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Gene Review

PFK26  -  Pfk26p

Saccharomyces cerevisiae S288c

Synonyms: 6-phosphofructo-2-kinase 1, 6PF-2-K 1, Phosphofructokinase 2 I, YIL107C
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Disease relevance of PFK26


High impact information on PFK26


Biological context of PFK26


Anatomical context of PFK26


Associations of PFK26 with chemical compounds


Enzymatic interactions of PFK26


Regulatory relationships of PFK26


Other interactions of PFK26


Analytical, diagnostic and therapeutic context of PFK26


  1. Regulation of rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Role of the NH2-terminal region. Kurland, I.J., Li, L., Lange, A.J., Correia, J.J., el-Maghrabi, M.R., Pilkis, S.J. J. Biol. Chem. (1993) [Pubmed]
  2. Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Bazan, J.F., Fletterick, R.J., Pilkis, S.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. High osmolarity glycerol (HOG) pathway-induced phosphorylation and activation of 6-phosphofructo-2-kinase are essential for glycerol accumulation and yeast cell proliferation under hyperosmotic stress. Dihazi, H., Kessler, R., Eschrich, K. J. Biol. Chem. (2004) [Pubmed]
  4. Complete amino acid sequence of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Lively, M.O., el-Maghrabi, M.R., Pilkis, J., D'Angelo, G., Colosia, A.D., Ciavola, J.A., Fraser, B.A., Pilkis, S.J. J. Biol. Chem. (1988) [Pubmed]
  5. Mechanism of stimulation of endogenous fermentation in yeast by carbonyl cyanide m-chlorophenylhydrazone. Noshiro, A., Purwin, C., Laux, M., Nicolay, K., Scheffers, W.A., Holzer, H. J. Biol. Chem. (1987) [Pubmed]
  6. Cloning of a second gene encoding 5-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate. Boles, E., Göhlmann, H.W., Zimmermann, F.K. Mol. Microbiol. (1996) [Pubmed]
  7. Mutant studies of phosphofructo-2-kinases do not reveal an essential role of fructose-2,6-bisphosphate in the regulation of carbon fluxes in yeast cells. Müller, S., Zimmermann, F.K., Boles, E. Microbiology (Reading, Engl.) (1997) [Pubmed]
  8. Kinetics of 6-phosphofructo-2-kinase from Saccharomyces cerevisiae: inhibition of the enzyme by ATP. Bedri, A., Kretschmer, M., Schellenberger, W., Hofmann, E. Biomed. Biochim. Acta (1989) [Pubmed]
  9. Phosphorylation and inactivation of yeast 6-phosphofructo-2-kinase contribute to the regulation of glycolysis under hypotonic stress. Dihazi, H., Kessler, R., Eschrich, K. Biochemistry (2001) [Pubmed]
  10. The yeast FBP26 gene codes for a fructose-2,6-bisphosphatase. Paravicini, G., Kretschmer, M. Biochemistry (1992) [Pubmed]
  11. Yeast 6-phosphofructo-2-kinase: sequence and mutant. Kretschmer, M., Fraenkel, D.G. Biochemistry (1991) [Pubmed]
  12. Glucose-induced stimulation of the Ras-cAMP pathway in yeast leads to multiple phosphorylations and activation of 6-phosphofructo-2-kinase. Dihazi, H., Kessler, R., Eschrich, K. Biochemistry (2003) [Pubmed]
  13. Substrate specificity of the phosphorylated fructose-1,6-bisphosphatase dephosphorylating protein phosphatase from Saccharomyces cerevisiae. Manhart, A., Holzer, H. Yeast (1988) [Pubmed]
  14. Genetic manipulation of 6-phosphofructo-1-kinase and fructose 2,6-bisphosphate levels affects the extent to which benzoic acid inhibits the growth of Saccharomyces cerevisiae. Pearce, A.K., Booth, I.R., Brown, A.J. Microbiology (Reading, Engl.) (2001) [Pubmed]
  15. One-step purification of recombinant yeast 6-phosphofructo-2-kinase after the identification of contaminants by MALDI-TOF MS. Dihazi, H., Kessler, R., Eschrich, K. Protein Expr. Purif. (2001) [Pubmed]
  16. Sequence analysis of a 12 801 bp fragment of the left arm of yeast chromosome XV containing a putative 6-phosphofructo-2-kinase gene, a gene for a possible glycophospholipid-anchored surface protein and six other open reading frames. Aldea, M., Piedrafita, L., Casas, C., Casamayor, A., Khalid, H., Balcells, L., Ariño, J., Herrero, E. Yeast (1996) [Pubmed]
  17. The mechanism by which glucose increases fructose 2,6-bisphosphate concentration in Saccharomyces cerevisiae. A cyclic-AMP-dependent activation of phosphofructokinase 2. François, J., Van Schaftingen, E., Hers, H.G. Eur. J. Biochem. (1984) [Pubmed]
  18. Arg-257 and Arg-307 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bind the C-2 phospho group of fructose-2,6-bisphosphate in the fructose-2,6-bisphosphatase domain. Lin, K., Li, L., Correia, J.J., Pilkis, S.J. J. Biol. Chem. (1992) [Pubmed]
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