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Gene Review

MYCT1  -  myc target 1

Homo sapiens

Synonyms: FLJ21269, MTLC, MTMC1, Myc target in myeloid cells protein 1, Myc target protein 1
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Disease relevance of MYCT1


High impact information on MYCT1

  • Our findings point to a high regulatory and biological diversity among Myc-target genes [5].
  • A possible mechanism for MYC-mediated apoptosis was revealed by identification of the tumor necrosis factor receptor associated protein TRAP1 as a MYC target [6].
  • No significant differences were found between patients with (SMC) or without (CC/MTLC) persistent host-type hematopoiesis with respect to the duration of the leukemia-free interval, the overall survival, or the leukemia-free survival [7].
  • In the bone marrow, only donor-type cells were found in children with either CC (n = 8) or MTLC (n = 2), and a mixture of donor- and recipient-type cells was found in children with SMC (n = 7) [7].
  • In the peripheral blood, the children showed either stable mixed chimerism (SMC; ie, persistent host-type hematopoiesis; n = 14), (transient) mixed T-lymphoid chimerism (MTLC; n = 9), or complete chimerism (CC; n = 30) [7].

Biological context of MYCT1


Anatomical context of MYCT1


Associations of MYCT1 with chemical compounds


Regulatory relationships of MYCT1


Other interactions of MYCT1

  • Investigations of this emerging NTD-based network may reveal how c-Myc is regulated and how it affects cell fate, as well as providing tools to distinguish the physiological roles of various Myc target genes [17].
  • Thus, the TIP60 HAT complex is recruited to MYC-target genes and, probably with other other HATs, contributes to histone acetylation in response to mitogenic signals [18].

Analytical, diagnostic and therapeutic context of MYCT1


  1. Expression of MTLC gene in gastric carcinoma. Qiu, G.B., Gong, L.G., Hao, D.M., Zhen, Z.H., Sun, K.L. World J. Gastroenterol. (2003) [Pubmed]
  2. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. Koshiji, M., Kageyama, Y., Pete, E.A., Horikawa, I., Barrett, J.C., Huang, L.E. EMBO J. (2004) [Pubmed]
  3. Increased expression of a Myc target gene Mina53 in human colon cancer. Teye, K., Tsuneoka, M., Arima, N., Koda, Y., Nakamura, Y., Ueta, Y., Shirouzu, K., Kimura, H. Am. J. Pathol. (2004) [Pubmed]
  4. Unsaturated fatty acids bind Myc-Max transcription factor and inhibit Myc-Max-DNA complex formation. Chung, S., Park, S., Yang, C.H. Cancer Lett. (2002) [Pubmed]
  5. Genomic targets of the human c-Myc protein. Fernandez, P.C., Frank, S.R., Wang, L., Schroeder, M., Liu, S., Greene, J., Cocito, A., Amati, B. Genes Dev. (2003) [Pubmed]
  6. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Coller, H.A., Grandori, C., Tamayo, P., Colbert, T., Lander, E.S., Eisenman, R.N., Golub, T.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Persistence of host-type hematopoiesis after allogeneic bone marrow transplantation for leukemia is significantly related to the recipient's age and/or the conditioning regimen, but it is not associated with an increased risk of relapse. van Leeuwen, J.E., van Tol, M.J., Joosten, A.M., Wijnen, J.T., Verweij, P.J., Khan, P.M., Vossen, J.M. Blood (1994) [Pubmed]
  8. A novel myc target gene, mina53, that is involved in cell proliferation. Tsuneoka, M., Koda, Y., Soejima, M., Teye, K., Kimura, H. J. Biol. Chem. (2002) [Pubmed]
  9. Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Mao, D.Y., Watson, J.D., Yan, P.S., Barsyte-Lovejoy, D., Khosravi, F., Wong, W.W., Farnham, P.J., Huang, T.H., Penn, L.Z. Curr. Biol. (2003) [Pubmed]
  10. Cell cycle: on target with Myc. Zörnig, M., Evan, G.I. Curr. Biol. (1996) [Pubmed]
  11. Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line. Schlosser, I., Hölzel, M., Hoffmann, R., Burtscher, H., Kohlhuber, F., Schuhmacher, M., Chapman, R., Weidle, U.H., Eick, D. Oncogene (2005) [Pubmed]
  12. The Mad and Myc basic domains are functionally equivalent. Nikiforov, M.A., Popov, N., Kotenko, I., Henriksson, M., Cole, M.D. J. Biol. Chem. (2003) [Pubmed]
  13. The transcriptional program of a human B cell line in response to Myc. Schuhmacher, M., Kohlhuber, F., Hölzel, M., Kaiser, C., Burtscher, H., Jarsch, M., Bornkamm, G.W., Laux, G., Polack, A., Weidle, U.H., Eick, D. Nucleic Acids Res. (2001) [Pubmed]
  14. Generation of chronic myelogenous leukemia-specific T cells in cytokine-modified autologous mixed lymphocyte/tumor cell cultures. Müller, L., Provenzani, C., Pawelec, G. J. Immunother. (2001) [Pubmed]
  15. Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells. Medh, R.D., Wang, A., Zhou, F., Thompson, E.B. Oncogene (2001) [Pubmed]
  16. Structural and thermodynamical characterization of the complete p21 gene product of Max. Naud, J.F., McDuff, F.O., Sauvé, S., Montagne, M., Webb, B.A., Smith, S.P., Chabot, B., Lavigne, P. Biochemistry (2005) [Pubmed]
  17. New Myc-interacting proteins: a second Myc network emerges. Sakamuro, D., Prendergast, G.C. Oncogene (1999) [Pubmed]
  18. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. Frank, S.R., Parisi, T., Taubert, S., Fernandez, P., Fuchs, M., Chan, H.M., Livingston, D.M., Amati, B. EMBO Rep. (2003) [Pubmed]
  19. A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Nikiforov, M.A., Chandriani, S., O'Connell, B., Petrenko, O., Kotenko, I., Beavis, A., Sedivy, J.M., Cole, M.D. Mol. Cell. Biol. (2002) [Pubmed]
  20. Identification of genes that are regulated transcriptionally by Myc in childhood tumors. Raetz, E.A., Kim, M.K., Moos, P., Carlson, M., Bruggers, C., Hooper, D.K., Foot, L., Liu, T., Seeger, R., Carroll, W.L. Cancer (2003) [Pubmed]
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