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Gene Review

TFAP2B  -  transcription factor AP-2 beta (activating...

Homo sapiens

Synonyms: AP-2B, AP2-B, AP2-beta, Activating enhancer-binding protein 2-beta, Transcription factor AP-2-beta
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Disease relevance of TFAP2B


High impact information on TFAP2B


Biological context of TFAP2B


Anatomical context of TFAP2B


Associations of TFAP2B with chemical compounds

  • Furthermore, constitutive AP-2B expression in PA-1 cells causes a retinoic acid-resistant phenotype, anchorage-independent growth in soft agar, and tumorigenicity in nude mice, in a fashion similar to transformation of these cells by oncogenes [4].
  • However, small sample sizes from 1999-2003 for fish <1000 g limited the power of this comparison in Char and Amituk Lakes. In Resolute Lake char, manganese, strontium and zinc showed consistent decreases from 1997 or 1999 to 2003 while nickel generally increased over the 6 year period [11].
  • Predominance of Char Sorption over Substrate Concentration and Soil pH in Influencing Biodegradation of Benzonitrile [12].
  • Mean (+/- SD) Qm's (mg cholesterol adsorbed/gm dry sorbent) decreased in the order Super Char highly activated charcoal (277 +/- 121), Norit USP XX charcoal (33 +/- 10), Acta-Char charcoal (26 +/- 4), Mallinckrodt USP charcoal (26 +/- 10), Norit A charcoal (22 +/- 4) and cholestyramine (0) [13].

Other interactions of TFAP2B

  • Therefore, inhibition of AP-2 activity by the protein AP-2B may require an additional factor or modification supplied by nuclear extracts [4].
  • Expression of AP-2B in SB-2 cells augmented their tumorigenicity in nude mice, and upregulated MMP-2 expression and activity [14].
  • Gel shift and supershift experiments supported binding of p53, junB and heterodimers of AP2alpha/AP2gamma or AP2beta/AP2gamma to this sequence [15].

Analytical, diagnostic and therapeutic context of TFAP2B


  1. Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. Satoda, M., Zhao, F., Diaz, G.A., Burn, J., Goodship, J., Davidson, H.R., Pierpont, M.E., Gelb, B.D. Nat. Genet. (2000) [Pubmed]
  2. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. Maeda, S., Tsukada, S., Kanazawa, A., Sekine, A., Tsunoda, T., Koya, D., Maegawa, H., Kashiwagi, A., Babazono, T., Matsuda, M., Tanaka, Y., Fujioka, T., Hirose, H., Eguchi, T., Ohno, Y., Groves, C.J., Hattersley, A.T., Hitman, G.A., Walker, M., Kaku, K., Iwamoto, Y., Kawamori, R., Kikkawa, R., Kamatani, N., McCarthy, M.I., Nakamura, Y. J. Hum. Genet. (2005) [Pubmed]
  3. Intronic Polymorphisms within TFAP2B Regulate Transcriptional Activity and Affect Adipocytokine Gene Expression in Differentiated Adipocytes. Tsukada, S., Tanaka, Y., Maegawa, H., Kashiwagi, A., Kawamori, R., Maeda, S. Mol. Endocrinol. (2006) [Pubmed]
  4. An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. Buettner, R., Kannan, P., Imhof, A., Bauer, R., Yim, S.O., Glockshuber, R., Van Dyke, M.W., Tainsky, M.A. Mol. Cell. Biol. (1993) [Pubmed]
  5. Dominant-negative transcription factor AP-2 augments SB-2 melanoma tumor growth in vivo. Gershenwald, J.E., Sumner, W., Calderone, T., Wang, Z., Huang, S., Bar-Eli, M. Oncogene (2001) [Pubmed]
  6. Syndromic patent ductus arteriosus: evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder. Mani, A., Radhakrishnan, J., Farhi, A., Carew, K.S., Warnes, C.A., Nelson-Williams, C., Day, R.W., Pober, B., State, M.W., Lifton, R.P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder. Damberg, M., Westberg, L., Berggård, C., Landen, M., Sundblad, C., Eriksson, O., Naessén, T., Ekman, A., Eriksson, E. Neurosci. Lett. (2005) [Pubmed]
  8. Molecular determinants of atrial and ventricular septal defects and patent ductus arteriosus. Vaughan, C.J., Basson, C.T. Am. J. Med. Genet. (2000) [Pubmed]
  9. Cloning and characterization of a second AP-2 transcription factor: AP-2 beta. Moser, M., Imhof, A., Pscherer, A., Bauer, R., Amselgruber, W., Sinowatz, F., Hofstädter, F., Schüle, R., Buettner, R. Development (1995) [Pubmed]
  10. Pigmented peripheral nerve sheath tumor of the oral cavity with expression of AP-2 beta and c-RET: a case report. Dammer, R., Stavenow, J., Held, P., Schröder, J., Niederdellmann, H., Hofstädter, F., Buettner, R. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1997) [Pubmed]
  11. Spatial and temporal trends of mercury and other metals in landlocked char from lakes in the Canadian Arctic archipelago. Muir, D., Wang, X., Bright, D., Lockhart, L., Köck, G. Sci. Total Environ. (2005) [Pubmed]
  12. Predominance of Char Sorption over Substrate Concentration and Soil pH in Influencing Biodegradation of Benzonitrile. Zhang, P., Sheng, G., Feng, Y., Miller, D.M. Biodegradation (2006) [Pubmed]
  13. Correlative studies of the hypocholesterolemic effect of a highly activated charcoal. Tishler, P.V., Winston, S.H., Bell, S.M. Methods and findings in experimental and clinical pharmacology. (1987) [Pubmed]
  14. Gene regulation in melanoma progression by the AP-2 transcription factor. Bar-Eli, M. Pigment Cell Res. (2001) [Pubmed]
  15. KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells. Marreiros, A., Dudgeon, K., Dao, V., Grimm, M.O., Czolij, R., Crossley, M., Jackson, P. Oncogene (2005) [Pubmed]
  16. Absent lacrimal ducts, distichiasis, dysmorphic features, and brachydactyly: a case report. Holder-Espinasse, M., de Blois, M.C., Faivre, L., Romana, S., Uteza, Y., Munnich, A., Lyonnet, S., Cormier-Daire, V., Amiel, J. Clin. Dysmorphol. (2001) [Pubmed]
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