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Gene Review

SBNO1  -  strawberry notch homolog 1 (Drosophila)

Homo sapiens

Synonyms: FLJ10701, FLJ10833, MOP-3, MOP3, Monocyte protein 3, ...
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Disease relevance of SBNO1

  • CONCLUSIONS: Cervical or vaginal swab, vaginal Sno Strip, and CVL collection led to reproducible measurement of genital HIV-1 RNA, despite storage for several months and international transport [1].
  • To assess the reproducibility of measurements of cervical and vaginal human immunodeficiency virus (HIV) viral load, 92 duplicate cervical and 88 duplicate vaginal samples were collected from 13 HIV-infected women using Sno Strip filter-paper wicks [2].
  • Characterization of Sno expression in malignant melanoma [3].

High impact information on SBNO1


Biological context of SBNO1


Anatomical context of SBNO1


Associations of SBNO1 with chemical compounds

  • Cefuroxime was adequately preserved in a vehicle of Sno Tears, which contains benzalkonium chloride as the antimicrobial preservative [9].
  • METHOD: Ceftazidime was formulated at a concentration of 5% w/v as an eye drop, using Sno Tears, an artificial tear solution containing polyvinyl alcohol, as a vehicle [10].

Analytical, diagnostic and therapeutic context of SBNO1

  • Using the promoterless dicistronic vector, we also found promoter activities in the long 5'-UTRs of human Sno and mouse Bad mRNAs although monocistronic transcripts were not detectable on Northern blot analyses [11].
  • Applying repeated-measures models that used menses as the reference level, the variation in viral RNA levels was compared in endocervical canal fluid and cells (collected by Sno-strips and cytobrush, respectively) and ectocervicovaginal lavage (CVL) fluid [12].
  • Adoptive transfer of MOP3(-/-) bone marrow cells (BMC) to lethally irradiated BALB/c Rag2(-/-) recipients, normal T and B cell development was observed, whereas Adoptive transfer of BALB/c BMC to lethally irradiated MOP3(-/-) recipients, B-cell development was significantly impaired [8].


  1. Comparison of techniques for HIV-1 RNA detection and quantitation in cervicovaginal secretions. John, G.C., Sheppard, H., Mbori-Ngacha, D., Nduati, R., Maron, D., Reiner, M., Kreiss, J. J. Acquir. Immune Defic. Syndr. (2001) [Pubmed]
  2. Use of Sno Strip filter-paper wicks for collection of genital-tract samples allows reproducible determination of human immunodeficiency virus type 1 (HIV-1) RNA viral load with a commercial HIV-1 viral load assay. Sherlock, C.H., Lott, P.M., Money, D.M., Merrick, L., Arikan, Y., Remple, V.P., Craib, K., Burdge, D.R. J. Clin. Microbiol. (2006) [Pubmed]
  3. Characterization of Sno expression in malignant melanoma. Poser, I., Rothhammer, T., Dooley, S., Weiskirchen, R., Bosserhoff, A.K. Int. J. Oncol. (2005) [Pubmed]
  4. Eukaryotic rRNA methylation: the calm before the Sno storm. Maden, B.E. Trends Biochem. Sci. (1998) [Pubmed]
  5. Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription. Leong, G.M., Subramaniam, N., Figueroa, J., Flanagan, J.L., Hayman, M.J., Eisman, J.A., Kouzmenko, A.P. J. Biol. Chem. (2001) [Pubmed]
  6. SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno. Pearson-White, S. Nucleic Acids Res. (1993) [Pubmed]
  7. Differences in HIV-1 pol sequences from female genital tract and blood during antiretroviral therapy. De Pasquale, M.P., Leigh Brown, A.J., Uvin, S.C., Allega-Ingersoll, J., Caliendo, A.M., Sutton, L., Donahue, S., D'Aquila, R.T. J. Acquir. Immune Defic. Syndr. (2003) [Pubmed]
  8. MOP3, a component of the molecular clock, regulates the development of B cells. Sun, Y., Yang, Z., Niu, Z., Peng, J., Li, Q., Xiong, W., Langnas, A.N., Ma, M.Y., Zhao, Y. Immunology (2006) [Pubmed]
  9. Preservative efficacy in cefuroxime and ceftazidime eye drop formulations. Barnes, A.R., Nash, S. Journal of clinical pharmacy and therapeutics. (1994) [Pubmed]
  10. Stability of ceftazidime in a viscous eye drop formulation. Barnes, A.R., Nash, S. Journal of clinical pharmacy and therapeutics. (1999) [Pubmed]
  11. Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story. Han, B., Zhang, J.T. Mol. Cell. Biol. (2002) [Pubmed]
  12. Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team. Reichelderfer, P.S., Coombs, R.W., Wright, D.J., Cohn, J., Burns, D.N., Cu-Uvin, S., Baron, P.A., Coheng, M.H., Landay, A.L., Beckner, S.K., Lewis, S.R., Kovacs, A.A. AIDS (2000) [Pubmed]
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