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Gene Review

NFKBIZ  -  nuclear factor of kappa light polypeptide...

Homo sapiens

Synonyms: FLJ34463, I-kappa-B-zeta, IKBZ, IL-1 inducible nuclear ankyrin-repeat protein, INAP, ...
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Disease relevance of NFKBIZ

  • Each week between January and April 1998 a different laboratory represented at the Public Health Laboratory Service HIV Diagnosis Forum sent aliquots of the same anti-HIV positive plasma specimen by First Class Mail to the other 12 laboratories and to itself [1].
  • The INAP recording identifies functional axons within neuromas before other signs of reinnervation have developed [2].
  • Data were collected on 228 consecutive back injuries in Boston's General Mail Facility and 228 non-injured controls drawn randomly from each case's work unit, matching on craft (clerk, mailhandler, maintenance), shift, and general supervisor [3].
  • DESIGN: Mail surveys were completed by 409 adults with self-reported osteoarthritis or rheumatoid arthritis who were recruited through a variety of recruitment strategies such as advertisements placed in arthritis publications, internet sources, and physician referrals [4].
  • METHODS: Mail questionnaire to all Surgical Departments in Sweden about the current use of thromboembolism prophylaxis in patients undergoing laparoscopic cholecystectomy [5].

Psychiatry related information on NFKBIZ

  • DESIGN AND PARTICIPANTS: Mail survey in 2934 daily smokers (1533 women and 1401 men) who volunteered for a smoking cessation trial [6].
  • METHODS: Mail surveys were returned by 442 members of the King County (WA) MS Association. Average pain intensity, pain-related activity interference, depressive symptoms and severity of MS were assessed [7].
  • OBJECTIVE: Mail and Web surveys are two possible alternatives for reducing potential nonresponse bias in telephone-based studies of alcohol consumption [8].
  • DESIGN: Mail survey requesting information on physical activity, basic demographic characteristics, self-rated health, and self-rated physical activity [9].
  • RESULTS: In the Mail group, the perceived importance of barriers to dietary change decreased by 19% at postintervention and 16% at 1-year follow-up; dietary self-efficacy increased by 9% and 3%, respectively [10].

High impact information on NFKBIZ

  • METHODS: Mail survey of 824 Pennsylvania physicians in general surgery, neurosurgery, orthopedic surgery, obstetrics/gynecology, emergency medicine, and radiology eliciting information on practice decisions made in response to rising liability costs [11].
  • METHODS: Mail survey of 1000 Colorado physicians (n = 594) and 1000 national physicians (n = 304), and telephone survey of 500 Colorado households to assess agreement with several proposals and conclusions from the 1999 Institute of Medicine report [12].
  • The Mail and Mail Plus Incentive interventions were estimated to produce increases in Sage screening rates of 0.23% and 0.75%, respectively, beyond the composite Control rate of 0.83% [13].
  • DESIGN: Mail surveys were conducted with healthcare workers (HCWs) and infection control professionals (ICPs) [14].
  • DESIGN: Mail survey in 386 smokers, retest at one month in 94 participants (24%), analysis of saliva cotinine in 98 participants (25%), collection of empty cigarette packs in 214 participants (55%), collection of cigarette butts in 107 participants (28%) [15].

Biological context of NFKBIZ


Anatomical context of NFKBIZ

  • INAP can aid peripheral nerve tumor resection by identification of intact nerve fascicles [2].
  • In clinically complete lesions, recording an INAP across the injury indicates the presence of regenerating axons, and neurolysis of the encasing connective tissue is recommended [2].

Associations of NFKBIZ with chemical compounds

  • INAP (median=4.2 microg/l and 3.3 microg/g creatinine) and TCPY (median=5.3 microg/l and 4.6. microg/g creatinine) were present in over 80% of the samples, while MDA and AM were detected infrequently (6.6% and <1% of samples, respectively) [21].

Analytical, diagnostic and therapeutic context of NFKBIZ

  • After 1 year, both intervention groups had significantly higher Sage mammography rates than the Controls, and the Mail Plus Incentive group had a significantly higher rate than the Mail group [13].
  • BACKGROUND: Mail survey questionnaires are increasingly being used for follow-up evaluations to gauge satisfaction and performance after total joint arthroplasty [22].
  • METHODS: Mail-questionnaire study, which was performed in a county in the south-east of Sweden, as a retrospective cross-sectional survey including 1990 children, 12-24 months old [23].
  • Gnome (GenomeNet Open Mail-service Environment) is a sequence analysis tool that enables an end-user to make use of several Internet- (mainly e-mail) based services with an easy-to-use graphical user interface [24].
  • DESIGN: Mail survey using 2 hypothetical case studies sent to pediatric critical care physicians [25].


