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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Infection Control

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Disease relevance of Infection Control

  • To assess the extent to which US hospitals have established employee health services with infection control functions, we analyzed information obtained in the SENIC Project (Study on the Efficacy of Nosocomial Infection Control) from interviews with hospital officials and staff nurses in a representative sample of 433 hospitals [1].
  • For the control group, we randomly selected 33 patients with HIV-1 infection and isolation of a strain of M tuberculosis susceptible to isoniazid, rifampicin, or both, who were treated in Ramón y Cajal Hospital. Infection-control policies and practices were implemented [2].
  • Over the past 20 years there has been a greater interest in infection control in cystic fibrosis (CF) as patient-to-patient transmission of pathogens has been increasingly demonstrated in this unique patient population [3].
  • These mice all failed to ultimately control infection in the site, but in some cases (anti-CD4 treated, IL-12p40-/-, CD40 ligand-/-, and SCID) high dermal parasite loads were associated with little or no pathology [4].
  • Specific measures to control infection were effective in decreasing the incidence of infections caused by gentamicin-resistant Serratia [5].

Psychiatry related information on Infection Control


High impact information on Infection Control


Chemical compound and disease context of Infection Control


Biological context of Infection Control


Anatomical context of Infection Control

  • The level of two early proteins, glycoprotein B and glycoprotein D was reduced in one of the cell lines, however, levels were nearly equivalent to the control infection for two other cell lines tested [24].
  • CD8+ T cells can control infection by producing antiviral cytokines (e.g., gamma interferon or tumor necrosis factor alpha) or by triggering death of infected cells through perforin- or Fas ligand-dependent pathways [25].
  • These studies suggest that primary murine macrophages have limited ability to control infection with B. melitensis, even when activated by IFN-gamma in the presence of highly opsonic concentrations of antibody and complement [26].
  • Employment of such molecular methodologies, in conjunction with routine clinical sputum cultures, may provide improved information on the microbial status of CF patients, which will aid clinicians in both optimum patient management in terms of antibiotic regimes and CF centre infection-control practices [27].
  • In conclusion, this study demonstrates that with consistent infection control the postoperative exposure of PLA and PG-910 membranes has no significant negative effect on the regeneration outcome, although higher initial gingival recessions must be expected than in the nonexposed sites [28].

Associations of Infection Control with chemical compounds


Gene context of Infection Control

  • Moreover, in a mouse model requiring IL-12-dependent production of IFN-gamma, mice vaccinated with soluble Leishmania Ag and CD40LT DNA were able to control infection with Leishmania major [34].
  • Although CD40L(-/-) mice failed to control infection, CD28(-/-) and CD40L(-/-)CD28(-/-) mice, as well as C57BL/6 mice, spontaneously resolved their infections [35].
  • The ability of many microbial and inflammatory stimuli to activate members of the Rel/NF-kappaB family of transcription factors is associated with the regulation of innate and adaptive responses required to control infection [36].
  • A number of interventions have been demonstrated to abrogate Th2 cell development in BALB mice, enabling these mice to control infection [37].
  • Activin A-overexpression reduces neointima formation by 78%, whereas no significant reduction was observed after control infection [38].

