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Gene Review

GDA1  -  Gda1p

Saccharomyces cerevisiae S288c

Synonyms: GDPase, Guanosine-diphosphatase, SYGP-ORF16, YEL042W
 
 
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Disease relevance of GDA1

 

High impact information on GDA1

 

Biological context of GDA1

 

Anatomical context of GDA1

  • During the course of these studies we have found that two activities associated with the yeast Golgi apparatus, Kex2 endopeptidase and GDPase, are in separable subcompartments [9].
  • Replacement of the lumenal domain resulted in mislocalization of the chimeric protein from the Golgi to the vacuole, but a similar substitution leaving 34 amino acids of the GDPase lumenal domain intact was properly localized [10].
  • In Saccharomyces cerevisiae a Golgi lumenal GDPase (ScGda1p) generates GMP, the antiporter required for entry of GDP-mannose, from the cytosol, into the Golgi lumen [11].
  • The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties [12].
 

Associations of GDA1 with chemical compounds

  • We show that deletion of YND1, like deletion of GDA1, alters the sphingolipid profiles, suggesting that changes in sphingolipids compensate for lethality produced by changes in sterol composition and abundance [13].
  • The overexpression of the YND1 gene in the gda1 null mutant caused a significant increase in microsomal membrane-bound nucleoside phosphatase activity with a luminal orientation [6].
  • We report detection and characterization of a GDPmannose transport activity and a GDPase by yeast vesicles [8].
  • The Golgi guanosine diphosphatase is required for transport of GDP-mannose into the lumen of Saccharomyces cerevisiae Golgi vesicles [14].
  • PMR1 is found in fractions containing the Golgi marker guanosine diphosphatase, and is associated with an ATP-dependent, protonophore-insensitive 45Ca2+ uptake activity [15].
 

Physical interactions of GDA1

  • Our findings indicate that DPAP A is aberrantly transported to the cell surface but GDPase is not [16].
 

Other interactions of GDA1

  • YND1, a homologue of GDA1, encodes membrane-bound apyrase required for Golgi N- and O-glycosylation in Saccharomyces cerevisiae [6].
  • In the pmr1 mutant we found a decrease in activity of the P-type ATPase and of ATP-dependent, protonophore-insensitive Ca2+ transport in light membranes, that comigrate with the Golgi marker GDPase [17].
  • Using radiation inactivation and target analysis, we have now determined the functional molecular mass of the GDPase within the Golgi membrane and whether or not the enzyme has functional associations with other Golgi membrane proteins, including mannosyltransferases and the GDP-mannose transporter [18].
 

Analytical, diagnostic and therapeutic context of GDA1

  • Computer-aided sequence analysis of the EATPase superfamily indicates that the human UDPase is highly similar to two hypothetical proteins of the nematode Caenorhabditis elegans and to an unidentified 71.9-kDa yeast protein and is less related to the previously identified yeast Golgi GDPase [19].

References

  1. Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1. Recio, J.A., Páez, J.G., Maskeri, B., Loveland, M., Velasco, J.A., Notario, V. Cancer Res. (2000) [Pubmed]
  2. A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole. Vowels, J.J., Payne, G.S. EMBO J. (1998) [Pubmed]
  3. Biochemical requirements for the targeting and fusion of ER-derived transport vesicles with purified yeast Golgi membranes. Lupashin, V.V., Hamamoto, S., Schekman, R.W. J. Cell Biol. (1996) [Pubmed]
  4. Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. Graham, T.R., Seeger, M., Payne, G.S., MacKay, V.L., Emr, S.D. J. Cell Biol. (1994) [Pubmed]
  5. Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. Abeijon, C., Yanagisawa, K., Mandon, E.C., Häusler, A., Moremen, K., Hirschberg, C.B., Robbins, P.W. J. Cell Biol. (1993) [Pubmed]
  6. YND1, a homologue of GDA1, encodes membrane-bound apyrase required for Golgi N- and O-glycosylation in Saccharomyces cerevisiae. Gao, X.D., Kaigorodov, V., Jigami, Y. J. Biol. Chem. (1999) [Pubmed]
  7. Expression of the apyrase-like APY1 genes in roots of Medicago truncatula is induced rapidly and transiently by stress and not by Sinorhizobium meliloti or Nod factors. Navarro-Gochicoa, M.T., Camut, S., Niebel, A., Cullimore, J.V. Plant Physiol. (2003) [Pubmed]
  8. Topography of glycosylation in yeast: characterization of GDPmannose transport and lumenal guanosine diphosphatase activities in Golgi-like vesicles. Abeijon, C., Orlean, P., Robbins, P.W., Hirschberg, C.B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  9. Sec15 protein, an essential component of the exocytotic apparatus, is associated with the plasma membrane and with a soluble 19.5S particle. Bowser, R., Novick, P. J. Cell Biol. (1991) [Pubmed]
  10. A role for the lumenal domain in Golgi localization of the Saccharomyces cerevisiae guanosine diphosphatase. Vowels, J.J., Payne, G.S. Mol. Biol. Cell (1998) [Pubmed]
  11. The UDPase activity of the Kluyveromyces lactis Golgi GDPase has a role in uridine nucleotide sugar transport into Golgi vesicles. Lopez-Avalos, M.D., Uccelletti, D., Abeijon, C., Hirschberg, C.B. Glycobiology (2001) [Pubmed]
  12. The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties. Herrero, A.B., Uccelletti, D., Hirschberg, C.B., Dominguez, A., Abeijon, C. Eukaryotic Cell (2002) [Pubmed]
  13. Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles. Valachovic, M., Bareither, B.M., Shah Alam Bhuiyan, M., Eckstein, J., Barbuch, R., Balderes, D., Wilcox, L., Sturley, S.L., Dickson, R.C., Bard, M. Genetics (2006) [Pubmed]
  14. The Golgi guanosine diphosphatase is required for transport of GDP-mannose into the lumen of Saccharomyces cerevisiae Golgi vesicles. Berninsone, P., Miret, J.J., Hirschberg, C.B. J. Biol. Chem. (1994) [Pubmed]
  15. PMR1, a Ca2+-ATPase in yeast Golgi, has properties distinct from sarco/endoplasmic reticulum and plasma membrane calcium pumps. Sorin, A., Rosas, G., Rao, R. J. Biol. Chem. (1997) [Pubmed]
  16. Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiae. Seeger, M., Payne, G.S. J. Cell Biol. (1992) [Pubmed]
  17. Ca(2+)-ATPases of Saccharomyces cerevisiae: diversity and possible role in protein sorting. Okorokov, L.A., Lehle, L. FEMS Microbiol. Lett. (1998) [Pubmed]
  18. Regulation of yeast Golgi glycosylation. Guanosine diphosphatase functions as a homodimer in the membrane. Berninsone, P., Lin, Z.Y., Kempner, E., Hirschberg, C.B. J. Biol. Chem. (1995) [Pubmed]
  19. Golgi localization and functional expression of human uridine diphosphatase. Wang, T.F., Guidotti, G. J. Biol. Chem. (1998) [Pubmed]
 
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