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MeSH Review


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Disease relevance of Peristalsis


Psychiatry related information on Peristalsis


High impact information on Peristalsis


Chemical compound and disease context of Peristalsis


Biological context of Peristalsis


Anatomical context of Peristalsis

  • After GER the esophagus was generally cleared of refluxed acid by primary peristalsis and less frequently by secondary peristalsis [22].
  • (2) L-NMMA given ICV significantly reduced the number of oropharyngeal swallows and the incidence of primary peristalsis in both smooth and striated muscle, but the reduction in amplitude was significant only for the smooth muscle contraction [23].
  • Recent human studies suggest that oesophageal HCO3- secretion, in conjunction with salivary HCO3- secretion and secondary oesophageal peristalsis, is important for the protection of oesophageal mucosa from refluxed gastric contents [24].
  • It is concluded that P2X3 subunit-containing receptors participate in neural pathways underlying peristalsis in the mouse intestine in vitro [25].
  • RESULTS: CCh (0.1 to 1.0 microg/kg intravenously) dose dependently decreased elevated pressure and peristalsis in completely and partially obstructed ureters, respectively, and increased intravesical isovolumetric pressure [26].

Associations of Peristalsis with chemical compounds

  • Radiologically, segmental tertiary activity (complete luminal obliteration) was always associated with disrupted primary peristalsis, but nonsegmental tertiary activity was often seen with normal bolus transit and did not have a specific manometric correlate [27].
  • METHODS: (1) The effect of intravenous (IV) NOS inhibitor N(G)-nitro-L-arginine (L-NNA) on swallowing and swallowing-induced peristalsis was examined [23].
  • There were no changes in sphincter relaxation or in peristalsis, velocity, or duration of contraction with any dose of nifedipine [28].
  • BACKGROUND & AIMS: Nitric oxide controls lower esophageal sphincter (LES) relaxation and esophageal peristalsis in opossums, but its role in the control of esophageal motility in humans is not defined [29].
  • The effect of L-NMMA was evaluated on water swallow-evoked primary peristalsis (n = 8; single-blind, placebo-controlled) and on the rate of TLESRs during gastric distention (n = 8; double-blind, placebo-controlled) [30].

Gene context of Peristalsis

  • NT-3 is required for the differentiation, maintenance and proper physiological function of late-developing enteric neurons that are important for the control of gut peristalsis [31].
  • Small (nanomolar) quantities of NO produced by calcium-dependent nNOS play a physiological role in peristalsis and sphincter function of the intestine [32].
  • In summary, NK1 receptors play a role in normal development of peristalsis and NK1 receptor activation markedly increases propulsive peristaltic contractile activity [33].
  • c-kit and ureteral peristalsis [34].
  • Inhibition of motility by CGRP could be important for setting the frequency of ureteral peristalsis and suppression of latent pacemakers to prevent the occurrence of antiperistaltic waves [35].

