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Gene Review

ADORA2A  -  adenosine A2a receptor

Homo sapiens

Synonyms: A2aR, ADORA2, Adenosine receptor A2a, RDC8
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Disease relevance of ADORA2A


Psychiatry related information on ADORA2A


High impact information on ADORA2A


Chemical compound and disease context of ADORA2A


Biological context of ADORA2A


Anatomical context of ADORA2A


Associations of ADORA2A with chemical compounds


Physical interactions of ADORA2A


Co-localisations of ADORA2A


Regulatory relationships of ADORA2A


Other interactions of ADORA2A


Analytical, diagnostic and therapeutic context of ADORA2A


  1. Cerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist. Von Lubitz, D.K., Lin, R.C., Jacobson, K.A. Eur. J. Pharmacol. (1995) [Pubmed]
  2. Neuroprotective role of adenosine in the CNS. Wardas, J. Polish journal of pharmacology. (2002) [Pubmed]
  3. Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys. Kanda, T., Jackson, M.J., Smith, L.A., Pearce, R.K., Nakamura, J., Kase, H., Kuwana, Y., Jenner, P. Ann. Neurol. (1998) [Pubmed]
  4. Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage. Mayne, M., Fotheringham, J., Yan, H.J., Power, C., Del Bigio, M.R., Peeling, J., Geiger, J.D. Ann. Neurol. (2001) [Pubmed]
  5. Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder. Hamilton, S.P., Slager, S.L., De Leon, A.B., Heiman, G.A., Klein, D.F., Hodge, S.E., Weissman, M.M., Fyer, A.J., Knowles, J.A. Neuropsychopharmacology (2004) [Pubmed]
  6. Adenosine A2A receptor dysfunction correlates with age at onset anticipation in blood platelets of subjects with Huntington's disease. Maglione, V., Giallonardo, P., Cannella, M., Martino, T., Frati, L., Squitieri, F. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
  7. Adenosine A2A receptors modify motor function in MPTP-treated common marmosets. Kanda, T., Tashiro, T., Kuwana, Y., Jenner, P. Neuroreport (1998) [Pubmed]
  8. Association study of adenosine A2a receptor (1976C>T) genetic polymorphism and mood disorders and age of onset. Tsai, S.J., Hong, C.J., Hou, S.J., Yen, F.C. Psychiatr. Genet. (2006) [Pubmed]
  9. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Lappas, C.M., Day, Y.J., Marshall, M.A., Engelhard, V.H., Linden, J. J. Exp. Med. (2006) [Pubmed]
  10. Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease. Richardson, P.J., Kase, H., Jenner, P.G. Trends Pharmacol. Sci. (1997) [Pubmed]
  11. Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. Chan, E.S., Fernandez, P., Merchant, A.A., Montesinos, M.C., Trzaska, S., Desai, A., Tung, C.F., Khoa, D.N., Pillinger, M.H., Reiss, A.B., Tomic-Canic, M., Chen, J.F., Schwarzschild, M.A., Cronstein, B.N. Arthritis Rheum. (2006) [Pubmed]
  12. Association study of A2a adenosine receptor genetic polymorphism in panic disorder. Lam, P., Hong, C.J., Tsai, S.J. Neurosci. Lett. (2005) [Pubmed]
  13. Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor-mediated responses. Ralph, J.A., McEvoy, A.N., Kane, D., Bresnihan, B., FitzGerald, O., Murphy, E.P. J. Immunol. (2005) [Pubmed]
  14. Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson's disease and schizophrenia. Hong, C.J., Liu, H.C., Liu, T.Y., Liao, D.L., Tsai, S.J. Journal of neural transmission (Vienna, Austria : 1996) (2005) [Pubmed]
  15. A double-blind crossover, placebo-controlled study of the adenosine A2A antagonist theophylline in Parkinson's disease. Kulisevsky, J., Barbanoj, M., Gironell, A., Antonijoan, R., Casas, M., Pascual-Sedano, B. Clinical neuropharmacology. (2002) [Pubmed]
