1997)
- Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. Liolitsa, D., Powell, J., Lovestone, S. J. Neurol. Neurosurg. Psychiatr. (2002)
- Identification of skeletal muscle autoantigens by expression library screening using sera from autoimmune rippling muscle disease (ARMD) patients. Watkins, T.C., Zelinka, L.M., Kesic, M., Ansevin, C.F., Walker, G.R. J. Cell. Biochem. (2006)
- Alterations of the PPP1R3 gene in hematological malignancies. Inoue, K., Kohno, T., Takakura, S., Morishita, K., Takita, J., Hayashi, Y., Mizoguchi, H., Yokota, J. Int. J. Oncol. (2000)