  1. Accuracy of plasma HIV RNA quantification: a multicentre study of variability. Skidmore, S.J., Zuckerman, M., Parry, J.V. J. Med. Virol. (2000) [Pubmed]
  2. Use of peripheral nerve action potentials for intraoperative monitoring. Nelson, K.R. Neurologic clinics. (1988) [Pubmed]
  3. A case-control study of risk factors for industrial low back injury: implications for primary and secondary prevention programs. Daltroy, L.H., Larson, M.G., Wright, E.A., Malspeis, S., Fossel, A.H., Ryan, J., Zwerling, C., Liang, M.H. Am. J. Ind. Med. (1991) [Pubmed]
  4. Access to healthcare services among persons with osteoarthritis and rheumatoid arthritis. Hagglund, K.J., Clark, M.J., Hilton, S.A., Hewett, J.E. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. (2005) [Pubmed]
  5. Current use of thromboembolism prophylaxis for laparoscopic cholecystectomy patients in Sweden. Lindberg, F., Bjorck, M., Rasmussen, I., Bergqvist, D. Surgical endoscopy. (2005) [Pubmed]
  6. Gender differences in the psychological determinants of cigarette smoking. Etter, J.F., Prokhorov, A.V., Perneger, T.V. Addiction (2002) [Pubmed]
  7. Chronic pain in a large community sample of persons with multiple sclerosis. Ehde, D.M., Gibbons, L.E., Chwastiak, L., Bombardier, C.H., Sullivan, M.D., Kraft, G.H. Mult. Scler. (2003) [Pubmed]
  8. Effects of survey mode on self-reports of adult alcohol consumption: a comparison of mail, web and telephone approaches. Link, M.W., Mokdad, A.H. J. Stud. Alcohol (2005) [Pubmed]
  9. The physical activity scale for individuals with physical disabilities: development and evaluation. Washburn, R.A., Zhu, W., McAuley, E., Frogley, M., Figoni, S.F. Archives of physical medicine and rehabilitation. (2002) [Pubmed]
  10. Changes in cognitive measures in a randomized controlled trial of a health promotion program for couples targeting diet and physical activity. Burke, V., Giangiulio, N., Gillam, H.F., Beilin, L.J., Houghton, S. American journal of health promotion : AJHP. (2004) [Pubmed]
  11. Effects of a malpractice crisis on specialist supply and patient access to care. Mello, M.M., Studdert, D.M., DesRoches, C.M., Peugh, J., Zapert, K., Brennan, T.A., Sage, W.M. Ann. Surg. (2005) [Pubmed]
  12. Physician and public opinions on quality of health care and the problem of medical errors. Robinson, A.R., Hohmann, K.B., Rifkin, J.I., Topp, D., Gilroy, C.M., Pickard, J.A., Anderson, R.J. Arch. Intern. Med. (2002) [Pubmed]
  13. Effect of direct mail as a population-based strategy to increase mammography use among low-income underinsured women ages 40 to 64 years. Slater, J.S., Henly, G.A., Ha, C.N., Malone, M.E., Nyman, J.A., Diaz, S., McGovern, P.G. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  14. Factors promoting consistent adherence to safe needle precautions among hospital workers. Vaughn, T.E., McCoy, K.D., Beekmann, S.E., Woolson, R.E., Torner, J.C., Doebbeling, B.N. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2004) [Pubmed]
  15. Measurement of self reported active exposure to cigarette smoke. Etter, J.F., Perneger, T.V. Journal of epidemiology and community health. (2001) [Pubmed]
  16. Ambulatory care training during core internal medicine residency training: the Canadian experience. McLeod, P.J., Meagher, T.W. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1993) [Pubmed]
  17. Analytical resources for assessment of clinical genetics services in public health: current status and future prospects. Kirby, R.S. Teratology (2000) [Pubmed]
  18. Defensive medicine among high-risk specialist physicians in a volatile malpractice environment. Studdert, D.M., Mello, M.M., Sage, W.M., DesRoches, C.M., Peugh, J., Zapert, K., Brennan, T.A. JAMA (2005) [Pubmed]
  19. Lifestyle factors related to postpartum weight gain and body image in bottle- and breastfeeding women. Walker, L.O., Freeland-Graves, J. Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG. (1998) [Pubmed]
  20. Perceived long-term prognosis of teeth with orthodontically resorbed roots. Lee, K.S., Straja, S.R., Tuncay, O.C. Orthodontics & craniofacial research. (2003) [Pubmed]
  21. A longitudinal investigation of selected pesticide metabolites in urine. MacIntosh, D.L., Needham, L.L., Hammerstrom, K.A., Ryan, P.B. Journal of exposure analysis and environmental epidemiology. (1999) [Pubmed]
  22. Response bias: effect on outcomes evaluation by mail surveys after total knee arthroplasty. Kim, J., Lonner, J.H., Nelson, C.L., Lotke, P.A. The Journal of bone and joint surgery. American volume. (2004) [Pubmed]
  23. Indoor and outdoor smoking: impact on children's health. Johansson, A., Halling, A., Hermansson, G. European journal of public health. (2003) [Pubmed]
  24. Gnome--an Internet-based sequence analysis tool. Nakai, K., Tokimori, T., Ogiwara, A., Uchiyama, I., Niiyama, T. Comput. Appl. Biosci. (1994) [Pubmed]
  25. The current practice patterns of mechanical ventilation for respiratory failure in pediatric patients. Harel, Y., Niranjan, V., Evans, B.J. Heart & lung : the journal of critical care. (1998) [Pubmed]
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