  16. KW-6002 (Kyowa Hakko Kogyo). Knutsen, L.J., Weiss, S.M. Current opinion in investigational drugs (London, England : 2000) (2001) [Pubmed]
  17. Characterization and expression of the human A2a adenosine receptor gene. Peterfreund, R.A., MacCollin, M., Gusella, J., Fink, J.S. J. Neurochem. (1996) [Pubmed]
  18. Molecular characterization of a human brain adenosine A2 receptor. Furlong, T.J., Pierce, K.D., Selbie, L.A., Shine, J. Brain Res. Mol. Brain Res. (1992) [Pubmed]
  19. Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism. Yasui, K., Agematsu, K., Shinozaki, K., Hokibara, S., Nagumo, H., Nakazawa, T., Komiyama, A. J. Leukoc. Biol. (2000) [Pubmed]
  20. Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A. Le, F., Townsend-Nicholson, A., Baker, E., Sutherland, G.R., Schofield, P.R. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  21. Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. Torvinen, M., Marcellino, D., Canals, M., Agnati, L.F., Lluis, C., Franco, R., Fuxe, K. Mol. Pharmacol. (2005) [Pubmed]
  22. Effect of adenosine receptor agonists on release of the nucleoside analogue [3H]formycin B from cultured smooth muscle DDT1 MF-2 cells. Borgland, S.L., Parkinson, F.E. Eur. J. Pharmacol. (1998) [Pubmed]
  23. Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells. Rego, A.C., Agostinho, P., Melo, J., Cunha, R.A., Oliveira, C.R. Exp. Eye Res. (2000) [Pubmed]
  24. Adenosine A2a receptors increase arterial endothelial cell nitric oxide. Li, J., Fenton, R.A., Wheeler, H.B., Powell, C.C., Peyton, B.D., Cutler, B.S., Dobson, J.G. J. Surg. Res. (1998) [Pubmed]
  25. Biochemical identification of the dopamine D2 receptor domains interacting with the adenosine A2A receptor. Torvinen, M., Kozell, L.B., Neve, K.A., Agnati, L.F., Fuxe, K. J. Mol. Neurosci. (2004) [Pubmed]
  26. Characterization of A2A adenosine receptors in human lymphocyte membranes by [3H]-SCH 58261 binding. Varani, K., Gessi, S., Dalpiaz, A., Ongini, E., Borea, P.A. Br. J. Pharmacol. (1997) [Pubmed]
  27. Cellular distribution of adenosine A2A receptor mRNA in the primate striatum. Svenningsson, P., Le Moine, C., Aubert, I., Burbaud, P., Fredholm, B.B., Bloch, B. J. Comp. Neurol. (1998) [Pubmed]
  28. Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Desai, A., Victor-Vega, C., Gadangi, S., Montesinos, M.C., Chu, C.C., Cronstein, B.N. Mol. Pharmacol. (2005) [Pubmed]
  29. Adenosine A2a receptor/dopamine D2 receptor hetero-oligomerization: a hypothesis that may explain behavioral sensitization to psychostimulants and schizophrenia. Tsai, S.J. Med. Hypotheses (2005) [Pubmed]
  30. RDC8 codes for an adenosine A2 receptor with physiological constitutive activity. Maenhaut, C., Van Sande, J., Libert, F., Abramowicz, M., Parmentier, M., Vanderhaegen, J.J., Dumont, J.E., Vassart, G., Schiffmann, S. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  31. Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement. Grenier, S., Flamand, N., Pelletier, J., Naccache, P.H., Borgeat, P., Bourgoin, S.G. J. Leukoc. Biol. (2003) [Pubmed]
  32. Site-directed mutagenesis of the human adenosine A2A receptor. Critical involvement of Glu13 in agonist recognition. IJzerman, A.P., Von Frijtag Drabbe Künzel, J.K., Kim, J., Jiang, Q., Jacobson, K.A. Eur. J. Pharmacol. (1996) [Pubmed]
  33. Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor. Ravyn, V., Bostwick, J.R. J. Recept. Signal Transduct. Res. (2006) [Pubmed]
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