The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SGT1  -  Sgt1p

Saccharomyces cerevisiae S288c

Synonyms: Protein SGT1, Suppressor of G2 allele of SKP1, YOR057W, YOR29-08
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SGT1


High impact information on SGT1

  • We have identified SGT1 as a dosage suppressor of skp1-4, a mutation causing defects in yeast kinetochore function [2].
  • Sgt1p physically associates with Skp1p in vivo and in vitro [2].
  • Sgt1p is required for assembling the yeast kinetochore complex, CBF3, via activation of Ctf13p [2].
  • RAR1 and its interacting partner SGT1 play a central role in plant disease resistance triggered by a number of resistance (R) proteins [3].
  • Our findings show that silencing SGT1 affects diverse types of disease resistance in plants and support the idea that R protein-mediated and nonhost resistance may involve similar mechanisms [4].

Biological context of SGT1


Anatomical context of SGT1


Associations of SGT1 with chemical compounds


Physical interactions of SGT1

  • We have found that Sgt1 interacts with Hsp90 in yeast [13].
  • Analyses of the dimerization of Sgt1 deletion proteins showed that the Skp1-binding domain (amino acids 1-211) contains the Sgt1 homodimerization domain [14].

Other interactions of SGT1


  1. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. Kordes, E., Savelyeva, L., Schwab, M., Rommelaere, J., Jauniaux, J.C., Cziepluch, C. Genomics (1998) [Pubmed]
  2. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Kitagawa, K., Skowyra, D., Elledge, S.J., Harper, J.W., Hieter, P. Mol. Cell (1999) [Pubmed]
  3. HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Takahashi, A., Casais, C., Ichimura, K., Shirasu, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants. Peart, J.R., Lu, R., Sadanandom, A., Malcuit, I., Moffett, P., Brice, D.C., Schauser, L., Jaggard, D.A., Xiao, S., Coleman, M.J., Dow, M., Jones, J.D., Shirasu, K., Baulcombe, D.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. The interaction between Sgt1p and Skp1p is regulated by HSP90 chaperones and is required for proper CBF3 assembly. Lingelbach, L.B., Kaplan, K.B. Mol. Cell. Biol. (2004) [Pubmed]
  6. The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K., Schulze-Lefert, P. Science (2002) [Pubmed]
  7. The tomato resistance protein Bs4 is a predicted non-nuclear TIR-NB-LRR protein that mediates defense responses to severely truncated derivatives of AvrBs4 and overexpressed AvrBs3. Schornack, S., Ballvora, A., Gürlebeck, D., Peart, J., Baulcombe, D., Ganal, M., Baker, B., Bonas, U., Lahaye, T. Plant J. (2004) [Pubmed]
  8. The primary in vivo steroidal alkaloid glucosyltransferase from potato. McCue, K.F., Allen, P.V., Shepherd, L.V., Blake, A., Whitworth, J., Maccree, M.M., Rockhold, D.R., Stewart, D., Davies, H.V., Belknap, W.R. Phytochemistry (2006) [Pubmed]
  9. Sgt1 is required for human kinetochore assembly. Steensgaard, P., Garrè, M., Muradore, I., Transidico, P., Nigg, E.A., Kitagawa, K., Earnshaw, W.C., Faretta, M., Musacchio, A. EMBO Rep. (2004) [Pubmed]
  10. The expression and function of Sgt1 protein in eukaryotic cells. Spiechowicz, M., Filipek, A. Acta neurobiologiae experimentalis. (2005) [Pubmed]
  11. Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Dubacq, C., Guerois, R., Courbeyrette, R., Kitagawa, K., Mann, C. Eukaryotic Cell (2002) [Pubmed]
  12. Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation. Schadick, K., Fourcade, H.M., Boumenot, P., Seitz, J.J., Morrell, J.L., Chang, L., Gould, K.L., Partridge, J.F., Allshire, R.C., Kitagawa, K., Hieter, P., Hoffman, C.S. Eukaryotic Cell (2002) [Pubmed]
  13. Sgt1 associates with Hsp90: an initial step of assembly of the core kinetochore complex. Bansal, P.K., Abdulle, R., Kitagawa, K. Mol. Cell. Biol. (2004) [Pubmed]
  14. Sgt1 dimerization is required for yeast kinetochore assembly. Bansal, P.K., Nourse, A., Abdulle, R., Kitagawa, K. J. Biol. Chem. (2009) [Pubmed]
WikiGenes - Universities