Gene Review:
CDC34 - SCF E2 ubiquitin-protein ligase catalytic...
Saccharomyces cerevisiae S288c
Synonyms:
Cell division control protein 34, D4211, DNA6, E3 ubiquitin ligase complex SCF subunit CDC34, UBC3, ...
- Ubiquitin conjugation by the yeast RAD6 and CDC34 gene products. Comparison to their putative rabbit homologs, E2(20K) AND E2(32K). Haas, A.L., Reback, P.B., Chau, V. J. Biol. Chem. (1991)
- Investigation of intracellular factors involved in methylmercury toxicity. Naganuma, A., Furuchi, T., Miura, N., Hwang, G.W., Kuge, S. Tohoku J. Exp. Med. (2002)
- ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Babbitt, S.E., Kiss, A., Deffenbaugh, A.E., Chang, Y.H., Bailly, E., Erdjument-Bromage, H., Tempst, P., Buranda, T., Sklar, L.A., Baumler, J., Gogol, E., Skowyra, D. Cell (2005)
- Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. Deffenbaugh, A.E., Scaglione, K.M., Zhang, L., Moore, J.M., Buranda, T., Sklar, L.A., Skowyra, D. Cell (2003)
- Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4. Kaiser, P., Flick, K., Wittenberg, C., Reed, S.I. Cell (2000)
- The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Schwob, E., Böhm, T., Mendenhall, M.D., Nasmyth, K. Cell (1994)
- G2 cyclins are required for the degradation of G1 cyclins in yeast. Blondel, M., Mann, C. Nature (1996)
- A chimeric ubiquitin conjugating enzyme that combines the cell cycle properties of CDC34 (UBC3) and the DNA repair properties of RAD6 (UBC2): implications for the structure, function and evolution of the E2s. Silver, E.T., Gwozd, T.J., Ptak, C., Goebl, M., Ellison, M.J. EMBO J. (1992)
- Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Yoon, H.J., Carbon, J. Mol. Cell. Biol. (1995)
- The Cdc34/SCF Ubiquitination Complex Mediates Saccharomyces cerevisiae Cell Wall Integrity. Varelas, X., Stuart, D., Ellison, M.J., Ptak, C. Genetics (2006)
- Identification of a portable determinant of cell cycle function within the carboxyl-terminal domain of the yeast CDC34 (UBC3) ubiquitin conjugating (E2) enzyme. Kolman, C.J., Toth, J., Gonda, D.K. EMBO J. (1992)
- Overexpression of the ubiquitin-conjugating enzyme Cdc34 confers resistance to methylmercury in Saccharomyces cerevisiae. Furuchi, T., Hwang, G.W., Naganuma, A. Mol. Pharmacol. (2002)
- Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domains. Liu, Y., Mathias, N., Steussy, C.N., Goebl, M.G. Mol. Cell. Biol. (1995)
- Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity. Varelas, X., Ptak, C., Ellison, M.J. Mol. Cell. Biol. (2003)
- The bacterially expressed yeast CDC34 gene product can undergo autoubiquitination to form a multiubiquitin chain-linked protein. Banerjee, A., Gregori, L., Xu, Y., Chau, V. J. Biol. Chem. (1993)
- Increased ubiquitin expression suppresses the cell cycle defect associated with the yeast ubiquitin conjugating enzyme, CDC34 (UBC3). Evidence for a noncovalent interaction between CDC34 and ubiquitin. Prendergast, J.A., Ptak, C., Arnason, T.G., Ellison, M.J. J. Biol. Chem. (1995)
- Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast. Patton, E.E., Willems, A.R., Sa, D., Kuras, L., Thomas, D., Craig, K.L., Tyers, M. Genes Dev. (1998)
- The Ubc3 (Cdc34) ubiquitin-conjugating enzyme is ubiquitinated and phosphorylated in vivo. Goebl, M.G., Goetsch, L., Byers, B. Mol. Cell. Biol. (1994)
- Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro. Kus, B.M., Caldon, C.E., Andorn-Broza, R., Edwards, A.M. Proteins (2004)
- Identification of a positive regulator of the cell cycle ubiquitin-conjugating enzyme Cdc34 (Ubc3). Prendergast, J.A., Ptak, C., Kornitzer, D., Steussy, C.N., Hodgins, R., Goebl, M., Ellison, M.J. Mol. Cell. Biol. (1996)
- Novel CDC34 (UBC3) ubiquitin-conjugating enzyme mutants obtained by charge-to-alanine scanning mutagenesis. Pitluk, Z.W., McDonough, M., Sangan, P., Gonda, D.K. Mol. Cell. Biol. (1995)
- Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Henchoz, S., Chi, Y., Catarin, B., Herskowitz, I., Deshaies, R.J., Peter, M. Genes Dev. (1997)
- Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. Kaiser, P., Sia, R.A., Bardes, E.G., Lew, D.J., Reed, S.I. Genes Dev. (1998)
- Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. Mathias, N., Johnson, S.L., Winey, M., Adams, A.E., Goetsch, L., Pringle, J.R., Byers, B., Goebl, M.G. Mol. Cell. Biol. (1996)
- SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Verma, R., Feldman, R.M., Deshaies, R.J. Mol. Biol. Cell (1997)
- An essential domain within Cdc34p is required for binding to a complex containing Cdc4p and Cdc53p in Saccharomyces cerevisiae. Mathias, N., Steussy, C.N., Goebl, M.G. J. Biol. Chem. (1998)
- CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. Semplici, F., Meggio, F., Pinna, L.A., Oliviero, S. Oncogene (2002)