Disease relevance of PNMA1

• Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat [1].
• The human epidermoid carcinoma-derived cell line MA1, established by introduction of the adenovirus E1A 12 S cDNA linked to the hormone-inducible promoter, elicits apoptosis after induction of E1A12 S in response to dexamethasone [2].

High impact information on PNMA1

• The human epithermoid carcinoma-derived cell line MA1, established by introduction of the adenovirus E1A 12 S cDNA linked to the mouse mammary tumor virus long terminal repeat, elicits apoptosis after induction of E1A12S in response to dexamethasone [3].
• A selected clone (MA1) was found to have 82% DNA sequence homology to a segment of human Apo A1 [4].
• The bias reduction was most pronounced for MA1, moderate to large for MA2, and modest to moderate for TLS [5].
• For tracers with kinetics that permit t* to be accurately identified within the study duration, MA1 appears to be the best [5].
• The immunochemical properties of MA1, its tissue distribution, and sex differences in its concentration provide strong evidence that MA1 is identical to the previously described mouse major urinary protein [6].

Biological context of PNMA1

• The sequence of rat Ma1 (rPnma1) was determined by RT-PCR using primers for human PNMA1, followed by 5' and 3' genome walking [1].
• The cell lines partially refractory to apoptosis were established by introducing the expression plasmid for the adenovirus E1B 19k protein to MA1 cells [7].
• Thus a method based on TFA hydrolysis followed by the chromatographic separation and quantification of ribitol on a CarboPac MA1 column was developed [8].

Anatomical context of PNMA1

• Here, we report the correction and completion of the previously published prototype member PNMA1, the brain and testis restricted expression of a third member (PNMA3) and the sequences for further partially uncharacterized members of this novel neuronal protein family [9].
• Erythrocyte aggregation and elongation index (EI) (deformability) are measured at temperatures ranging from 5 degrees C to 37 degrees C by aggregometer MA1, and diffractometer Rheodyne SSD and the LORCA, respectively [10].

Associations of PNMA1 with chemical compounds

• Radical MA1 decayed at about 80 K, possibly into the C2 H adduct (MA4) [11].
• After induction of E1A in MA1 cells by dexamethasone, the level of p53 increased to about 10-fold within 24 h, and morphological changes characteristics of apoptosis began to be observed within 48 h [7].
• MA1 had a molecular weight of approximately 19,000 on Sephadex gel filtration and 18,000 to 21,000 on sodium dodecyl sulfate polyacrylamide gel electrophoresis [6].
• Carbohydrates such as alditols (polyols or sugar alcohols), monosaccharides and disaccharides are separated as anions by anion-exchange chromatography with a sodium hydroxide eluent, MA1 CarboPac column and pulsed amperometric detection [12].
• The material NaCeTi(2)O(6) has a distorted perovskite structure with sodium and cerium ions randomly occupying the A sites: Pnma, a = 5.4517(8) A, b = 7.7292(6) A, c =5.4573(3) A [13].

Other interactions of PNMA1

• Since only part reference of CSE database is published, the test result is base on the MA1 data set which reference points are published [14].
• The induction of an inflammatory response in the CNS following the adoptive transfer of rat Pnma1-specific T-cells demonstrates for the first time that a paraneoplastic autoantigen can initiate a pathogenic effector T-cell response [1].

Analytical, diagnostic and therapeutic context of PNMA1

• Analysis of the neutron diffraction pattern confirmed an average of the structure; the unit cell was orthorhombic at a = 8.8336(5) angstroms, b = 2.83387(18) angstroms, and c = 10.6535(7) angstroms (Pnma) [15].
• Respirators tested included the Bennett MA1 [16].
• The serum IgG from the patient contained antineuronal antibody(s) including an antibody to 35- to 37-kDa neuronal antigens called anti-Hu as demonstrated in Western blot [17].
• The structure of the compound in the crystal lattice was determined by low-temperature crystallography using a single crystal of H3GeONMe2 grown in situ [C2H9NOGe, orthorhombic, Pnma, Z = 4, a = 8.1280(12) A, b = 9.7037(15) A, c = 7.0722(12) A] [18].
• Reaction of hydrogen with Y(5)Ni(2)Te(2) causes a rumpling of the Y-Ni layers as determined by both single X-ray crystal means at 23 degrees C and neutron powder diffraction at -259 degrees C for Y(5)Ni(2)Te(2)D(0.41(1)), Pnma (No. 62), Z = 4 [19].

References