The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Avp  -  arginine vasopressin

Mus musculus

Synonyms: AVP-NPII, Vasopressin-neurophysin 2-copeptin, Vp, Vsp
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Avp


Psychiatry related information on Avp


High impact information on Avp


Chemical compound and disease context of Avp


Biological context of Avp


Anatomical context of Avp

  • AVP-induced vasopressor responses were abolished in the mutant mice; rather, AVP caused a decrease in BP, which occurred in part through V2 receptor-mediated release of nitric oxide from the vascular endothelium [19].
  • AVP messenger RNA expression was increased in the paraventricular nucleus of Crhr1-/- mutants together with a marked increase in AVP-like immunoreactivity in the median eminence [22].
  • The AVP replacement did not stimulate DNA synthesis in the target lymphocytes [23].
  • These data indicate developmental changes in the steroidogenic responsiveness of Leydig cells to neurohypophysial hormones and suggest that AVP receptors might be under a regulatory mechanism(s) during puberty [24].
  • These data suggest that PGE(2) modulates urine concentration by acting at EP(1) receptors, not in the collecting duct, but within the hypothalamus to promote AVP synthesis in response to acute WD [25].

Associations of Avp with chemical compounds

  • To investigate the role of Avp in the hypothalamic-pituitary-adrenal axis response to stress, we measured plasma ACTH and corticosterone (CORT) levels in Avpr1b knockout (KO) mice and wild-type controls in response to two acute (restraint and insulin administration) and one form of chronic (daily restraint for 14 d) stress [26].
  • Developmental changes in arginine vasopressin receptors and testosterone stimulation in Leydig cells [24].
  • The AVP RIA can detect as little as 2 pg hormone and shows essentially no cross-reactivity with AVT or OT [27].
  • The chicken pineal also contained AVT (about 300 pg/gland) and lacked AVP and OT [27].
  • Cycloheximide totally abolished the AVP stimulation, suggesting that the AVP effect is dependent upon new protein synthesis [24].

Physical interactions of Avp


Regulatory relationships of Avp

  • Interval mapping on chromosome 7 reveals substantial overlap between QTL that control AVP and Crf-R1 transcript abundance and on chromosome 12 for QTL that control CRF and Crf-R1, which may indicate loci that coordinate regulation of the CRF system [29].
  • Our studies suggest that, at the hypothalamic level, CRH synthesis is the major target for feedback control by the GR and that transcriptional control of AVP and neurophysin plays only a supportive role in this process [30].
  • Here we report, for the first time, that AVP specifically inhibits expression of the cyclin D1 gene, leading to cell cycle blockage and halting cell proliferation [31].
  • Thus, AVP and FGF2 concur to activate ERK1/2 by different regulatory pathways [31].
  • Arginine vasopressin induces the expression of c-fos in the mouse septum and hippocampus [32].

Other interactions of Avp

  • Arginine-vasopressin (AVP) is a hormone that is essential for both osmotic and cardiovascular homeostasis, and exerts important physiological regulation through three distinct receptors, V1a, V1b, and V2 [19].
  • Basal plasma AVP concentrations were significantly elevated in Crhr1-/- mice [22].
  • In situ hybridization histochemistry revealed that estrogen treatment resulted in a significant increase in OT transcripts (151.6+/-6.0%) and a decrease in AVP transcripts (77.8+/-5.2%) in the PVN of WT mice, compared to the placebo control group [21].
  • Hypertonicity regulates the aquaporin-2 promoter independently of arginine vasopressin [33].
  • There was no additive effect of ET-1 and AVP on [Ca2+]i when they were added together [34].

Analytical, diagnostic and therapeutic context of Avp

  • This deficit could be traced back to a blunted induction of hypothalamic AVP mRNA expression in WD EP(1)(-/-) mice as determined by quantitative RT-PCR [25].
  • The determination of NO-synthesizing neurons was performed by double immunohistochemistry for the neuronal form of NO synthase (NOS), and AVP or OT [35].
  • In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry [36].
  • None of the antagonists used blocked AVP-induced analgesia [37].
  • After hypophysectomy, both AVP- and OXT-immunoreactive neurons showed an intense stainability 10 days after the operation regardless of ages [38].


