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Gene Review

PROL1  -  proline rich, lacrimal 1

Homo sapiens

Synonyms: BPLP, Basic proline-rich lacrimal protein, PRL1, Proline-rich protein 1, opiorphin
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Disease relevance of PROL1

  • We stably transfected human A549 lung cancer cells with several short hairpin RNAs for PRL-1 and found decreased invasive activity in the resulting clones compared with control cells [1].
  • These results support the hypothesis that PRL-1 plays an important role in maintaining the malignant phenotype by exploiting Src activation processes, and that PRL-1 could be a promising therapeutic target for cancer metastasis and cell growth [1].
  • We measured serum calcium, phosphate, PTH, 25-hydroxyvitamin D, 1,25-(OH)2D, 24,25-(OH)2D, alkaline phosphatase (sAP), and the urinary hydroxyproline/creatinine ratio (UOH prol/creat) in 19 patients with Paget's disease of bone and 16 age- and sex-matched controls [2].

High impact information on PROL1


Chemical compound and disease context of PROL1


Biological context of PROL1

  • Prol BE, ramp BE, and TMW also differed significantly with respect to ventilation (22 +/- 7 l.min-1; 26 +/- 6 l/min-1; 29 +/- 7 l.min-1; P < 0.01) and heart rate (100 +/- 15 beats.min-1; 103 +/- 18 beats.min-1; 110 +/- 16 beats.min-1; P < 0.017) [4].

Anatomical context of PROL1


Associations of PROL1 with chemical compounds


Analytical, diagnostic and therapeutic context of PROL1

  • As expected, sAP, UOH prol/creat, and sBGP levels were significantly elevated, and there was a tendency to a decrease in serum levels of 24,25-(OH)2D in Pagetic patients with respect to the control group [2].
  • On three consecutive days patients performed cycle ergometry supine, with prolonged steps (prol BE) and right heart catheterization, ramplike cycle ergometry sitting (ramp BE), and ramplike treadmill walking (TMW) [4].
  • From the immunoassays tested, PROL-CTK was the system which was less correlated with the Nb2 bioassay in group 2 (r=0.252; NS) [6].


  1. PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. Achiwa, H., Lazo, J.S. Cancer Res. (2007) [Pubmed]
  2. Correlation between serum osteocalcin and 24,25-dihydroxyvitamin D levels in Paget's disease of bone. Castro-Errecaborde, N., de la Piedra, C., Rapado, A., Alvarez-Arroyo, M.V., Torres, R., Traba, M.L. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  3. Estrogen synthesis in normal and malignant human endometrium. Tseng, L., Mazella, J., Mann, W.J., Chumas, J. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  4. Influence of different exercise protocols on functional capacity and symptoms in patients with chronic heart failure. Meyer, K., Stengele, E., Westbrook, S., Beneke, R., Schwaibold, M., Görnandt, L., Lehmann, M., Roskamm, H. Medicine and science in sports and exercise. (1996) [Pubmed]
  5. cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein. Dickinson, D.P., Thiesse, M. Curr. Eye Res. (1996) [Pubmed]
  6. Hyperprolactinemia due to big big prolactin is differently detected by commercially available immunoassays. Cavaco, B., Prazeres, S., Santos, M.A., Sobrinho, L.G., Leite, V. J. Endocrinol. Invest. (1999) [Pubmed]
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