Analytical, diagnostic and therapeutic context of Infection Control


  1. The employee health service and infection control in US hospitals, 1976-1977. I. Screening procedures. Haley, R.W., Emori, T.G. JAMA (1981) [Pubmed]
  2. Nosocomial transmission of Mycobacterium bovis resistant to 11 drugs in people with advanced HIV-1 infection. Guerrero, A., Cobo, J., Fortún, J., Navas, E., Quereda, C., Asensio, A., Cañón, J., Blazquez, J., Gómez-Mampaso, E. Lancet (1997) [Pubmed]
  3. Infection control in cystic fibrosis. Saiman, L., Siegel, J. Clin. Microbiol. Rev. (2004) [Pubmed]
  4. A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity. Belkaid, Y., Mendez, S., Lira, R., Kadambi, N., Milon, G., Sacks, D. J. Immunol. (2000) [Pubmed]
  5. Patient factors contributing to the emergence of gentamicin-resistant Serratia marcescens. Yu, V.L., Oakes, C.A., Axnick, K.J., Merigan, T.C. Am. J. Med. (1979) [Pubmed]
  6. Staphylococcus aureus bloodstream infections among patients undergoing electroconvulsive therapy traced to breaks in infection control and possible extrinsic contamination by propofol. Kuehnert, M.J., Webb, R.M., Jochimsen, E.M., Hancock, G.A., Arduino, M.J., Hand, S., Currier, M., Jarvis, W.R. Anesth. Analg. (1997) [Pubmed]
  7. AIDS: problem solving in infection control. Response to the human immunodeficiency virus epidemic: solutions from the Centers for Disease Control and Prevention and the infection control community. Valenti, W.M. American journal of infection control. (1993) [Pubmed]
  8. Detection of prion after decontamination procedures: comparative study of standard Western blot, filter retention and scrapie-cell assay. Solassol, J., Arlotto, M., Lehmann, S. J. Hosp. Infect. (2004) [Pubmed]
  9. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Hotchkiss, R.S., Chang, K.C., Swanson, P.E., Tinsley, K.W., Hui, J.J., Klender, P., Xanthoudakis, S., Roy, S., Black, C., Grimm, E., Aspiotis, R., Han, Y., Nicholson, D.W., Karl, I.E. Nat. Immunol. (2000) [Pubmed]
  10. Endogenous interleukin 4 is required for development of protective CD4+ T helper type 1 cell responses to Candida albicans. Mencacci, A., Del Sero, G., Cenci, E., d'Ostiani, C.F., Bacci, A., Montagnoli, C., Kopf, M., Romani, L. J. Exp. Med. (1998) [Pubmed]
  11. Clinical and molecular epidemiology of acinetobacter infections sensitive only to polymyxin B and sulbactam. Go, E.S., Urban, C., Burns, J., Kreiswirth, B., Eisner, W., Mariano, N., Mosinka-Snipas, K., Rahal, J.J. Lancet (1994) [Pubmed]
  12. Formalin in the urinary bag: a cheap measure to control infection in urology wards. Suryaprakash, B., Rao, M.S., Panigrahi, D., Vaidyanathan, S., Goel, A.K., Ayyagari, A. Lancet (1984) [Pubmed]
  13. An outbreak of Burkholderia (formerly Pseudomonas) cepacia respiratory tract colonization and infection associated with nebulized albuterol therapy. Hamill, R.J., Houston, E.D., Georghiou, P.R., Wright, C.E., Koza, M.A., Cadle, R.M., Goepfert, P.A., Lewis, D.A., Zenon, G.J., Clarridge, J.E. Ann. Intern. Med. (1995) [Pubmed]
  14. Frequency and possible infection control implications of gastrointestinal colonization with methicillin-resistant Staphylococcus aureus. Boyce, J.M., Havill, N.L., Maria, B. J. Clin. Microbiol. (2005) [Pubmed]
  15. Control of recurrent lower urinary tract infection in the postmenopausal woman. Parsons, C.L., Schmidt, J.D. J. Urol. (1982) [Pubmed]
  16. Molecular epidemiology of staphylococcal scalded skin syndrome in premature infants. Saiman, L., Jakob, K., Holmes, K.W., Whittier, S., Garzon, M.C., Rago, J.V., Schlievert, P.M., Della-Latta, P. Pediatr. Infect. Dis. J. (1998) [Pubmed]
  17. Preventing central venous catheter-related infection in a surgical intensive-care unit. Bijma, R., Girbes, A.R., Kleijer, D.J., Zwaveling, J.H. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (1999) [Pubmed]
  18. Ganciclovir therapy of symptomatic cytomegalovirus infection in renal transplant recipients. Guerin, C., Pozzetto, B., Broyet, C., Gaudin, O., Berthoux, F. Nephrol. Dial. Transplant. (1989) [Pubmed]
  19. HIV-related knowledge and precautions among Michigan nurses. Schillo, B.A., Reischl, T.M. American journal of public health. (1993) [Pubmed]
  20. APIC state-of-the-Art report: the role of infection control during construction in health care facilities. Bartley, J.M. American journal of infection control. (2000) [Pubmed]
  21. Consumer and market use of antibacterials at home. Rosenberg, S. Pediatr. Infect. Dis. J. (2000) [Pubmed]
