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Gene Review

Marcksl1  -  MARCKS-like 1

Rattus norvegicus

Synonyms: Brain protein F52, F52, MARCKS-like protein 1, MARCKS-related protein, Mac-MARCKS, ...
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High impact information on Marcksl1


Biological context of Marcksl1

  • Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells [1].
  • These results are consistent with a role for MacMARCKS in integrating Ca(2+)-calmodulin and protein kinase C-dependent signals in the regulation of neurosecretion [1].
  • In the present study, we examined MARCKS and MRP gene expression in the postnatal (P) rat brain (1, 7, 14, 21, and 90 days after birth) by using quantitative in situ hybridization [2].
  • Upon cotransfection with SERT, MacMARCKS caused a reduction in the maximal rate of [(3)H]serotonin uptake and reduced its down-regulation elicited by activation of PKC [3].

Anatomical context of Marcksl1


Associations of Marcksl1 with chemical compounds

  • Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C [3].

Other interactions of Marcksl1

  • MacMARCKS (also known as myristoylated alanine-rich C kinase substrate (MARCKS)-related protein) is a member of the MARCKS family of protein kinase C substrates, which binds Ca2+/calmodulin in a phosphorylation-dependent manner [1].


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