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Gene Review

Apaf1  -  apoptotic peptidase activating factor 1

Mus musculus

Synonyms: 6230400I06Rik, APAF-1, Apaf-1, Apaf1l, Apoptotic protease-activating factor 1, ...
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Disease relevance of Apaf1


High impact information on Apaf1


Biological context of Apaf1


Anatomical context of Apaf1


Associations of Apaf1 with chemical compounds


Regulatory relationships of Apaf1


Other interactions of Apaf1


Analytical, diagnostic and therapeutic context of Apaf1


  1. Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis. Guo, Z., Yikang, S., Yoshida, H., Mak, T.W., Zacksenhaus, E. Cancer Res. (2001) [Pubmed]
  2. Localization of Apaf1 gene expression in the early development of the mouse by means of in situ reverse transcriptase-polymerase chain reaction. Müller, M., Berger, J., Gersdorff, N., Cecconi, F., Herken, R., Quondamatteo, F. Dev. Dyn. (2005) [Pubmed]
  3. An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease. Mochizuki, H., Hayakawa, H., Migita, M., Shibata, M., Tanaka, R., Suzuki, A., Shimo-Nakanishi, Y., Urabe, T., Yamada, M., Tamayose, K., Shimada, T., Miura, M., Mizuno, Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Adult Apaf-1-deficient mice exhibit male infertility. Honarpour, N., Du, C., Richardson, J.A., Hammer, R.E., Wang, X., Herz, J. Dev. Biol. (2000) [Pubmed]
  5. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Hao, Z., Duncan, G.S., Chang, C.C., Elia, A., Fang, M., Wakeham, A., Okada, H., Calzascia, T., Jang, Y., You-Ten, A., Yeh, W.C., Ohashi, P., Wang, X., Mak, T.W. Cell (2005) [Pubmed]
  6. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Yoshida, H., Kong, Y.Y., Yoshida, R., Elia, A.J., Hakem, A., Hakem, R., Penninger, J.M., Mak, T.W. Cell (1998) [Pubmed]
  7. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Marsden, V.S., O'Connor, L., O'Reilly, L.A., Silke, J., Metcalf, D., Ekert, P.G., Huang, D.C., Cecconi, F., Kuida, K., Tomaselli, K.J., Roy, S., Nicholson, D.W., Vaux, D.L., Bouillet, P., Adams, J.M., Strasser, A. Nature (2002) [Pubmed]
  8. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Joza, N., Susin, S.A., Daugas, E., Stanford, W.L., Cho, S.K., Li, C.Y., Sasaki, T., Elia, A.J., Cheng, H.Y., Ravagnan, L., Ferri, K.F., Zamzami, N., Wakeham, A., Hakem, R., Yoshida, H., Kong, Y.Y., Mak, T.W., Zúñiga-Pflücker, J.C., Kroemer, G., Penninger, J.M. Nature (2001) [Pubmed]
  9. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. Cregan, S.P., Fortin, A., MacLaurin, J.G., Callaghan, S.M., Cecconi, F., Yu, S.W., Dawson, T.M., Dawson, V.L., Park, D.S., Kroemer, G., Slack, R.S. J. Cell Biol. (2002) [Pubmed]
  10. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. Fortin, A., Cregan, S.P., MacLaurin, J.G., Kushwaha, N., Hickman, E.S., Thompson, C.S., Hakim, A., Albert, P.R., Cecconi, F., Helin, K., Park, D.S., Slack, R.S. J. Cell Biol. (2001) [Pubmed]
  11. Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth. Cecconi, F., Roth, K.A., Dolgov, O., Munarriz, E., Anokhin, K., Gruss, P., Salminen, M. Development (2004) [Pubmed]
  12. Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific. Ho, A.T., Li, Q.H., Hakem, R., Mak, T.W., Zacksenhaus, E. EMBO J. (2004) [Pubmed]
  13. The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes. Hara, H., Takeda, A., Takeuchi, M., Wakeham, A.C., Itié, A., Sasaki, M., Mak, T.W., Yoshimura, A., Nomoto, K., Yoshida, H. J. Immunol. (2002) [Pubmed]
  14. Cisplatin-induced in vivo differentiation of human embryonal carcinoma. Mizutani, Y., Sato, N., Kawauchi, A., Nonomura, N., Fukushima, M., Miki, T. BJU international. (2002) [Pubmed]
  15. Caspase regulation of genotoxin-induced neural precursor cell death. D'Sa, C., Klocke, B.J., Cecconi, F., Lindsten, T., Thompson, C.B., Korsmeyer, S.J., Flavell, R.A., Roth, K.A. J. Neurosci. Res. (2003) [Pubmed]
  16. Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline. Tomicic, M.T., Christmann, M., Fabian, K., Kaina, B. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  17. ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1. Shiraishi, H., Okamoto, H., Yoshimura, A., Yoshida, H. J. Cell. Sci. (2006) [Pubmed]
  18. Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1. Steel, R., Doherty, J.P., Buzzard, K., Clemons, N., Hawkins, C.J., Anderson, R.L. J. Biol. Chem. (2004) [Pubmed]
  19. Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development. Donovan, M., Cotter, T.G. Cell Death Differ. (2002) [Pubmed]
  20. Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1. Honarpour, N., Tabuchi, K., Stark, J.M., Hammer, R.E., Südhof, T.C., Parada, L.F., Wang, X., Richardson, J.A., Herz, J. Neuroscience (2001) [Pubmed]
  21. Localization, regulation and possible consequences of apoptotic protease-activating factor-1 (Apaf-1) expression in granulosa cells of the mouse ovary. Robles, R., Tao, X.J., Trbovich, A.M., Maravel, D.V., Nahum, R., Perez, G.I., Tilly, K.I., Tilly, J.L. Endocrinology (1999) [Pubmed]
  22. Expression of apoptosis-related factors in muscles infected with Trichinella spiralis. Boonmars, T., Wu, Z., Nagano, I., Takahashi, Y. Parasitology (2004) [Pubmed]
  23. Apaf-1 deficiency and neural tube closure defects are found in fog mice. Honarpour, N., Gilbert, S.L., Lahn, B.T., Wang, X., Herz, J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  24. Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. Wallace, D.M., Donovan, M., Cotter, T.G. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
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