  22. Antimicrobial susceptibility of inducible AmpC beta-lactamase-producing Enterobacteriaceae from the Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Programme, Europe 1997-2000. Pfaller, M.A., Jones, R.N. Int. J. Antimicrob. Agents (2002) [Pubmed]
  23. Infection control in the United Kingdom. Ayliffe, G.A. Chemotherapy. (1988) [Pubmed]
  24. The alpha protein ICP0 does not appear to play a major role in the regulation of herpes simplex virus gene expression during infection in tissue culture. Sandri-Goldin, R.M., Sekulovich, R.E., Leary, K. Nucleic Acids Res. (1987) [Pubmed]
  25. CD8+ T cells require perforin to clear West Nile virus from infected neurons. Shrestha, B., Samuel, M.A., Diamond, M.S. J. Virol. (2006) [Pubmed]
  26. Effects of opsonization and gamma interferon on growth of Brucella melitensis 16M in mouse peritoneal macrophages in vitro. Eze, M.O., Yuan, L., Crawford, R.M., Paranavitana, C.M., Hadfield, T.L., Bhattacharjee, A.K., Warren, R.L., Hoover, D.L. Infect. Immun. (2000) [Pubmed]
  27. Development of a diagnostic PCR assay that targets a heat-shock protein gene (groES) for detection of Pseudomonas spp. in cystic fibrosis patients. Clarke, L., Moore, J.E., Millar, B.C., Garske, L., Xu, J., Heuzenroeder, M.W., Crowe, M., Elborn, J.S. J. Med. Microbiol. (2003) [Pubmed]
  28. Postoperative exposure of bioresorbable GTR membranes: effect on healing results. Christgau, M., Bader, N., Schmalz, G., Hiller, K.A., Wenzel, A. Clinical oral investigations. (1997) [Pubmed]
  29. The enterococcus: "putting the bug in our ears". Hoffmann, S.A., Moellering, R.C. Ann. Intern. Med. (1987) [Pubmed]
  30. Nitric oxide in malaria: Indicator of disease severity and infection control. Taylor-Robinson, A. Parasitol. Today (Regul. Ed.) (1996) [Pubmed]
  31. Conventional versus interferon-gamma therapy in chronic granulomatous disease. Curnutte, J.T. J. Infect. Dis. (1993) [Pubmed]
  32. The galU Gene of Pseudomonas aeruginosa is required for corneal infection and efficient systemic spread following pneumonia but not for infection confined to the lung. Priebe, G.P., Dean, C.R., Zaidi, T., Meluleni, G.J., Coleman, F.T., Coutinho, Y.S., Noto, M.J., Urban, T.A., Pier, G.B., Goldberg, J.B. Infect. Immun. (2004) [Pubmed]
  33. Patterns and mechanisms of emergence of resistance to amikacin. Meyer, R.D. J. Infect. Dis. (1977) [Pubmed]
  34. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge. Gurunathan, S., Irvine, K.R., Wu, C.Y., Cohen, J.I., Thomas, E., Prussin, C., Restifo, N.P., Seder, R.A. J. Immunol. (1998) [Pubmed]
  35. The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation. Padigel, U.M., Perrin, P.J., Farrell, J.P. J. Immunol. (2001) [Pubmed]
  36. T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii. Mason, N.J., Liou, H.C., Hunter, C.A. J. Immunol. (2004) [Pubmed]
  37. The development of effector T cell subsets in murine Leishmania major infection. Locksley, R.M., Wakil, A.E., Corry, D.B., Pingel, S., Bix, M., Fowell, D.J. Ciba Found. Symp. (1995) [Pubmed]
  38. Adenoviral activin a expression prevents intimal hyperplasia in human and murine blood vessels by maintaining the contractile smooth muscle cell phenotype. Engelse, M.A., Lardenoye, J.H., Neele, J.M., Grimbergen, J.M., De Vries, M.R., Lamfers, M.L., Pannekoek, H., Quax, P.H., De Vries, C.J. Circ. Res. (2002) [Pubmed]
  39. Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: fitting a model to the data. Grundmann, H., Hori, S., Winter, B., Tami, A., Austin, D.J. J. Infect. Dis. (2002) [Pubmed]
  40. Graft-preserving treatment for vascular graft infected with Staphylococcus aureus with antibiotic-releasing porous apatite ceramic in the rabbit. Murase, K., Hirose, H., Mori, Y., Takagi, H., Iwata, H., Sago, T., Kawamura, Y. J. Vasc. Surg. (2003) [Pubmed]
  41. 0.25% chlorhexidine gluconate gel. A protective topical microbicide. Patton, D.L., Sweeney, Y.T., McKay, T.L., DeMers, S.M., Clark, A.M., Rabe, L.K., Hillier, S.L. Sexually transmitted diseases. (1998) [Pubmed]
  42. Distribution of genes encoding putative transmissibility factors among epidemic and nonepidemic strains of Burkholderia cepacia from cystic fibrosis patients in the United Kingdom. Clode, F.E., Kaufmann, M.E., Malnick, H., Pitt, T.L. J. Clin. Microbiol. (2000) [Pubmed]
  43. Impact on knowledge and practice of a multiregional long-term care facility infection control training program. Daly, P.B., Smith, P.W., Rusnak, P.G., Jones, M.B., Giuliano, D. American journal of infection control. (1992) [Pubmed]
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