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Chemical Compound Review

Classic     ethyl2-[(4-chloro-6-methoxy- pyrimidin-2...

Synonyms: AG-H-73315, DPX-F 6025, CHEMBL1231791, HSDB 6850, AC-18022, ...
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Disease relevance of Classic


Psychiatry related information on Classic

  • BACKGROUND: Classic GSS is characterized by an early age at onset, prominent cerebellar signs with a slowly evolving dementia, and a neuropathology including multifocal PrP-positive plaques and variable but usually modest spongiform change [6].
  • In a study of the MMPI personality types of hospitalized men and women alcoholics, the Neurotic and Classic types had the characteristics of reactive alcoholism, and the Psychopathic, Schizoform A and Schizoform B types had the characteristics of essential alcoholism [7].
  • Folie à deux - a mad family. (Classic Text No.35, with introduction by G.E. Berrios) [8].
  • Seignot's paper on the treatment of Tourette's syndrome with haloperidol. Classic Text No. 31 [9].

High impact information on Classic

  • Here we report the 2.8 A resolution crystal structure of yeast AHAS in complex with a sulfonylurea herbicide, chlorimuron ethyl [10].
  • One hundred fifty-seven sera from 120 patients with SLE were examined for classic (c) and perinuclear (p) pattern ANCA by indirect immunofluorescence [11].
  • Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma [12].
  • We assume that the differential expression levels of some of these genes reflect, analogous to SCLC, the different biological and clinical properties of Classic and Variant MCC phenotypes [12].
  • BACKGROUND: Classic fat balance studies detect fat malabsorption but do not discriminate between the potential causes of malabsorption, such as impaired intestinal lipolysis or reduced uptake of fatty acids [13].

Chemical compound and disease context of Classic


Biological context of Classic


Anatomical context of Classic


Associations of Classic with other chemical compounds


Gene context of Classic

  • RESULTS: Classic plasma markers of endothelial injury, tPA and sTM significantly elevated in SARS patients in comparison to controls [t-PA: 1.48 +/- 0.16 nmol/L versus 0.25 +/- 0.03 nmol/L (P<0.0001), and sTM: 0.26 +/- 0.06 nmol/L versus 0.14 +/- 0.02 nmol/L (P<0.05)] [32].
  • In humans, deficiency of galactose-1-phosphate uridyltransferase (GALT) can lead a metabolic disorder Classic Galactosemia [33].
  • In these conditions, we classified and quantified three pathological structures associated to the neuritic degenerative process: 1) Amyloid-beta deposits (AbetaDs), 2) Classic neuritic plaques (NPs), and 3) Dystrophic neurites clusters (DNCs) lacking amyloid-beta deposits [34].
  • The classic (C) MCs of normal salivary glands stained by IMP with antibodies to cytokeratin and S100 protein and stained by IMF with the same antibodies and with antibodies to vimentin and actin [35].
  • Molecular Analysis of the CLCNKB Gene in Japanese Patients with Classic Bartter Syndrome [36].

