Disease relevance of Dupuytren's Contracture

• In eosinophilic fasciitis, nodular fasciitis, and Dupuytren's contracture, CTGF mRNA was also expressed partially in the fibroblasts of the fibrotic lesions [1].
• Overall, adhesive capsulitis was found in 10.9% (n = 15), Dupuytren's contracture in 8.8% (n = 12), limited joint mobility in 4.4% (n = 6), trigger finger in 2.9% (n = 4) and carpal tunnel syndrome in 9.5% (n = 13) of the patients [2].
• Chromosomal abnormalities in Dupuytren's contracture and carpal tunnel syndrome [3].

High impact information on Dupuytren's Contracture

• Response of Dupuytren's contracture to high-potency topical steroid [4].
• Basic fibroblast growth factor in Dupuytren's contracture [5].
• Local injections of tiopronin in Dupuytren's contracture [6].
• We present the first evidence that the palmar fascia is a target tissue for androgen action and that the expression of androgen receptors in Dupuytren's contracture is considerably higher than in the normal palmar fascia [7].
• Androgen receptors in Dupuytren's contracture [7].

Chemical compound and disease context of Dupuytren's Contracture

• The treatment of Dupuytren's contracture with flexor tendon sheath involvement-the sliding volar flap [8].
• Xanthine oxidase activity was also detected in Dupuytren's contracture palmar fascia [9].
• Nonsteroidal anti-inflammatory drugs and allopurinol are two agents that decrease oxygen free radical release and may inhibit or prevent Dupuytren's contracture [10].
• Simvastatin may be a useful therapy in Dupuytren contracture [11].
• Enzymes of glucose metabolism in palmar fascia and Dupuytren's contracture [12].

Anatomical context of Dupuytren's Contracture

• Lesions excised from nine patients undergoing surgery for Dupuytren's contracture (DC) and three normal fascia were examined for the presence of the angiogenic protein basic fibroblast growth factor (basic FGF) [5].

Gene context of Dupuytren's Contracture

• Patients with Dupuytren's contracture presented with a TIMP-1 concentration of 437 +/- 160 ng/ml, a significantly higher TIMP-1 concentration than that seen in the control patients, who had a concentration of 321 +/- 70 ng/ml (p < 0.05) [13].
• TIMP-1 and TIMP-2 could be detected in tissue of patients with Dupuytren's contracture, with an accumulation in proliferative areas [13].
• Because both these features characterize Dupuytren's contracture, we investigated a possible role for TGF-beta in the etiology of this disorder [14].
• Wound healing-associated proteins Hsp47 and fibronectin are elevated in Dupuytren's contracture [15].
• Our results suggest that growth factors such as TGF-beta and EGF may play a role in Dupuytren's contracture [14].

Analytical, diagnostic and therapeutic context of Dupuytren's Contracture

• Local anesthetics with epinephrine are safe in the treatment of Dupuytren's contracture, although both the use of digital epinephrine and the use of mechanical tourniquets carry the potential for complications [16].
• Acridine orange added to the primary fixative or reduced osmium tetroxide as postfixative have been used in order to localize by thin section electron microscopy glycoconjugates in the extracellular matrix of the normal palmar aponeurosis as well as in tissues at different stages of Dupuytren's contracture [17].

References