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Gene Review

Grip1  -  glutamate receptor interacting protein 1

Rattus norvegicus

Synonyms: AMPA receptor-interacting protein GRIP1, GRIP-1, Glutamate receptor-interacting protein 1
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Disease relevance of Grip1


High impact information on Grip1


Biological context of Grip1


Anatomical context of Grip1

  • A clonal cell line prepared from immortalized GRP cells, termed GRIP-1, was also shown to retain the properties of a glial-restricted tripotential precursor [8].
  • ErbB1 receptor ligands attenuate the expression of synaptic scaffolding proteins, GRIP1 and SAP97, in developing neocortex [9].
  • Constitutive uterine mRNA expression of switch protein for antagonist (SPA), SRC-1, GRIP1, RAC3, RIP140, and p300 mRNAs was observed in control uteri, and treatment with ER ligands did not alter coactivator mRNA levels [10].

Associations of Grip1 with chemical compounds

  • NMDA receptors interact via their NR2 subunits with PSD-95/SAP90 family proteins, whereas AMPA receptors bind via their GluR2/3 subunits to glutamate receptor-interacting protein (GRIP), AMPA receptor-binding protein (ABP), and protein interacting with C kinase 1 (PICK1) [5].
  • GRIP1 PDZ7 contains a closed carboxyl group-binding pocket and a narrow alphaB/betaB-groove that is not likely to bind to classical PDZ ligands [1].
  • The interaction between GRIP1 PDZ7 and a Ras guanine nucleotide exchange factor, GRASP-1, regulates synaptic distribution of AMPA receptors [1].
  • Differential cellular and subcellular localization of ampa receptor-binding protein and glutamate receptor-interacting protein [11].
  • 2. Grip strength and biochemical measurements, i.e. serum creatine phosphokinase (CPK) activity and creatine urinary excretion rate, together with histological studies, were performed in resting animals during a period of 14 days of PYR administration in a dose producing 20-30% whole blood acetylcholinesterase inhibition [12].

Physical interactions of Grip1


Other interactions of Grip1

  • Decline in SAP97 and GRIP1 levels was associated with increased abundance of lower molecular weight bands, suggesting degradation of these proteins [14].
  • Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: implications for synaptic plasticity [15].
  • Using in situ hybridization we have examined the neuroanatomical distribution of the messenger RNAs (mRNAs) for two functionally distinct splice variants of Steroid Receptor Coactivator 1 (SRC-1/NCoA-1) and of Steroid Receptor Coactivator 2 (SRC-2/NCoA-2/GRIP-1/TIF-2) [16].
  • Such coactivators include three members of the 160 kDa proteins (p160s): SRC-1, TIF2/GRIP1, and p/CIP/RAC3/ACTR/AIB1/TRAM-1 [17].

Analytical, diagnostic and therapeutic context of Grip1


  1. PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area. Feng, W., Fan, J.S., Jiang, M., Shi, Y.W., Zhang, M. J. Biol. Chem. (2002) [Pubmed]
  2. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Dong, H., O'Brien, R.J., Fung, E.T., Lanahan, A.A., Worley, P.F., Huganir, R.L. Nature (1997) [Pubmed]
  3. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Srivastava, S., Osten, P., Vilim, F.S., Khatri, L., Inman, G., States, B., Daly, C., DeSouza, S., Abagyan, R., Valtschanoff, J.G., Weinberg, R.J., Ziff, E.B. Neuron (1998) [Pubmed]
  4. Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Kim, P.M., Aizawa, H., Kim, P.S., Huang, A.S., Wickramasinghe, S.R., Kashani, A.H., Barrow, R.K., Huganir, R.L., Ghosh, A., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo. Wyszynski, M., Valtschanoff, J.G., Naisbitt, S., Dunah, A.W., Kim, E., Standaert, D.G., Weinberg, R., Sheng, M. J. Neurosci. (1999) [Pubmed]
  6. A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain. Charych, E.I., Yu, W., Li, R., Serwanski, D.R., Miralles, C.P., Li, X., Yang, B.Y., Pinal, N., Walikonis, R., De Blas, A.L. J. Biol. Chem. (2004) [Pubmed]
  7. Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons. Matsuda, S., Launey, T., Mikawa, S., Hirai, H. EMBO J. (2000) [Pubmed]
  8. Isolation of a glial-restricted tripotential cell line from embryonic spinal cord cultures. Wu, Y.Y., Mujtaba, T., Han, S.S., Fischer, I., Rao, M.S. Glia (2002) [Pubmed]
  9. ErbB1 receptor ligands attenuate the expression of synaptic scaffolding proteins, GRIP1 and SAP97, in developing neocortex. Yokomaku, D., Jourdi, H., Kakita, A., Nagano, T., Takahashi, H., Takei, N., Nawa, H. Neuroscience (2005) [Pubmed]
  10. Expression of estrogen receptor coactivators in the rat uterus. Nephew, K.P., Ray, S., Hlaing, M., Ahluwalia, A., Wu, S.D., Long, X., Hyder, S.M., Bigsby, R.M. Biol. Reprod. (2000) [Pubmed]
  11. Differential cellular and subcellular localization of ampa receptor-binding protein and glutamate receptor-interacting protein. Burette, A., Khatri, L., Wyszynski, M., Sheng, M., Ziff, E.B., Weinberg, R.J. J. Neurosci. (2001) [Pubmed]
  12. Study of muscular effects of short-term pyridostigmine treatment in resting and exercising rats. Hubert, M., Lison, D. Human & experimental toxicology. (1995) [Pubmed]
  13. GRIP1 in GABAergic synapses. Li, R.W., Serwanski, D.R., Miralles, C.P., Li, X., Charych, E., Riquelme, R., Huganir, R.L., de Blas, A.L. J. Comp. Neurol. (2005) [Pubmed]
  14. Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors induces calpain-mediated PSD-95/Dlg/ZO-1 protein degradation and AMPA receptor down-regulation in cultured hippocampal slices. Jourdi, H., Lu, X., Yanagihara, T., Lauterborn, J.C., Bi, X., Gall, C.M., Baudry, M. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  15. Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: implications for synaptic plasticity. Lu, X., Wyszynski, M., Sheng, M., Baudry, M. J. Neurochem. (2001) [Pubmed]
  16. Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary. Meijer, O.C., Steenbergen, P.J., De Kloet, E.R. Endocrinology (2000) [Pubmed]
  17. Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. Igarashi-Migitaka, J., Takeshita, A., Koibuchi, N., Yamada, S., Ohtani-Kaneko, R., Hirata, K. Eur. J. Endocrinol. (2005) [Pubmed]
  18. Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2. Steiner, P., Alberi, S., Kulangara, K., Yersin, A., Sarria, J.C., Regulier, E., Kasas, S., Dietler, G., Muller, D., Catsicas, S., Hirling, H. EMBO J. (2005) [Pubmed]
  19. Crystallization and preliminary X-ray crystallographic studies of the sixth PDZ domain of glutamate-receptor interacting protein 1 (GRIP1) from Rattus norvegicus. Park, S.H., Im, Y.J., Rho, S.H., Lee, J.H., Yang, S., Kim, E., Eom, S.H. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
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