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Gene Review

Cldn5  -  claudin 5

Mus musculus

Synonyms: AI854493, Bec1, Brain endothelial cell clone 1 protein, Claudin-5, Lung-specific membrane protein, ...
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Disease relevance of Cldn5

  • These data demonstrate that claudin-5 is specifically altered in dko hearts, suggesting that alterations of the lateral membranes of cardiomyocytes, rather than intercalated discs, are associated with cardiomyopathy in the dko mouse [1].
  • Among these, claudin-5 (also called transmembrane protein deleted in velo-cardio-facial syndrome [TMVCF]) was expressed ubiquitously, even in organs lacking epithelial tissues, suggesting the possible involvement of this claudin species in endothelial TJs [2].
  • Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability [3].
  • These in vitro and in vivo data indicate that claudin-5 is a target molecule of hypoxia leading to the disruption of the barrier function of neural vasculature [4].
  • When injected subcutaneously in nude mice, MAECs induced the appearance of slow-growing vascular lesions reminiscent of epithelioid hemangioendothelioma, whereas MBEC xenografts grew rapidly, showing Kaposi's sarcoma-like morphological features [5].

High impact information on Cldn5


Chemical compound and disease context of Cldn5

  • Luminal to abluminal PMT of 131I-HIV-1 was 4.65 times greater than that of the much smaller 131I-BSA, showing that the MBEC monolayer is more permeable to HIV-1 than to BSA [8].

Biological context of Cldn5

  • Transfection of TR-BBB cells with the claudin-5 gene afforded TR-BBB/CLD5 cells, which showed no change in expression of claudin-12 or ZO-1, while the expressed claudin-5 was detected at the cell-cell boundaries [9].
  • In conclusion, disruptions of the tight junctions observed in this study implicate host cell signaling pathways, including the phosphorylation of myosin light chain and the regulation of tight-junctional proteins claudin-4 and claudin-5, in the pathogenesis of H. pylori infection [3].
  • The movement of claudin-5 from the cytoplasm to the plasma membrane of cultured confluent brain-derived endothelial (bEND.3) cells was closely correlated with the increase in the transendothelial electrical resistance [4].
  • Tracer experiments revealed that the barrier function of hypoxic retinal vasculature with depressed claudin-5 expression was selectively disrupted against small molecules, which is very similar to the phenotype of claudin-5-deficient mice [4].
  • Wheatgerm agglutinin (WGA) increased 131I-HIV-1 penetration across the MBEC monolayer, consistent with absorptive endocytosis as the mechanism for HIV-1 penetration [8].

Anatomical context of Cldn5


Associations of Cldn5 with chemical compounds


Other interactions of Cldn5


Analytical, diagnostic and therapeutic context of Cldn5


  1. Claudin-5 localizes to the lateral membranes of cardiomyocytes and is altered in utrophin/dystrophin-deficient cardiomyopathic mice. Sanford, J.L., Edwards, J.D., Mays, T.A., Gong, B., Merriam, A.P., Rafael-Fortney, J.A. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  2. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. Morita, K., Sasaki, H., Furuse, M., Tsukita, S. J. Cell Biol. (1999) [Pubmed]
  3. Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Fedwick, J.P., Lapointe, T.K., Meddings, J.B., Sherman, P.M., Buret, A.G. Infect. Immun. (2005) [Pubmed]
  4. Hypoxia Disrupts the Barrier Function of Neural Blood Vessels through Changes in the Expression of Claudin-5 in Endothelial Cells. Koto, T., Takubo, K., Ishida, S., Shinoda, H., Inoue, M., Tsubota, K., Okada, Y., Ikeda, E. Am. J. Pathol. (2007) [Pubmed]
  5. Basic fibroblast growth factor-induced angiogenic phenotype in mouse endothelium. A study of aortic and microvascular endothelial cell lines. Bastaki, M., Nelli, E.E., Dell'Era, P., Rusnati, M., Molinari-Tosatti, M.P., Parolini, S., Auerbach, R., Ruco, L.P., Possati, L., Presta, M. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  6. TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. Watabe, T., Nishihara, A., Mishima, K., Yamashita, J., Shimizu, K., Miyazawa, K., Nishikawa, S., Miyazono, K. J. Cell Biol. (2003) [Pubmed]
  7. Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Wen, H., Watry, D.D., Marcondes, M.C., Fox, H.S. Mol. Cell. Biol. (2004) [Pubmed]
  8. Human immunodeficiency virus type 1 transport across the in vitro mouse brain endothelial cell monolayer. Nakaoke, R., Ryerse, J.S., Niwa, M., Banks, W.A. Exp. Neurol. (2005) [Pubmed]
  9. Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cells. Ohtsuki, S., Sato, S., Yamaguchi, H., Kamoi, M., Asashima, T., Terasaki, T. J. Cell. Physiol. (2007) [Pubmed]
  10. Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice. Troy, T.C., Rahbar, R., Arabzadeh, A., Cheung, R.M., Turksen, K. Mech. Dev. (2005) [Pubmed]
  11. Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation. Gurney, K.J., Estrada, E.Y., Rosenberg, G.A. Neurobiol. Dis. (2006) [Pubmed]
  12. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. Sirotkin, H., Morrow, B., Saint-Jore, B., Puech, A., Das Gupta, R., Patanjali, S.R., Skoultchi, A., Weissman, S.M., Kucherlapati, R. Genomics (1997) [Pubmed]
  13. GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter. Kannan, R., Mittur, A., Bao, Y., Tsuruo, T., Kaplowitz, N. J. Neurochem. (1999) [Pubmed]
  14. A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. Nasdala, I., Wolburg-Buchholz, K., Wolburg, H., Kuhn, A., Ebnet, K., Brachtendorf, G., Samulowitz, U., Kuster, B., Engelhardt, B., Vestweber, D., Butz, S. J. Biol. Chem. (2002) [Pubmed]
  15. Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells. Brown, R.C., Morris, A.P., O'neil, R.G. Brain Res. (2007) [Pubmed]
  16. Expression of claudin-5 in dermal vascular endothelia. Morita, K., Sasaki, H., Furuse, K., Furuse, M., Tsukita, S., Miyachi, Y. Exp. Dermatol. (2003) [Pubmed]
  17. Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors. Chen, Z., Zandonatti, M., Jakubowski, D., Fox, H.S. Lab. Invest. (1998) [Pubmed]
  18. Enhanced expression by the brain matrix of P-glycoprotein in brain capillary endothelial cells. Tatsuta, T., Naito, M., Mikami, K., Tsuruo, T. Cell Growth Differ. (1994) [Pubmed]
  19. Angiogenesis: the major abnormality of the keratin-14 IL-4 transgenic mouse model of atopic dermatitis. Agha-Majzoub, R., Becker, R.P., Schraufnagel, D.E., Chan, L.S. Microcirculation (New York, N.Y. : 1994) (2005) [Pubmed]
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