Analytical, diagnostic and therapeutic context of Peristalsis


  1. Salutary role for angiotensin in partial urinary tract obstruction. Fujinaka, H., Miyazaki, Y., Matsusaka, T., Yoshida, H., Fogo, A.B., Inagami, T., Ichikawa, I. Kidney Int. (2000) [Pubmed]
  2. Return of esophageal peristalsis after nifedipine therapy in patients with idiopathic esophageal achalasia. Coccia, G., Bortolotti, M., Michetti, P., Dodero, M. Am. J. Gastroenterol. (1992) [Pubmed]
  3. Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction. Trevisani, G.T., Hyman, N.H., Church, J.M. Dis. Colon Rectum (2000) [Pubmed]
  4. Treatment of morbid obesity with laparoscopic adjustable gastric banding affects esophageal motility. Weiss, H.G., Nehoda, H., Labeck, B., Peer-Kühberger, M.D., Klingler, P., Gadenstätter, M., Aigner, F., Wetscher, G.J. Am. J. Surg. (2000) [Pubmed]
  5. Co-localization of NOS and NMDA receptor in esophageal premotor neurons of the rat. Broussard, D.L., Bao, X., Li, X., Altschuler, S.M. Neuroreport (1995) [Pubmed]
  6. Motor activity of the rat duodenum in vivo: evidence for the existence of an atropine-resistant peristalsis. Maggi, C.A., Santicioli, P., Giuliani, S., Meli, A. Gen. Pharmacol. (1987) [Pubmed]
  7. A comparison of virtual and conventional colonoscopy for the detection of colorectal polyps. Fenlon, H.M., Nunes, D.P., Schroy, P.C., Barish, M.A., Clarke, P.D., Ferrucci, J.T. N. Engl. J. Med. (1999) [Pubmed]
  8. Experimental induction of isolated lower esophageal sphincter relaxation in anesthetized opossums. Paterson, W.G., Rattan, S., Goyal, R.K. J. Clin. Invest. (1986) [Pubmed]
  9. Brain-derived neurotrophic factor augments peristalsis by augmenting 5-HT and calcitonin gene-related peptide release. Grider, J.R., Piland, B.E., Gulick, M.A., Qiao, L.Y. Gastroenterology (2006) [Pubmed]
  10. 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum. Tonini, M., Vicini, R., Cervio, E., De Ponti, F., De Giorgio, R., Barbara, G., Stanghellini, V., Dellabianca, A., Sternini, C. Gastroenterology (2005) [Pubmed]
  11. Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon. Tonini, M., Spelta, V., De Ponti, F., De Giorgio, R., D'Agostino, G., Stanghellini, V., Corinaldesi, R., Sternini, C., Crema, F. Gastroenterology (2001) [Pubmed]
  12. US of gastrointestinal tract abnormalities with CT correlation. O'Malley, M.E., Wilson, S.R. Radiographics : a review publication of the Radiological Society of North America, Inc. (2003) [Pubmed]
  13. Cisapride as a treatment for gastroparesis in traumatic brain injury. Altmayer, T., O'Dell, M.W., Jones, M., Martin, V., Hawkins, H.H. Archives of physical medicine and rehabilitation. (1996) [Pubmed]
  14. Alteration of esophageal peristalsis by pentagastrin in patients with diffuse esophageal spasm. Eckhardt, V.F., Krüger, J., Holtermüller, K.H., Ewe, K. Scand. J. Gastroenterol. (1975) [Pubmed]
  15. Neostigmine, but not metoclopramide, abolishes ethosuximide-induced functional gastrointestinal disturbances. Sirakov, V., Krastev, A., Kostadinova, I., Turiiski, V. Pharmacology (2005) [Pubmed]
  16. Evaluation of some risks factors in bovine salmonellosis. Morisse, J.P., Cotte, J.P. Vet. Res. (1994) [Pubmed]
  17. Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages. Vazquez-Torres, A., Jones-Carson, J., Balish, E. Infect. Immun. (1996) [Pubmed]
  18. Substance P and calcitonin gene-related peptide in the ureter of chicken and guinea-pig: distribution, binding sites and possible functions. Sann, H., Rössler, W., Hammer, K., Pierau, F.K. Neuroscience (1992) [Pubmed]
  19. Despite expression in embryonic visceral mesoderm, H2.0 is not essential for Drosophila visceral muscle morphogenesis. Barad, M., Erlebacher, A., McGinnis, W. Dev. Genet. (1991) [Pubmed]
  20. Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors. Shahbazian, A., Schuligoi, R., Heinemann, A., Peskar, B.A., Holzer, P. Br. J. Pharmacol. (2001) [Pubmed]
  21. Effect of bethanechol and metoclopramide on upper gastrointestinal motility in the kitten. Hillemeier, C., McCallum, R., Oertel, R., Gryboski, J. J. Pediatr. Gastroenterol. Nutr. (1986) [Pubmed]
  22. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. Dent, J., Dodds, W.J., Friedman, R.H., Sekiguchi, T., Hogan, W.J., Arndorfer, R.C., Petrie, D.J. J. Clin. Invest. (1980) [Pubmed]
  23. Central nervous system nitric oxide induces oropharyngeal swallowing and esophageal peristalsis in the cat. Beyak, M.J., Xue, S., Collman, P.I., Valdez, D.T., Diamant, N.E. Gastroenterology (2000) [Pubmed]
  24. Effect of topical oesophageal acidification on human salivary and oesophageal alkali secretion. Brown, C.M., Snowdon, C.F., Slee, B., Sandle, L.N., Rees, W.D. Gut (1995) [Pubmed]
  25. Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit. Bian, X., Ren, J., DeVries, M., Schnegelsberg, B., Cockayne, D.A., Ford, A.P., Galligan, J.J. J. Physiol. (Lond.) (2003) [Pubmed]
  26. Effects of cholinergic drugs on ureteral function in anesthetized dogs. Tomiyama, Y., Wanajo, I., Yamazaki, Y., Kojima, M., Shibata, N. J. Urol. (2004) [Pubmed]
  27. Manometry and radiology. Complementary studies in the assessment of esophageal motility disorders. Hewson, E.G., Ott, D.J., Dalton, C.B., Chen, Y.M., Wu, W.C., Richter, J.E. Gastroenterology (1990) [Pubmed]
  28. Effects of nifedipine on esophageal motor function in humans: correlation with plasma nifedipine concentration. Hongo, M., Traube, M., McAllister, R.G., McCallum, R.W. Gastroenterology (1984) [Pubmed]
  29. The effects of recombinant human hemoglobin on esophageal motor functions in humans. Murray, J.A., Ledlow, A., Launspach, J., Evans, D., Loveday, M., Conklin, J.L. Gastroenterology (1995) [Pubmed]
  30. Involvement of nitric oxide in human transient lower esophageal sphincter relaxations and esophageal primary peristalsis. Hirsch, D.P., Holloway, R.H., Tytgat, G.N., Boeckxstaens, G.E. Gastroenterology (1998) [Pubmed]
  31. Neurotrophin-3 in the development of the enteric nervous system. Chalazonitis, A. Prog. Brain Res. (2004) [Pubmed]
  32. Targeting nitric oxide in the gastrointestinal tract. Dijkstra, G., van Goor, H., Jansen, P.L., Moshage, H. Current opinion in investigational drugs (London, England : 2000) (2004) [Pubmed]
  33. Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal. Nieuwmeyer, F., Ye, J., Huizinga, J.D. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  34. c-kit and ureteral peristalsis. David, S.G., Cebrian, C., Vaughan, E.D., Herzlinger, D. J. Urol. (2005) [Pubmed]
  35. Calcitonin gene-related peptide (CGRP) regulates excitability and refractory period of the guinea pig ureter. Maggi, C.A., Giuliani, S. J. Urol. (1994) [Pubmed]
  36. Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs. Dilawari, J.B., Newman, A., Poleo, J., Misiewicz, J.J. Gut (1975) [Pubmed]
  37. Gastroesophageal reflux associated with nemaline myopathy of infancy. Berezin, S., Newman, L.J., Schwarz, S.M., Spiro, A.J. Pediatrics (1988) [Pubmed]
  38. Metoclopramide effect on esophageal peristalsis in normal human volunteers. DiPalma, J.A., Perucca, P.J., Martin, D.F., Pierson, W.P., Meyer, G.W. Am. J. Gastroenterol. (1987) [Pubmed]
  39. Improved pyeloureteral visualization using glucagon during experimental intravenous urography. Hillman, B.J., Ovitt, T.W., Doering, J.W. Investigative radiology. (1980) [Pubmed]
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