Analytical, diagnostic and therapeutic context of Classic


  1. Classic Kaposi's sarcoma associated with human herpesvirus 8 infection in a 13-year-old male: a case report. Landau, H.J., Poiesz, B.J., Dube, S., Bogart, J.A., Weiner, L.B., Souid, A.K. Clin. Cancer Res. (2001) [Pubmed]
  2. The search for the genetic lesion in Ashkenazi Jews with Classic Tay-Sachs disease. Myerowitz, R. Adv. Genet. (2001) [Pubmed]
  3. Distal acquired demyelinating symmetric neuropathy. Katz, J.S., Saperstein, D.S., Gronseth, G., Amato, A.A., Barohn, R.J. Neurology (2000) [Pubmed]
  4. Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America. Monroe, M.C., Morzunov, S.P., Johnson, A.M., Bowen, M.D., Artsob, H., Yates, T., Peters, C.J., Rollin, P.E., Ksiazek, T.G., Nichol, S.T. Emerging Infect. Dis. (1999) [Pubmed]
  5. Why are strokes related to hypertension? Classic studies and hypotheses revisited. Dickinson, C.J. J. Hypertens. (2001) [Pubmed]
  6. A three-sister sibship of Gerstmann-Sträussler-Scheinker disease with a CJD phenotype. Majtényi, C., Brown, P., Cervenáková, L., Goldfarb, L.G., Tateishi, J. Neurology (2000) [Pubmed]
  7. Personality typology of men and women alcoholics in relation to etiology and prognosis. Conley, J.J., Prioleau, L.A. J. Stud. Alcohol (1983) [Pubmed]
  8. Folie à deux - a mad family. (Classic Text No.35, with introduction by G.E. Berrios). Ireland, W.W. History of psychiatry. (1998) [Pubmed]
  9. Seignot's paper on the treatment of Tourette's syndrome with haloperidol. Classic Text No. 31. Rickards, H., Hartley, N., Robertson, M.M. History of psychiatry. (1997) [Pubmed]
  10. Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. Pang, S.S., Guddat, L.W., Duggleby, R.G. J. Biol. Chem. (2003) [Pubmed]
  11. Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. Prevalence, specificities, and clinical significance. Schnabel, A., Csernok, E., Isenberg, D.A., Mrowka, C., Gross, W.L. Arthritis Rheum. (1995) [Pubmed]
  12. Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma. Van Gele, M., Boyle, G.M., Cook, A.L., Vandesompele, J., Boonefaes, T., Rottiers, P., Van Roy, N., De Paepe, A., Parsons, P.G., Leonard, J.H., Speleman, F. Oncogene (2004) [Pubmed]
  13. Detection of impaired intestinal absorption of long-chain fatty acids: validation studies of a novel test in a rat model of fat malabsorption. Kalivianakis, M., Minich, D.M., Havinga, R., Kuipers, F., Stellaard, F., Vonk, R.J., Verkade, H.J. Am. J. Clin. Nutr. (2000) [Pubmed]
  14. History of epilepsy in Chinese traditional medicine. Lai, C.W., Lai, Y.H. Epilepsia (1991) [Pubmed]
  15. Single and joint toxicity of chlorimuron-ethyl, cadmium, and copper acting on wheat Triticum aestivum. Wang, M., Zhou, Q. Ecotoxicol. Environ. Saf. (2005) [Pubmed]
  16. The Classic: amputation and adriamycin in primary osteosarcoma. 1974. Cortes, E.P., Holland, J.F., Wang, J.J., Sinks, L.F., Blom, J., Senn, H., Bank, A., Glidewell, O. Clin. Orthop. Relat. Res. (2005) [Pubmed]
  17. Clinical performance of two opaque, tinted soft contact lenses. Gauthier, C.A., Grant, T., Holden, B.A. Journal of the American Optometric Association. (1992) [Pubmed]
  18. Mutagenesis of Escherichia coli acetohydroxyacid synthase isoenzyme II and characterization of three herbicide-insensitive forms. Hill, C.M., Duggleby, R.G. Biochem. J. (1998) [Pubmed]
  19. Differentiation-Specific Factors Modulate Epidermal CYP1-4 Gene Expression in Human Skin in Response to Retinoic Acid and Classic Aryl Hydrocarbon Receptor Ligands. Du, L., Neis, M.M., Ladd, P.A., Keeney, D.S. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  20. Divergent patterns of allelic alterations in premalignant laryngeal lesions indicate differences in the impact of morphological grading characteristics. Kleist, B., Poetsch, M. Oncology (2004) [Pubmed]
  21. Testicular seminomas are aneuploid tumors. Hittmair, A., Rogatsch, H., Feichtinger, H., Hobisch, A., Mikuz, G. Lab. Invest. (1995) [Pubmed]
