The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

S-nitrosoglutathione     (2S)-2-amino-4-[[(1S)-1...

Synonyms: GNSO, SNOG, gsno, CHEMBL63507, CCRIS 2095, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of S-nitrosoglutathione


High impact information on S-nitrosoglutathione


Chemical compound and disease context of S-nitrosoglutathione


Biological context of S-nitrosoglutathione


Anatomical context of S-nitrosoglutathione

  • Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary [21].
  • Although S-nitrosoglutathione (GSNO), a slow releaser of NO, also inhibited the respiration of tumor cell mitochondria, its effect was significantly lower than that of NO [22].
  • Incubation of isolated rat hepatocytes with S-nitrosoglutathione monoethyl ester (EGSNO), a NO donor permeable through the cellular membrane, induced a dose-dependent inactivation of MAT that was reversed by removing the NO donor from the cell suspension [23].
  • To determine whether nitric oxide (NO) can modulate bradykinin (BK) signaling pathways, we treated endothelial cells with an NO donor, S-nitrosoglutathione (GSNO), to determine its effect(s) on G-proteins (Gi and Gq) that are coupled to the type II kinin (BK2) receptor [24].
  • Modulation of smooth muscle, L-type Ca(2+) channels (class C, Ca(V)1.2b) by thionitrite S-nitrosoglutathione (GSNO) was investigated in the human embryonic kidney 293 expression system at the level of whole-cell and single-channel currents [25].

