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Gene Review

KLF7  -  Kruppel-like factor 7 (ubiquitous)

Homo sapiens

Synonyms: Krueppel-like factor 7, UKLF, Ubiquitous krueppel-like factor
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High impact information on KLF7

  • One of the loci is between the candidate genes KLF7 and CREB1, but given possible long-range effects on expression and the unknown importance of untranslated elements such as micro-RNAs, all four loci deserve attention as candidates [1].
  • Altogether, our results strongly suggest that MoKA and KLF7 interact functionally to regulate gene expression during cell differentiation and identify the cell cycle regulator p21(WAF1/Cip1) as one of the targeted genes [2].
  • KLF7, a member of the Krüppel-like transcription factor family, is believed to regulate neurogenesis and cell cycle progression [2].
  • Like CPBP/Zf9, UKLF can function as a transcription activator in co-transfection assays [3].
  • The carboxyl-terminal portion of UKLF contains three zinc fingers of the Cys2-His2 type and binds in vitro to the CACCC motif of the beta-globin promoter and to the Sp1 recognition sequence [3].

Biological context of KLF7

  • We also examined the effects of the overexpression of KLF7 on adipogenesis in 3T3-L1 cells [4].
  • CONCLUSIONS/INTERPRETATION: These results indicate that the gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes [4].
  • PNAS-133 gene was downregulated by morphine whereas the Krüppel-like factor 7 (KLF7), a zinc finger transcription factor, was upregulated by morphine [5].
  • The upregulation of KLF7 by morphine was further studied and found to be at both the transcriptional and the translational levels in a naloxone-reversible manner [5].
  • Functional clustering of DNA microarray data revealed that loss of KLF7 affects primarily the activity of genes involved in OSN differentiation, axonal growth, cytoskeletal dynamics, cell adhesion and synaptogenesis [6].

Anatomical context of KLF7

  • In human adipocytes overexpressing KLF7, the expression of adiponectin and leptin was decreased compared with that in control cells, whereas expression of IL-6 was increased [7].
  • These results suggest that KLF7 may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues [7].
  • We also found that the overexpression of KLF7 resulted in the decrease of hexokinase 2 expression in smooth muscle cells, and of glucose transporter 2 expression in the HepG2 cells [7].
  • Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons [6].
  • Gene targeting in mice has recently demonstrated that transcription factor KLF7 plays a critical role in neurite outgrowth and neuronal survival [6].

Associations of KLF7 with chemical compounds

  • The amino-terminal portion of UKLF consists of a hydrophobic region rich in serines and a negatively charged segment with several glutamic acid residues [3].

Regulatory relationships of KLF7

  • MoKA is a novel F-box containing protein that interacts with and stimulates the activity of transcription factor KLF7, a regulator of neuronal differentiation [8].
  • Cell transfection experiments, on the other hand, demonstrated that the promoters of the genes encoding the OSN-specific OMP and the adhesion molecule L1 are both activated by KLF7 binding to CACCC motifs [6].

Other interactions of KLF7

  • Here we report the identification of Luna, the Drosophila progenitor of the mammalian KLF6/KLF7 group [9].
  • Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7 [8].
  • Micro-opioids inhibited synthesis of common transcription factors AP-1, c-fos, NF-kappaB, and nuclear factor of activated T cells in activated or stimulated immune cells, whereas micro-opioids activated NF-kappaB, GATA-3, and Kruppel-like factor 7 transcription factors in non-stimulated immune cells [10].


  1. SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. Butcher, L.M., Meaburn, E., Knight, J., Sham, P.C., Schalkwyk, L.C., Craig, I.W., Plomin, R. Hum. Mol. Genet. (2005) [Pubmed]
  2. Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity. Smaldone, S., Laub, F., Else, C., Dragomir, C., Ramirez, F. Mol. Cell. Biol. (2004) [Pubmed]
  3. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors. Matsumoto, N., Laub, F., Aldabe, R., Zhang, W., Ramirez, F., Yoshida, T., Terada, M. J. Biol. Chem. (1998) [Pubmed]
  4. Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes. Kanazawa, A., Kawamura, Y., Sekine, A., Iida, A., Tsunoda, T., Kashiwagi, A., Tanaka, Y., Babazono, T., Matsuda, M., Kawai, K., Iiizumi, T., Fujioka, T., Imanishi, M., Kaku, K., Iwamoto, Y., Kawamori, R., Kikkawa, R., Nakamura, Y., Maeda, S. Diabetologia (2005) [Pubmed]
  5. Identification of opioid-regulated genes in human lymphocytic cells by differential display: upregulation of Krüppel-like factor 7 by morphine. Suzuki, S., Chuang, L.F., Doi, R.H., Chuang, R.Y. Exp. Cell Res. (2003) [Pubmed]
  6. Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons. Kajimura, D., Dragomir, C., Ramirez, F., Laub, F. Gene (2007) [Pubmed]
  7. Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. Kawamura, Y., Tanaka, Y., Kawamori, R., Maeda, S. Mol. Endocrinol. (2006) [Pubmed]
  8. Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7. Smaldone, S., Ramirez, F. Nucleic Acids Res. (2006) [Pubmed]
  9. Identification of the Drosophila progenitor of mammalian Krüppel-like factors 6 and 7 and a determinant of fly development. De Graeve, F., Smaldone, S., Laub, F., Mlodzik, M., Bhat, M., Ramirez, F. Gene (2003) [Pubmed]
  10. Signal transduction induced by opioids in immune cells: a review. Martin-Kleiner, I., Balog, T., Gabrilovac, J. Neuroimmunomodulation (2006) [Pubmed]
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