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Gene Review

PPP1R13L  -  protein phosphatase 1, regulatory subunit...

Homo sapiens

Synonyms: IASPP, Inhibitor of ASPP protein, NFkB-interacting protein 1, NKIP1, PPP1R13B-like protein, ...
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Disease relevance of PPP1R13L


Psychiatry related information on PPP1R13L

  • The RAI polymorphism showed a trend towards risk reduction for both adenomas (OR of 0.70, 95% CI 0.49-1.01) and carcinomas (OR of 0.49, 95% CI 0.21-1.13) among women, although not significant [3].

High impact information on PPP1R13L

  • Inhibition of iASPP could provide an important new strategy for treating tumors expressing wild-type p53 [4].
  • RAI gene encodes a protein with homology to the C-terminal region of 53BP2 containing four consecutive ankyrin repeats and an Src homology 3 domain [5].
  • The effect upon subcellular localization of the longer N-terminus of iASPP means that this new, longer form of the molecule may be subject to greater regulation and provides another layer in the control of p53-induced apoptosis [6].
  • One third of patients with SS (15 of 45) but no S patients met a recently described criterion for RAI (total cortisol increment after tetracosactrin < or = 248 nmol/liter) [7].
  • Recently, low total cortisol increments after tetracosactrin have been associated with increased mortality and hemodynamic responsiveness to exogenous hydrocortisone in septic shock (SS), a phenomenon termed by some investigators as relative adrenal insufficiency (RAI) [7].

Chemical compound and disease context of PPP1R13L

  • Here we describe the applications of the thiocyanate elution method in the determination of the relative affinity index (RAI) of phage antibodies (Phabs) [8].
  • Recent studies have proven that low doses of hydrocortisone and fludrocortisone can significantly reduce mortality in patients with relative adrenal insufficiency (RAI) without increasing adverse events [9].

Biological context of PPP1R13L


Anatomical context of PPP1R13L

  • However, iASPP gene expression in AL cells was not associated with gender, age, initial white blood cell count or p53 type, but was associated with CD34 expression [2].
  • In our experience with dosimetry, we have observed that this empiric dosing strategy often results in administered RAI activities exceeding the MTA safety limit of 200 cGy (rads) to the blood or bone marrow in many patients with metastatic thyroid cancer [13].

Associations of PPP1R13L with chemical compounds

  • 4E-BP1 has been shown to associate with the scaffold protein raptor through its TOS and RAIP motifs to be recognized by mTOR [11].
  • The use of proton nuclear magnetic resonance spectrometry (1H NMR) for monitoring the reaction of epoxides with butylamine and predictive capabilities of the relative alkylation index (RAI) for skin sensitization by epoxides [14].
  • Patients with presumed RAI were more likely to be on phenylephrine or vasopressin infusions and treated with activated protein C and had a longer intensive care unit stay but no difference in intensive care unit survival [15].
  • The chloramphenicol acetyltransferase activity assay in Rcho-1 cells revealed that cotransfection of RAI expression vector resulted in decreased activity of the rat GLUT1 promoter but not in that of a mutated rat GLUT1 promoter lacking the Sp1 binding site [16].

Physical interactions of PPP1R13L


Other interactions of PPP1R13L


Analytical, diagnostic and therapeutic context of PPP1R13L


  1. RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions. Takada, N., Sanda, T., Okamoto, H., Yang, J.P., Asamitsu, K., Sarol, L., Kimura, G., Uranishi, H., Tetsuka, T., Okamoto, T. J. Virol. (2002) [Pubmed]
  2. The expression of iASPP in acute leukemias. Zhang, X., Wang, M., Zhou, C., Chen, S., Wang, J. Leuk. Res. (2005) [Pubmed]
  3. Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. Skjelbred, C.F., Saebø, M., Nexø, B.A., Wallin, H., Hansteen, I.L., Vogel, U., Kure, E.H. BMC Cancer (2006) [Pubmed]
  4. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Bergamaschi, D., Samuels, Y., O'Neil, N.J., Trigiante, G., Crook, T., Hsieh, J.K., O'Connor, D.J., Zhong, S., Campargue, I., Tomlinson, M.L., Kuwabara, P.E., Lu, X. Nat. Genet. (2003) [Pubmed]
  5. Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor. Yang, J.P., Hori, M., Sanda, T., Okamoto, T. J. Biol. Chem. (1999) [Pubmed]
  6. The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization. Slee, E.A., Gillotin, S., Bergamaschi, D., Royer, C., Llanos, S., Ali, S., Jin, B., Trigiante, G., Lu, X. Oncogene (2004) [Pubmed]
  7. Septic shock and sepsis: a comparison of total and free plasma cortisol levels. Ho, J.T., Al-Musalhi, H., Chapman, M.J., Quach, T., Thomas, P.D., Bagley, C.J., Lewis, J.G., Torpy, D.J. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  8. Thiocyanate elution measurement of relative affinity of phage antibodies. Wang, G., Wang, Y., Li, C.Y., Gao, T.W., Liu, Y.F. Sheng Wu Gong Cheng Xue Bao (2004) [Pubmed]
  9. Relative adrenal insufficiency among trauma patients in a community hospital. Beeman, B.R., Veverka, T.J., Lambert, P., Boysen, D.M. Current surgery. (2005) [Pubmed]
  10. Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. Laska, M.J., Nexø, B.A., Vistisen, K., Poulsen, H.E., Loft, S., Vogel, U. Cancer Lett. (2005) [Pubmed]
  11. Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size. Eguchi, S., Tokunaga, C., Hidayat, S., Oshiro, N., Yoshino, K., Kikkawa, U., Yonezawa, K. Genes Cells (2006) [Pubmed]
  12. Mechanism based structure-activity relationships for skin sensitisation--the carbonyl group domain. Roberts, D.W., Patlewicz, G. SAR and QSAR in environmental research. (2002) [Pubmed]
  13. Empiric radioactive iodine dosing regimens frequently exceed maximum tolerated activity levels in elderly patients with thyroid cancer. Tuttle, R.M., Leboeuf, R., Robbins, R.J., Qualey, R., Pentlow, K., Larson, S.M., Chan, C.Y. J. Nucl. Med. (2006) [Pubmed]
  14. The use of proton nuclear magnetic resonance spectrometry (1H NMR) for monitoring the reaction of epoxides with butylamine and predictive capabilities of the relative alkylation index (RAI) for skin sensitization by epoxides. Roberts, D.W. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  15. Relative adrenal insufficiency in patients with septic shock; a close look to practice patterns. Elsouri, N., Bander, J., Guzman, J.A. Journal of critical care. (2006) [Pubmed]
  16. Involvement of RelA-associated inhibitor in regulation of trophoblast differentiation via interaction with transcriptional factor specificity protein-1. Minekawa, R., Sakata, M., Okamoto, Y., Hayashi, M., Isobe, A., Takeda, T., Yamamoto, T., Koyama, M., Ohmichi, M., Tasaka, K., Imai, K., Okamoto, T., Murata, Y. Endocrinology (2007) [Pubmed]
  17. The last two days of life of nursing home patients--a nationwide study on causes of death and burdensome symptoms in The Netherlands. Brandt, H.E., Ooms, M.E., Deliens, L., van der Wal, G., Ribbe, M.W. Palliative medicine. (2006) [Pubmed]
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