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Gene Review

dnaN  -  DNA polymerase III, beta subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3693, JW3678
 
 
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Disease relevance of dnaN

  • Tandem transcription termination sites in the dnaN gene of Escherichia coli [1].
  • A Bacillus subtilis dnaG mutant harbours a mutation in a gene homologous to the dnaN gene of Escherichia coli [2].
  • At 41 degrees C, multiplication of filamentous (inovirid) phages M13 and fd was restricted specifically in HC138 F+ dnaN bacteria [3].
  • When dnaN cells lysogenic for lambda i21 were grown at 42.5 degrees C for 60 min and then shifted down to 33 degrees C, a burst of lambda i21 occurred with concomitant cellular lysis, manifesting induction of the prophage development [3].
  • A specialized transducing lambda phage carrying the dnaN genes of Escherichia coli specifies two proteins of about 41 and 48 kilodaltons (kd) [4].
 

High impact information on dnaN

  • Characterization of dnaA and dnaN mutations that result in a constitutively high expression of RNR reveal this mechanism [5].
  • Stationary phase induction of dnaN and recF, two genes of Escherichia coli involved in DNA replication and repair [6].
  • Induction of dnaN and dnaQ gene expression in Escherichia coli by alkylation damage to DNA [7].
  • Four group II introns were found in an unusually intron-rich dnaN gene (encoding the beta subunit of DNA polymerase III) of the cyanobacterium Trichodesmium erythraeum, and they have strong similarities to two introns of the RIR gene (encoding ribonucleotide reductase) of the same organism [8].
  • The dnaN* transcript was shown to be induced upon treatment with nalidixic acid, and transcriptional dnaN*-cat gene fusions were UV inducible, suggesting induction of dnaN* at the transcriptional level [9].
 

Biological context of dnaN

 

Associations of dnaN with chemical compounds

 

Other interactions of dnaN

 

Analytical, diagnostic and therapeutic context of dnaN

References

  1. Tandem transcription termination sites in the dnaN gene of Escherichia coli. Armengod, M.E., García-Sogo, M., Pérez-Roger, I., Macián, F., Navarro-Aviñó, J.P. J. Biol. Chem. (1991) [Pubmed]
  2. A Bacillus subtilis dnaG mutant harbours a mutation in a gene homologous to the dnaN gene of Escherichia coli. Ogasawara, N., Moriya, S., Mazza, G., Yoshikawa, H. Gene (1986) [Pubmed]
  3. Effect of the dnaN mutation on the growth of small DNA phages. Taketo, A. Mol. Gen. Genet. (1981) [Pubmed]
  4. Identification of the dnaA and dnaN gene products of Escherichia coli. Yuasa, S., Sakakibara, Y. Mol. Gen. Genet. (1980) [Pubmed]
  5. A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli. Gon, S., Camara, J.E., Klungsøyr, H.K., Crooke, E., Skarstad, K., Beckwith, J. EMBO J. (2006) [Pubmed]
  6. Stationary phase induction of dnaN and recF, two genes of Escherichia coli involved in DNA replication and repair. Villarroya, M., Pérez-Roger, I., Macián, F., Armengod, M.E. EMBO J. (1998) [Pubmed]
  7. Induction of dnaN and dnaQ gene expression in Escherichia coli by alkylation damage to DNA. Quiñones, A., Kaasch, J., Kaasch, M., Messer, W. EMBO J. (1989) [Pubmed]
  8. An intron-encoded protein assists RNA splicing of multiple similar introns of different bacterial genes. Meng, Q., Wang, Y., Liu, X.Q. J. Biol. Chem. (2005) [Pubmed]
  9. Beta*, a UV-inducible smaller form of the beta subunit sliding clamp of DNA polymerase III of Escherichia coli. I. Gene expression and regulation. Paz-Elizur, T., Skaliter, R., Blumenstein, S., Livneh, Z. J. Biol. Chem. (1996) [Pubmed]
  10. Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12. Armengod, M.E., García-Sogo, M., Lambíes, E. J. Biol. Chem. (1988) [Pubmed]
  11. The nucleotide sequence of the dnaA gene and the first part of the dnaN gene of Escherichia coli K-12. Hansen, E.B., Hansen, F.G., von Meyenburg, K. Nucleic Acids Res. (1982) [Pubmed]
  12. Cloning and deletion mapping of the recF dnaN region of the Escherichia coli chromosome. Ream, L.W., Clark, A.J. Plasmid (1983) [Pubmed]
  13. DNA sequence and transcription of the region upstream of the E. coli gyrB gene. Adachi, T., Mizuuchi, K., Menzel, R., Gellert, M. Nucleic Acids Res. (1984) [Pubmed]
  14. Expression of the dnaN and dnaQ genes of Escherichia coli is inducible by mitomycin C. Kaasch, M., Kaasch, J., Quiñones, A. Mol. Gen. Genet. (1989) [Pubmed]
  15. Beta subunit of DNA polymerase III holoenzyme is induced upon ultraviolet irradiation or nalidixic acid treatment of Escherichia coli. Tadmor, Y., Bergstein, M., Skaliter, R., Shwartz, H., Livneh, Z. Mutat. Res. (1994) [Pubmed]
 
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