  1. A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons. Russell, T.A., Ito, M., Ito, M., Yu, R.N., Martinson, F.A., Weiss, J., Jameson, J.L. J. Clin. Invest. (2003) [Pubmed]
  2. Morphology of adenohypophysial tumors in mice transgenic for vasopressin-SV40 hybrid oncogene. Stefaneanu, L., Rindi, G., Horvath, E., Murphy, D., Polak, J.M., Kovacs, K. Endocrinology (1992) [Pubmed]
  3. Gene therapy in the neuroendocrine system. Hereñú, C.B., Morel, G.R., Bellini, M.J., Reggiani, P.C., Sosa, Y.E., Brown, O.A., Goya, R.G. Frontiers of hormone research. (2006) [Pubmed]
  4. Neuropeptide modulation of social and exploratory behaviors in laboratory rodents. Crawley, J.N., Hays, S.E., O'Donohue, T.L., Paul, S.M., Goodwin, F.K. Peptides (1981) [Pubmed]
  5. Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Chou, C.L., Ma, T., Yang, B., Knepper, M.A., Verkman, A.S. Am. J. Physiol. (1998) [Pubmed]
  6. Lack of the development of morphine tolerance in experimental amnesia: role of arginine vasopressin. Sugimachi, N., Nakamura, T., Takahashi, M., Kaneto, H. Brain Res. (1993) [Pubmed]
  7. Vasopressin and the transmission of paternal behavior across generations in mated, cross-fostered Peromyscus mice. Bester-Meredith, J.K., Marler, C.A. Behav. Neurosci. (2003) [Pubmed]
  8. Facilitation of retention performance in mice by pretest microinjection of AVP into dorsal or ventral hippocampus: differential influence of the peptide on appetitive task. Metzger, D., Alescio-Lautier, B., Soumireu-Mourat, B. Neurosci. Lett. (1989) [Pubmed]
  9. Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole. Young, L.J., Nilsen, R., Waymire, K.G., MacGregor, G.R., Insel, T.R. Nature (1999) [Pubmed]
  10. Arginine vasopressin maintains ethanol tolerance. Hoffman, P.L., Ritzmann, R.F., Walter, R., Tabakoff, B. Nature (1978) [Pubmed]
  11. Corticotropin-releasing activity of monokines. Woloski, B.M., Smith, E.M., Meyer, W.J., Fuller, G.M., Blalock, J.E. Science (1985) [Pubmed]
  12. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Naeini, R.S., Witty, M.F., Séguéla, P., Bourque, C.W. Nat. Neurosci. (2006) [Pubmed]
  13. Dominant-negative diabetes insipidus and other endocrinopathies. Phillips, J.A. J. Clin. Invest. (2003) [Pubmed]
  14. Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. Morimoto, S., Cassell, M.D., Sigmund, C.D. J. Biol. Chem. (2002) [Pubmed]
  15. Improvement of cationic albumin conjugated pegylated nanoparticles holding NC-1900, a vasopressin fragment analog, in memory deficits induced by scopolamine in mice. Xie, Y.L., Lu, W., Jiang, X.G. Behav. Brain Res. (2006) [Pubmed]
  16. ADH and related peptides: effect of pre- or posttraining treatment on puromycin amnesia. Flexner, J.B., Flexner, L.B., Walter, R., Hoffman, P.L. Pharmacol. Biochem. Behav. (1978) [Pubmed]
  17. Vasopressin mediates neuroprotection in mice by stimulation of V1 vasopressin receptors: influence of PI-3 kinase and gap junction inhibitors. Tyagi, M.G., Parthiban, K.V. Indian J. Exp. Biol. (2003) [Pubmed]
  18. The pituitary hormones arginine vasopressin-neurophysin II and oxytocin-neurophysin I show close linkage with interleukin-1 on mouse chromosome 2. Marini, J.C., Nelson, K.K., Battey, J., Siracusa, L.D. Genomics (1993) [Pubmed]
  19. V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Koshimizu, T.A., Nasa, Y., Tanoue, A., Oikawa, R., Kawahara, Y., Kiyono, Y., Adachi, T., Tanaka, T., Kuwaki, T., Mori, T., Takeo, S., Okamura, H., Tsujimoto, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  20. Localization and characterization of binding sites for vasopressin and oxytocin in the brain of the guinea pig. Tribollet, E., Barberis, C., Dubois-Dauphin, M., Dreifuss, J.J. Brain Res. (1992) [Pubmed]