  22. The influence of dose on the long-term control of Classic (non-AIDS associated) Kaposi's sarcoma by radiotherapy. Cooper, J.S. Int. J. Radiat. Oncol. Biol. Phys. (1988) [Pubmed]
  23. Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Strissel, K.J., Rinehart, W.B., Fini, M.E. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  24. Low T Cell Responses to Human Herpesvirus 8 in Patients with AIDS-Related and Classic Kaposi Sarcoma. Guihot, A., Dupin, N., Marcelin, A.G., Gorin, I., Bedin, A.S., Bossi, P., Galicier, L., Oksenhendler, E., Autran, B., Carcelain, G. J. Infect. Dis. (2006) [Pubmed]
  25. Popliteal artery entrapment syndrome: arteriographic findings and thrombolytic therapy. Ring, D.H., Haines, G.A., Miller, D.L. Journal of vascular and interventional radiology : JVIR. (1999) [Pubmed]
  26. The modified Norwood procedure for hypoplastic left heart syndrome: early to intermediate results of 120 patients with particular reference to aortic arch repair. Ishino, K., Stümper, O., De Giovanni, J.J., Silove, E.D., Wright, J.G., Sethia, B., Brawn, W.J., de Leval, M. J. Thorac. Cardiovasc. Surg. (1999) [Pubmed]
  27. Urinary tract stone disease. Classic studies. Scott, R. Urology (1975) [Pubmed]
  28. Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study. Hoppin, J.A., Umbach, D.M., London, S.J., Lynch, C.F., Alavanja, M.C., Sandler, D.P. Am. J. Epidemiol. (2006) [Pubmed]
  29. Predicted values of propofol EC50 and sevoflurane concentration for insertion of laryngeal mask Classic and ProSeal. Kodaka, M., Okamoto, Y., Koyama, K., Miyao, H. British journal of anaesthesia. (2004) [Pubmed]
  30. High concentration potassium permanganate eliminates protein and particle contamination of the reusable Classic laryngeal mask airway. Laupu, W., Laupau, W., Brimacombe, J., Richards, E., Keller, C. Anaesthesia. (2006) [Pubmed]
  31. Nitrous oxide diffusion into the cuffs of disposable laryngeal mask airways. Maino, P., Dullenkopf, A., Bernet, V., Weiss, M. Anaesthesia. (2005) [Pubmed]
  32. Elevated plasma tissue-type plasminogen activator (t-PA) and soluble thrombomodulin in patients suffering from severe acute respiratory syndrome (SARS) as a possible index for prognosis and treatment strategy. Liu, Z.H., Wei, R., Wu, Y.P., Lisman, T., Wang, Z.X., Han, J.J., Ren, D.L., Chen, B., Xia, Z.L., Chen, B., Zhu, Z., Zhang, Y., Cui, X., Hu, H.T., de Groot, P.G., Xu, W.B. Biomed. Environ. Sci. (2005) [Pubmed]
  33. Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model. Slepak, T., Tang, M., Addo, F., Lai, K. Mol. Genet. Metab. (2005) [Pubmed]
  34. Coexistence of reactive plasticity and neurodegeneration in Alzheimer diseased brains. Guevara, J., Dilhuydy, H., Espinosa, B., Delacourte, A., Quirion, R., Mena, R., Joanette, Y., Zenteno, E., Robitaille, Y. Histol. Histopathol. (2004) [Pubmed]
  35. Myoepithelial cells in salivary gland tumors. An immunohistochemical study. Kahn, H.J., Baumal, R., Marks, A., Dardick, I., van Nostrand, A.W. Arch. Pathol. Lab. Med. (1985) [Pubmed]
  36. Molecular Analysis of the CLCNKB Gene in Japanese Patients with Classic Bartter Syndrome. Tajima, T., Nawate, M., Takahashi, Y., Mizoguchi, Y., Sugihara, S., Yoshimoto, M., Murakami, M., Adachi, M., Tachibana, K., Mochizuki, H., Fujieda, K. Endocr. J. (2006) [Pubmed]
  37. Genetic and environmental contributions to the development of alcohol dependence in male twins. Liu, I.C., Blacker, D.L., Xu, R., Fitzmaurice, G., Lyons, M.J., Tsuang, M.T. Arch. Gen. Psychiatry (2004) [Pubmed]
  38. Morbidity of modified prophylactic inguinal lymphadenectomy for squamous cell carcinoma of the penis. Coblentz, T.R., Theodorescu, D. J. Urol. (2002) [Pubmed]
  39. Open donor, laparoscopic donor and hand assisted laparoscopic donor nephrectomy: a comparison of outcomes. Ruiz-Deya, G., Cheng, S., Palmer, E., Thomas, R., Slakey, D. J. Urol. (2001) [Pubmed]
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