Disease relevance of Root Resorption

• The purpose of this study was to examine the effects of the topical administration of a bisphosphonate, risedronate, which is known to be a potent blocker of bone resorption, on root resorption during tooth movement and on the repair of the resorbed root surface after tooth movement in rats [1].
• Moreover, no instances of epithelial down growth, ankylosis, or root resorption were observed in the bFGF-applied sites examined [2].
• Nabumetone was found to be useful in reducing pulpitis, external root resorption, and pain caused by intrusive orthodontic movement, without altering tooth movement in response to the application of orthodontic force [3].
• The patients with generalized juvenile periodontitis showed considerable deposits of dental calculus and wide areas of root resorption [4].
• DESIGN: Seventy-five individuals with UCLP (52 males, 23 females), between ages 8 and 20 years, participated in a retrospective study during their final follow-up visit with regard to dental abnormalities, such as hypodontia, external root resorption, crown and root malformation, and supernumerary teeth [5].

Psychiatry related information on Root Resorption

• In addition, this may lead to the generation of anti-inflammatory mediators that support defense mechanisms against root resorption, which depend on the type of immune response that is induced regarding CD40-CD40L expression [6].

High impact information on Root Resorption

• The active root-resorption lacunae from histological sections, identified by tartrate-resistant acid phosphatase, were measured in terms of length, depth, and area [7].
• Inhibitory effect of the topical administration of a bisphosphonate (risedronate) on root resorption incident to orthodontic tooth movement in rats [1].
• Extracted human deciduous teeth undergoing root resorption were fixed with a mixture of formaldehyde and glutaraldehyde and processed for immunocytochemical detection of these enzymes [8].
• However, when compared with samples taken from the fully formed root (six months), a higher activity of glucose-6-phosphate dehydrogenase and lactate dehydrogenase was found in samples taken from the root resorption phase (nine months) [9].
• We have studied the effects of sympathectomy and orthodontic tooth movement (OTM) on root resorption, immunocompetent cell recruitment, neuropeptide, neurokinin-1 receptor (NK1-R), and interleukin 6 (IL-6) expression [10].

Chemical compound and disease context of Root Resorption

• A significant shift towards ankylosis not associated with root resorption (greater than 80% of the total root surface area) was noted following calcium hydroxide treatment [11].
• The purpose of this study was to evaluate the effect of dexamethasone after delayed tooth replantation with specific regard to root resorption and ankylosis [12].
• Immunohistochemistry was performed using antibodies against the sensory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP), and measurements of root resorption and ankylosis were performed in four sections from each replanted tooth [13].

Biological context of Root Resorption

• It is possible that the PDL of the continuously erupting rat incisor has mechanical characteristics favourable for resisting weakly to slow and small eruptive forces but strongly to the fast and large occlusal forces as suggested previously [Chiba and Komatsu, The Biological Mechanisms of Tooth Eruption and Root Resorption (1988)] [14].
• Human deciduous teeth undergoing physiologic root resorption were extracted and fixed with a mixture of formaldehyde and glutaraldehyde and processed for scanning (SEM) and transmission (TEM) electron microscopy, and for acid (ACPase) and alkaline phosphatase (ALPase) cytochemistry [15].

Anatomical context of Root Resorption

• Collagenolytic activity of periodontal ligament and hydroxyproline content during human deciduous root resorption [16].
• CONCLUSIONS: These results demonstrate that PTHrP influences the balance of OPG and RANKL production by cementoblasts, and further indicate that this effect, in the context of surrounding cells, might have a significant impact on osteoclastogenesis, root resorption, and tooth eruption [17].
• METHODS: The effects of targeting the alphavbeta3 integrin receptor, expressed by odontoclasts, on induced root resorption surface areas and the number of root resorption lacunae were investigated by using an RGD-containing peptide, echistatin [18].
• The material, consisting of 1000 permanent teeth, excluding molars, was examined by means of a new scoring system (Surface Roughness Scores, SRS) for surface roughness, in addition to the scoring systems of Gustafson (RG) and Johanson (RJ) for root resorption [19].
• Inflammatory root resorption may be arrested by placement of calcium hydroxide into the root canal [20].

Associations of Root Resorption with chemical compounds

• These results suggest that the topical administration of risedronate may be useful in preventing root resorption of teeth during orthodontic treatment [1].
• The influence of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on dental root resorption in the mouse [21].
• Progressive cervical root resorption related to tetracycline root conditioning [22].
• Periodontal repair in dogs: effect of root surface treatment with stannous fluoride or citric acid on root resorption [23].
• The results showed that calcium hydroxide paste limited root resorption, even though not avoiding it [24].

Gene context of Root Resorption

• It was the aim of this study to examine the sites of expression of RANKL and RANK in the corresponding cells of human dental hard and periodontal tissues using immunohistochemical light microscopical methods on tissue sections of 15 paraffin-embedded human deciduous teeth undergoing root resorption [25].
• It was hypothesized that the ratios of RANKL to OPG expression would increase during root resorption processes [26].
• There was a wide range of unstimulated and stimulated IL-1 beta and TNF-alpha production by root resorption subject monocytes with no significant differences between resorption and nonresorption group means [27].
• Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa beta ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars [26].
• Iatrogenic effects of orthodontic treatment. Part I: Root resorption [28].

Analytical, diagnostic and therapeutic context of Root Resorption

• The use of a doxycycline immersion prior to reimplantation by the dentist may be helpful in preventing external root resorption [29].
• Fewer force-induced root resorption lesions occurred in the thyroxine group than in the control group [30].
• This study evaluated the amount and depth of root resorption associated with varying concentrations and frequencies of injectable, exogenous prostaglandin E2 (PGE2) in conjunction with orthodontic tooth movement in rats [31].
• A comparison of the approximate pretherapeutic alveolar bone height, which was assessed by measuring the distance from the cementoenamel junction to the most coronal margin of any root resorption in scanning electron microscopy, with that of the specimen showed a calculated bone loss on the lingual aspect extending from 2.3 to 6.9 mm [32].
• It is concluded that root resorption can be studied using a biochemical immunoassay and that this method can provide quantitative measurement of DPP in GCF [33].

References