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Gene Review

Ergic1  -  endoplasmic reticulum-golgi intermediate...

Mus musculus

Synonyms: 1200007D18Rik, ER-Golgi intermediate compartment 32 kDa protein, ERGIC-32, Endoplasmic reticulum-Golgi intermediate compartment protein 1, Ergic32, ...
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Disease relevance of Ergic1


High impact information on Ergic1


Biological context of Ergic1


Anatomical context of Ergic1

  • When synthesis of the 21-kDa protein is repressed, organized membranes are not formed but numerous ERGIC-derived tubulovesicular structures containing the 15-kDa protein accumulate in the boundaries of the precursors of the viral factories [7].
  • The CLN8 transmembrane protein is an endoplasmic reticulum (ER) resident protein that recycles between ER and ER-Golgi intermediate compartment (ERGIC) in non-neuronal cells [8].
  • Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus [9].

Associations of Ergic1 with chemical compounds

  • PS1 distribution showed slight condensation after brefeldin A and more marked condensation after incubation of cells at 16 degrees C, characteristic of the ERGIC compartment [10].
  • The results of the present study seem to give some support to the notion that not only NMDA receptors, but also CCK-ergic mechanisms are involved in the modulation of anti-exploratory action of NMDA in the elevated plus-maze [11].
  • Aminorex and its analogues, with exception of 4S, 5S-dimethylaminorex, did not cause the long-term neurotransmitter depletion in either the dopaminergic or 5-HT-ergic systems that was observed after MDMA or fenfluramine in CBA mice [12].
  • The firing of 5-HT-ergic dorsal raphe neurons in rats was decreased after intravenous administration of low doses of 403U76 as would be predicted for a 5-HT uptake inhibitor [13].

Other interactions of Ergic1

  • These data suggest that feeding induced by weakening of the MC4R-ergic tone may be mediated through activation of the NPY-ergic system [14].
  • SV was found to activate CRH- and arginine vasopressin-ergic functions in vivo and, in vitro, SV and PLA2 induced a concentration-related (0.05-10 microg/ml) effect on the release of both neuropeptides [15].
  • Perfusion of bicarbonate-free saline has no detectable influence on EGABA-A, indicating that a lack of Cl- extrusion during P0-3 is mainly responsible for early GABAA-ergic excitation [16].


  1. Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Tortoriello, D.V., McMinn, J., Chua, S.C. Endocrinology (2004) [Pubmed]
  2. Y4 receptor knockout rescues fertility in ob/ob mice. Sainsbury, A., Schwarzer, C., Couzens, M., Jenkins, A., Oakes, S.R., Ormandy, C.J., Herzog, H. Genes Dev. (2002) [Pubmed]
  3. The lectin ERGIC-53 is a cargo transport receptor for glycoproteins. Appenzeller, C., Andersson, H., Kappeler, F., Hauri, H.P. Nat. Cell Biol. (1999) [Pubmed]
  4. Separate roles and different routing of calnexin and ERp57 in endoplasmic reticulum quality control revealed by interactions with asialoglycoprotein receptor chains. Frenkel, Z., Shenkman, M., Kondratyev, M., Lederkremer, G.Z. Mol. Biol. Cell (2004) [Pubmed]
  5. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. Gorbea, C., Goellner, G.M., Teter, K., Holmes, R.K., Rechsteiner, M. J. Biol. Chem. (2004) [Pubmed]
  6. Neuronal localization of pyroglutamate aminopeptidase II in primary cultures of fetal mouse brain. Cruz, C., Charli, J.L., Vargas, M.A., Joseph-Bravo, P. J. Neurochem. (1991) [Pubmed]
  7. Characterization of early stages in vaccinia virus membrane biogenesis: implications of the 21-kilodalton protein and a newly identified 15-kilodalton envelope protein. Rodríguez, J.R., Risco, C., Carrascosa, J.L., Esteban, M., Rodríguez, D. J. Virol. (1997) [Pubmed]
  8. Localization of wild-type and mutant neuronal ceroid lipofuscinosis CLN8 proteins in non-neuronal and neuronal cells. Lonka, L., Salonen, T., Siintola, E., Kopra, O., Lehesjoki, A.E., Jalanko, A. J. Neurosci. Res. (2004) [Pubmed]
  9. Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. Sun, Q.Q., Baraban, S.C., Prince, D.A., Huguenard, J.R. J. Neurosci. (2003) [Pubmed]
  10. Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment. Culvenor, J.G., Maher, F., Evin, G., Malchiodi-Albedi, F., Cappai, R., Underwood, J.R., Davis, J.B., Karran, E.H., Roberts, G.W., Beyreuther, K., Masters, C.L. J. Neurosci. Res. (1997) [Pubmed]
  11. Anti-exploratory effect of N-methyl-D-aspartate in elevated plus-maze. Involvement of NMDA and CCK receptors. Vasar, E., Harro, J., Lang, A., Soosaar, A., Oöpik, T., Kôks, S., Sihver, S., Volke, V. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1993) [Pubmed]
  12. The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice. Zheng, Y., Russell, B., Schmierer, D., Laverty, R. J. Pharm. Pharmacol. (1997) [Pubmed]
  13. Pharmacological properties of 403U76, a new chemical class of 5-hydroxytryptamine- and noradrenaline-reuptake inhibitor. Ferris, R.M., Brieaddy, L., Mehta, N., Hollingsworth, E., Rigdon, G., Wang, C., Soroko, F., Wastila, W., Cooper, B. J. Pharm. Pharmacol. (1995) [Pubmed]
  14. Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y. Kask, A., Rägo, L., Korrovits, P., Wikberg, J.E., Schiöth, H.B. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  15. A phospholipase A2-related snake venom (from Crotalus durissus terrificus) stimulates neuroendocrine and immune functions: determination of different sites of action. Chisari, A., Spinedi, E., Voirol, M.J., Giovambattista, A., Gaillard, R.C. Endocrinology (1998) [Pubmed]
  16. Early postnatal maturation of GABAA-mediated inhibition in the brainstem respiratory rhythm-generating network of the mouse. Ritter, B., Zhang, W. Eur. J. Neurosci. (2000) [Pubmed]
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