  21. Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice. Nomura, M., McKenna, E., Korach, K.S., Pfaff, D.W., Ogawa, S. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  22. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Müller, M.B., Landgraf, R., Preil, J., Sillaber, I., Kresse, A.E., Keck, M.E., Zimmermann, S., Holsboer, F., Wurst, W. Endocrinology (2000) [Pubmed]
  23. Vasopressin replacement of interleukin 2 requirement in gamma interferon production: lymphokine activity of a neuroendocrine hormone. Johnson, H.M., Farrar, W.L., Torres, B.A. J. Immunol. (1982) [Pubmed]
  24. Developmental changes in arginine vasopressin receptors and testosterone stimulation in Leydig cells. Tahri-Joutei, A., Pointis, G. Endocrinology (1989) [Pubmed]
  25. Urine concentrating defect in prostaglandin EP1-deficient mice. Kennedy, C.R., Xiong, H., Rahal, S., Vanderluit, J., Slack, R.S., Zhang, Y., Guan, Y., Breyer, M.D., Hébert, R.L. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  26. The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Lolait, S.J., Stewart, L.Q., Jessop, D.S., Young, W.S., O'Carroll, A.M. Endocrinology (2007) [Pubmed]
  27. Radioimmunologic detection and measurement of nonapeptides in the pineal gland. Fernstrom, J.D., Fisher, L.A., Cusack, B.M., Gillis, M.A. Endocrinology (1980) [Pubmed]
  28. Cell cycle-dependent coupling of the vasopressin V1a receptor to different G proteins. Abel, A., Wittau, N., Wieland, T., Schultz, G., Kalkbrenner, F. J. Biol. Chem. (2000) [Pubmed]
  29. Genetic analysis of the hypothalamic corticotropin-releasing factor system. Garlow, S.J., Boone, E., Li, W., Owens, M.J., Nemeroff, C.B. Endocrinology (2005) [Pubmed]
  30. Corticotropin-releasing hormone expression is the major target for glucocorticoid feedback-control at the hypothalamic level. Kretz, O., Reichardt, H.M., Schütz, G., Bock, R. Brain Res. (1999) [Pubmed]
  31. Arginine vasopressin inhibition of cyclin D1 gene expression blocks the cell cycle and cell proliferation in the mouse Y1 adrenocortical tumor cell line. Schwindt, T.T., Forti, F.L., Juliano, M.A., Juliano, L., Armelin, H.A. Biochemistry (2003) [Pubmed]
  32. Arginine vasopressin induces the expression of c-fos in the mouse septum and hippocampus. Giri, P.R., Dave, J.R., Tabakoff, B., Hoffman, P.L. Brain Res. Mol. Brain Res. (1990) [Pubmed]
  33. Hypertonicity regulates the aquaporin-2 promoter independently of arginine vasopressin. Kasono, K., Saito, T., Saito, T., Tamemoto, H., Yanagidate, C., Uchida, S., Kawakami, M., Sasaki, S., Ishikawa, S.E. Nephrol. Dial. Transplant. (2005) [Pubmed]
  34. Endothelin 1 increases cell calcium in mouse collecting tubule cells. Naruse, M., Uchida, S., Ogata, E., Kurokawa, K. Am. J. Physiol. (1991) [Pubmed]
  35. The effects of nitric oxide on magnocellular neurons could involve multiple indirect cyclic GMP-dependent pathways. Vacher, C.M., Hardin-Pouzet, H., Steinbusch, H.W., Calas, A., De Vente, J. Eur. J. Neurosci. (2003) [Pubmed]
  36. Expression of the arginine vasopressin gene in response to salt loading in oxytocin gene knockout mice. Ozaki, Y., Nomura, M., Saito, J., Luedke, C.E., Muglia, L.J., Matsumoto, T., Ogawa, S., Ueta, Y., Pfaff, D.W. J. Neuroendocrinol. (2004) [Pubmed]
  37. Effects of nonapeptide antagonists on oxytocin- and arginine-vasopressin-induced analgesia in mice. Caldwell, J.D., Mason, G.A., Stanley, D.A., Jerdack, G., Hruby, V.J., Hill, P., Prange, A.J., Pedersen, C.A. Regul. Pept. (1987) [Pubmed]
  38. Changes of vasopressin- and oxytocin-immunoreactive neurons after hypophysectomy in young and old mice. Kawamoto, K., Kawashima, S. Exp. Gerontol. (1985) [Pubmed]
WikiGenes - Universities