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Chemical Compound Review

S-nitrosoglutathione     (2S)-2-amino-4-[[(1S)-1...

Synonyms: GNSO, SNOG, gsno, CHEMBL63507, CCRIS 2095, ...
 
 
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Disease relevance of S-nitrosoglutathione

 

High impact information on S-nitrosoglutathione

 

Chemical compound and disease context of S-nitrosoglutathione

 

Biological context of S-nitrosoglutathione

 

Anatomical context of S-nitrosoglutathione

  • Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary [21].
  • Although S-nitrosoglutathione (GSNO), a slow releaser of NO, also inhibited the respiration of tumor cell mitochondria, its effect was significantly lower than that of NO [22].
  • Incubation of isolated rat hepatocytes with S-nitrosoglutathione monoethyl ester (EGSNO), a NO donor permeable through the cellular membrane, induced a dose-dependent inactivation of MAT that was reversed by removing the NO donor from the cell suspension [23].
  • To determine whether nitric oxide (NO) can modulate bradykinin (BK) signaling pathways, we treated endothelial cells with an NO donor, S-nitrosoglutathione (GSNO), to determine its effect(s) on G-proteins (Gi and Gq) that are coupled to the type II kinin (BK2) receptor [24].
  • Modulation of smooth muscle, L-type Ca(2+) channels (class C, Ca(V)1.2b) by thionitrite S-nitrosoglutathione (GSNO) was investigated in the human embryonic kidney 293 expression system at the level of whole-cell and single-channel currents [25].
 

Associations of S-nitrosoglutathione with other chemical compounds

 

Gene context of S-nitrosoglutathione

 

Analytical, diagnostic and therapeutic context of S-nitrosoglutathione

References

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  12. Hypersensitivity of ataxia-telangiectasia fibroblasts to a nitric oxide donor. Green, M.H., Marcovitch, A.J., Harcourt, S.A., Lowe, J.E., Green, I.C., Arlett, C.F. Free Radic. Biol. Med. (1997) [Pubmed]
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  14. Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis. Venketaraman, V., Dayaram, Y.K., Talaue, M.T., Connell, N.D. Infect. Immun. (2005) [Pubmed]
  15. Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. Shi, Y., Hutchins, W., Ogawa, H., Chang, C.C., Pritchard, K.A., Zhang, C., Khampang, P., Lazar, J., Jacob, H.J., Rafiee, P., Baker, J.E. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  16. Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states. Crawford, J.H., White, C.R., Patel, R.P. Blood (2003) [Pubmed]
  17. Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178. Wang, J., Fillebeen, C., Chen, G., Andriopoulos, B., Pantopoulos, K. Mol. Cell. Biol. (2006) [Pubmed]
  18. Neuroprotection by S-nitrosoglutathione of brain dopamine neurons from oxidative stress. Rauhala, P., Lin, A.M., Chiueh, C.C. FASEB J. (1998) [Pubmed]
  19. Cyclooxygenase-2: an essential regulator of NO-mediated apoptosis. von Knethen, A., Brüne, B. FASEB J. (1997) [Pubmed]
  20. S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels. Aracena, P., Sánchez, G., Donoso, P., Hamilton, S.L., Hidalgo, C. J. Biol. Chem. (2003) [Pubmed]
  21. Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary. Clancy, R.M., Levartovsky, D., Leszczynska-Piziak, J., Yegudin, J., Abramson, S.B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  22. Role of glutathione in nitric oxide-dependent regulation of energy metabolism in rat hepatoma cells. Nishikawa, M., Sato, E.F., Kashiba, M., Kuroki, T., Utsumi, K., Inoue, M. Hepatology (1998) [Pubmed]
  23. Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation. Ruiz, F., Corrales, F.J., Miqueo, C., Mato, J.M. Hepatology (1998) [Pubmed]
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  25. S-nitrosation controls gating and conductance of the alpha 1 subunit of class C L-type Ca(2+) channels. Poteser, M., Romanin, C., Schreibmayer, W., Mayer, B., Groschner, K. J. Biol. Chem. (2001) [Pubmed]
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  29. S-Nitrosocysteine increases palmitate turnover on Ha-Ras in NIH 3T3 cells. Baker, T.L., Booden, M.A., Buss, J.E. J. Biol. Chem. (2000) [Pubmed]
  30. Bcl-2 protects macrophages from nitric oxide-induced apoptosis. Messmer, U.K., Reed, U.K., Brüne, B. J. Biol. Chem. (1996) [Pubmed]
  31. Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo. Giustizieri, M.L., Albanesi, C., Scarponi, C., De Pità, O., Girolomoni, G. Am. J. Pathol. (2002) [Pubmed]
  32. S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Carvalho-Filho, M.A., Ueno, M., Hirabara, S.M., Seabra, A.B., Carvalheira, J.B., de Oliveira, M.G., Velloso, L.A., Curi, R., Saad, M.J. Diabetes (2005) [Pubmed]
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  35. Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty. Langford, E.J., Brown, A.S., Wainwright, R.J., de Belder, A.J., Thomas, M.R., Smith, R.E., Radomski, M.W., Martin, J.F., Moncada, S. Lancet (1994) [Pubmed]
  36. Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Schrammel, A., Pfeiffer, S., Schmidt, K., Koesling, D., Mayer, B. Mol. Pharmacol. (1998) [Pubmed]
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  38. A study of platelet activation during human cardiopulmonary bypass and the effect of S-nitrosoglutathione. Langford, E.J., Parfitt, A., de Belder, A.J., Marrinan, M.T., Martin, J.F. Thromb. Haemost. (1997) [Pubmed]
  39. Buried s-nitrosocysteine revealed in crystal structures of human thioredoxin(,). Weichsel, A., Brailey, J.L., Montfort, W.R. Biochemistry (2007) [Pubmed]
 
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