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Gene Review

SOR1  -  L-iditol 2-dehydrogenase SOR1

Saccharomyces cerevisiae S288c

Synonyms: J2395, L-iditol 2-dehydrogenase 1, SDH1, Sorbitol dehydrogenase 1, YJR159W
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High impact information on SOR1


Biological context of SOR1

  • Yeast transformants containing the cloned gene carried on a multicopy plasmid express high levels of SDH1 only when grown on sorbitol, suggesting that the cloned gene contains both regulatory and coding sequences [5].
  • The SDH1 structural gene was isolated from a lambda gt11 yeast genomic library using an antibody to a 40-kDa protein induced in yeast cells growing in medium containing sorbitol [5].
  • Homozygous mdh and sdh1 diploids are unable to sporulate [6].
  • The amino acid sequence of a large segment of the N-terminal part of a liver sorbitol dehydrogenase is now determined and shown to be strictly homologous with the long alcohol dehydrogenases [7].
  • Proline and glycine residues suggest largely similar conformations between N-terminal parts of sorbitol dehydrogenase and "long" alcohol dehydrogenases, cysteine and histidine residues suggest a conserved zinc atom at the active site, and other residues correlate with structures of special importance [7].

Associations of SOR1 with chemical compounds


Analytical, diagnostic and therapeutic context of SOR1


  1. Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis. Wagner, S., Bernhardt, A., Leuendorf, J.E., Drewke, C., Lytovchenko, A., Mujahed, N., Gurgui, C., Frommer, W.B., Leistner, E., Fernie, A.R., Hellmann, H. Plant Cell (2006) [Pubmed]
  2. Molecular aspects of functional differences between alcohol and sorbitol dehydrogenases. Eklund, H., Horjales, E., Jörnvall, H., Brändén, C.I., Jeffery, J. Biochemistry (1985) [Pubmed]
  3. Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase. Richard, P., Toivari, M.H., Penttilä, M. FEBS Lett. (1999) [Pubmed]
  4. Construction of a sorbitol-based vector for expression of heterologous proteins in Saccharomyces cerevisiae. McGonigal, T., Bodelle, P., Schopp, C., Sarthy, A.V. Appl. Environ. Microbiol. (1998) [Pubmed]
  5. Cloning and sequence determination of the gene encoding sorbitol dehydrogenase from Saccharomyces cerevisiae. Sarthy, A.V., Schopp, C., Idler, K.B. Gene (1994) [Pubmed]
  6. Isolation and characterization of yeast mutants defective in intermediary carbon metabolism and in carbon catabolite derepression. Ciriacy, M. Mol. Gen. Genet. (1977) [Pubmed]
  7. Alcohol and polyol dehydrogenases. Jörnvall, H., Carlquist, M., Jeffery, J. Pharmacol. Biochem. Behav. (1983) [Pubmed]
  8. Dual relationships of xylitol and alcohol dehydrogenases in families of two protein types. Persson, B., Hallborn, J., Walfridsson, M., Hahn-Hägerdal, B., Keränen, S., Penttilä, M., Jörnvall, H. FEBS Lett. (1993) [Pubmed]
  9. Properties of sorbitol dehydrogenase and characterization of a reactive cysteine residue reveal unexpected similarities to alcohol dehydrogenases. Jeffery, J., Cummins, L., Carlquist, M., Jörnvall, H. Eur. J. Biochem. (1981) [Pubmed]
  10. Affinity labelling of sorbitol dehydrogenase from sheep liver with alpha-bromo-beta-(5-imidazolyl)propionic acid. Reiersen, H., Sletten, K., McKinley-McKee, J.S. Eur. J. Biochem. (1993) [Pubmed]
  11. Extensive variations and basic features in the alcohol dehydrogenase-sorbitol dehydrogenase family. Jörnvall, H., von Bahr-Lindström, H., Jeffery, J. Eur. J. Biochem. (1984) [Pubmed]
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