Associations of S-nitrosoglutathione with other chemical compounds


Gene context of S-nitrosoglutathione


Analytical, diagnostic and therapeutic context of S-nitrosoglutathione


  1. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., Stamler, J.S. Nature (2001) [Pubmed]
  2. Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model. De Groote, M.A., Granger, D., Xu, Y., Campbell, G., Prince, R., Fang, F.C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Preconditioning regulation of bcl-2 and p66shc by human NOS1 enhances tolerance to oxidative stress. Andoh, T., Lee, S.Y., Chiueh, C.C. FASEB J. (2000) [Pubmed]
  4. Flavohemoglobin detoxifies nitric oxide in aerobic, but not anaerobic, Escherichia coli. Evidence for a novel inducible anaerobic nitric oxide-scavenging activity. Gardner, A.M., Gardner, P.R. J. Biol. Chem. (2002) [Pubmed]
  5. Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo. Inoue, K., Akaike, T., Miyamoto, Y., Okamoto, T., Sawa, T., Otagiri, M., Suzuki, S., Yoshimura, T., Maeda, H. J. Biol. Chem. (1999) [Pubmed]
  6. Induction of platelet formation from megakaryocytoid cells by nitric oxide. Battinelli, E., Willoughby, S.R., Foxall, T., Valeri, C.R., Loscalzo, J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  7. Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates. St John, G., Brot, N., Ruan, J., Erdjument-Bromage, H., Tempst, P., Weissbach, H., Nathan, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury. Ma, X.L., Gao, F., Liu, G.L., Lopez, B.L., Christopher, T.A., Fukuto, J.M., Wink, D.A., Feelisch, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059. Mohr, S., McCormick, T.S., Lapetina, E.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers. Becker, K., Savvides, S.N., Keese, M., Schirmer, R.H., Karplus, P.A. Nat. Struct. Biol. (1998) [Pubmed]
  11. Transcriptional responses of Escherichia coli to S-nitrosoglutathione under defined chemostat conditions reveal major changes in methionine biosynthesis. Flatley, J., Barrett, J., Pullan, S.T., Hughes, M.N., Green, J., Poole, R.K. J. Biol. Chem. (2005) [Pubmed]
  12. Hypersensitivity of ataxia-telangiectasia fibroblasts to a nitric oxide donor. Green, M.H., Marcovitch, A.J., Harcourt, S.A., Lowe, J.E., Green, I.C., Arlett, C.F. Free Radic. Biol. Med. (1997) [Pubmed]
  13. U937 apoptotic cell death by nitric oxide: Bcl-2 downregulation and caspase activation. Brockhaus, F., Brüne, B. Exp. Cell Res. (1998) [Pubmed]
  14. Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis. Venketaraman, V., Dayaram, Y.K., Talaue, M.T., Connell, N.D. Infect. Immun. (2005) [Pubmed]
  15. Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. Shi, Y., Hutchins, W., Ogawa, H., Chang, C.C., Pritchard, K.A., Zhang, C., Khampang, P., Lazar, J., Jacob, H.J., Rafiee, P., Baker, J.E. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  16. Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states. Crawford, J.H., White, C.R., Patel, R.P. Blood (2003) [Pubmed]
  17. Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178. Wang, J., Fillebeen, C., Chen, G., Andriopoulos, B., Pantopoulos, K. Mol. Cell. Biol. (2006) [Pubmed]
  18. Neuroprotection by S-nitrosoglutathione of brain dopamine neurons from oxidative stress. Rauhala, P., Lin, A.M., Chiueh, C.C. FASEB J. (1998) [Pubmed]
  19. Cyclooxygenase-2: an essential regulator of NO-mediated apoptosis. von Knethen, A., Brüne, B. FASEB J. (1997) [Pubmed]
  20. S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels. Aracena, P., Sánchez, G., Donoso, P., Hamilton, S.L., Hidalgo, C. J. Biol. Chem. (2003) [Pubmed]
  21. Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary. Clancy, R.M., Levartovsky, D., Leszczynska-Piziak, J., Yegudin, J., Abramson, S.B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  22. Role of glutathione in nitric oxide-dependent regulation of energy metabolism in rat hepatoma cells. Nishikawa, M., Sato, E.F., Kashiba, M., Kuroki, T., Utsumi, K., Inoue, M. Hepatology (1998) [Pubmed]
  23. Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation. Ruiz, F., Corrales, F.J., Miqueo, C., Mato, J.M. Hepatology (1998) [Pubmed]
  24. Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric oxide. Miyamoto, A., Laufs, U., Pardo, C., Liao, J.K. J. Biol. Chem. (1997) [Pubmed]
  25. S-nitrosation controls gating and conductance of the alpha 1 subunit of class C L-type Ca(2+) channels. Poteser, M., Romanin, C., Schreibmayer, W., Mayer, B., Groschner, K. J. Biol. Chem. (2001) [Pubmed]
  26. Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production. Gilchrist, M., McCauley, S.D., Befus, A.D. Blood (2004) [Pubmed]
  27. Nitric oxide modulates a late step of exocytosis. Machado, J.D., Segura, F., Brioso, M.A., Borges, R. J. Biol. Chem. (2000) [Pubmed]
  28. Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion. Forsythe, P., Befus, A.D. J. Immunol. (2003) [Pubmed]
  29. S-Nitrosocysteine increases palmitate turnover on Ha-Ras in NIH 3T3 cells. Baker, T.L., Booden, M.A., Buss, J.E. J. Biol. Chem. (2000) [Pubmed]
  30. Bcl-2 protects macrophages from nitric oxide-induced apoptosis. Messmer, U.K., Reed, U.K., Brüne, B. J. Biol. Chem. (1996) [Pubmed]
  31. Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo. Giustizieri, M.L., Albanesi, C., Scarponi, C., De Pità, O., Girolomoni, G. Am. J. Pathol. (2002) [Pubmed]
  32. S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Carvalho-Filho, M.A., Ueno, M., Hirabara, S.M., Seabra, A.B., Carvalheira, J.B., de Oliveira, M.G., Velloso, L.A., Curi, R., Saad, M.J. Diabetes (2005) [Pubmed]
  33. Nitric oxide regulation of human peripheral blood mononuclear cells: critical time dependence and selectivity for cytokine versus chemokine expression. Macphail, S.E., Gibney, C.A., Brooks, B.M., Booth, C.G., Flanagan, B.F., Coleman, J.W. J. Immunol. (2003) [Pubmed]
  34. Resolution, detection, and characterization of redox conformers of human HSF1. Manalo, D.J., Liu, A.Y. J. Biol. Chem. (2001) [Pubmed]
  35. Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty. Langford, E.J., Brown, A.S., Wainwright, R.J., de Belder, A.J., Thomas, M.R., Smith, R.E., Radomski, M.W., Martin, J.F., Moncada, S. Lancet (1994) [Pubmed]
  36. Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Schrammel, A., Pfeiffer, S., Schmidt, K., Koesling, D., Mayer, B. Mol. Pharmacol. (1998) [Pubmed]
  37. S-nitrosoglutathione in rat cerebellum: identification and quantification by liquid chromatography-mass spectrometry. Kluge, I., Gutteck-Amsler, U., Zollinger, M., Do, K.Q. J. Neurochem. (1997) [Pubmed]
  38. A study of platelet activation during human cardiopulmonary bypass and the effect of S-nitrosoglutathione. Langford, E.J., Parfitt, A., de Belder, A.J., Marrinan, M.T., Martin, J.F. Thromb. Haemost. (1997) [Pubmed]
  39. Buried s-nitrosocysteine revealed in crystal structures of human thioredoxin(,). Weichsel, A., Brailey, J.L., Montfort, W.R. Biochemistry (2007) [Pubmed]
WikiGenes - Universities