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Gene Review

Tfap4  -  transcription factor AP4

Mus musculus

Synonyms: AI642933, AP-4, D930048N17Rik, Tcfap4, bHLHc41
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Disease relevance of Tcfap4


High impact information on Tcfap4

  • Here we report the isolation of the enhancer binding factor AP-4, which recognizes a motif in this domain [2].
  • The deduced amino acid sequence reveals that AP-4 is a helix-loop-helix (HLH) protein [3].
  • However, unlike other HLH proteins, AP-4 also contains two additional protein dimerization motifs consisting of leucine repeat elements LR1 and LR2 [3].
  • Enhancer binding protein AP-4 is a transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence, CAGCTG [3].
  • Like other members of this family, the AP-4 HLH motif and the adjacent basic domain are necessary and sufficient to confer site-specific DNA binding [3].

Chemical compound and disease context of Tcfap4


Biological context of Tcfap4


Anatomical context of Tcfap4

  • The heterotetrameric adaptor protein (AP) complexes AP-1, AP-2, AP-3, and AP-4 play key roles in transport vesicle formation and cargo sorting in post-Golgi trafficking pathways [9].
  • Electrophoretic mobility shift assays (EMSA) demonstrated that binding of AP-4- and AP-5-like proteins of mouse L and HeLa cells to the GT-II motif occurs in a mutually exclusive manner [10].

Associations of Tcfap4 with chemical compounds


Regulatory relationships of Tcfap4

  • In contrast, both the expression and activation of Casp-9 were inhibited in the antisense AP-4 transfectants [1].

Other interactions of Tcfap4

  • Western blot analysis revealed that the expression of Bcl-xL, Bax, and Apaf-1 was not affected in cells transfected with sense or antisense AP-4 genes [1].

Analytical, diagnostic and therapeutic context of Tcfap4

  • Here, we report the molecular cloning and characterization of human AP-4 cDNAs [3].
  • Chromatin immunoprecipitation experiments reveal that the interacting Igkappa gene cis-acting sequences are associated with AP-4, E47, and p65NF-kappaB, potential protein candidates that may be responsible for initiating and/or maintaining the formation of these higher-order complexes [12].
  • Sequence analysis revealed several AP-1, AP-4, myo-D, GATA, and SP-1 sequences [13].


  1. Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. Tsujimoto, K., Ono, T., Sato, M., Nishida, T., Oguma, T., Tadakuma, T. J. Biol. Chem. (2005) [Pubmed]
  2. Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Mermod, N., Williams, T.J., Tjian, R. Nature (1988) [Pubmed]
  3. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Hu, Y.F., Lüscher, B., Admon, A., Mermod, N., Tjian, R. Genes Dev. (1990) [Pubmed]
  4. The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain. Quitschke, W.W., Goldgaber, D. J. Biol. Chem. (1992) [Pubmed]
  5. Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. Xiu, Y., Nakamura, K., Abe, M., Li, N., Wen, X.S., Jiang, Y., Zhang, D., Tsurui, H., Matsuoka, S., Hamano, Y., Fujii, H., Ono, M., Takai, T., Shimokawa, T., Ra, C., Shirai, T., Hirose, S. J. Immunol. (2002) [Pubmed]
  6. The upstream region of the Rpe65 gene confers retinal pigment epithelium-specific expression in vivo and in vitro and contains critical octamer and E-box binding sites. Boulanger, A., Liu, S., Henningsgaard, A.A., Yu, S., Redmond, T.M. J. Biol. Chem. (2000) [Pubmed]
  7. Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer. Alam, J., Camhi, S., Choi, A.M. J. Biol. Chem. (1995) [Pubmed]
  8. Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue-specific initiation of transcription in the macrophage and the uterus. Katsuyama, M., Sugimoto, Y., Okano, K., Segi, E., Ikegami, R., Negishi, M., Ichikawa, A. Biochem. J. (1998) [Pubmed]
  9. Clathrin adaptor AP-2 is essential for early embryonal development. Mitsunari, T., Nakatsu, F., Shioda, N., Love, P.E., Grinberg, A., Bonifacino, J.S., Ohno, H. Mol. Cell. Biol. (2005) [Pubmed]
  10. AP-4- and AP-5-like proteins from mouse L cells are trans-activators and bind to the GT-II region of SV40 early TRE in a mutually exclusive manner. Hou, Y.T., Coleman, T.A., Kopchick, J.J. Gene (1995) [Pubmed]
  11. AP-4, a novel protein complex related to clathrin adaptors. Dell'Angelica, E.C., Mullins, C., Bonifacino, J.S. J. Biol. Chem. (1999) [Pubmed]
  12. Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobases. Liu, Z., Garrard, W.T. Mol. Cell. Biol. (2005) [Pubmed]
  13. Structure and functional regulation of the CD38 promoter. Sun, L., Iqbal, J., Zaidi, S., Zhu, L.L., Zhang, X., Peng, Y., Moonga, B.S., Zaidi, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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