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MeSH Review


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Disease relevance of Fasciitis


High impact information on Fasciitis


Chemical compound and disease context of Fasciitis

  • Eosinophilic fasciitis and simvastatin [10].
  • The observations provide the first comparative molecular characterization of desmoid tumours and nodular fasciitis and suggest that selected tyrosine kinases, transcription factors, and members of the Wnt, TGF-beta, IFN, and TNF signalling pathways may be implicated in influencing and distinguishing their fate [11].
  • Rapidly growing asymptomatic, subcutaneous nodules. Nodular (pseudosarcomatous) fasciitis [12].
  • Possible association between eosinophilic fasciitis and subcutaneous heparin use [13].
  • This case highlights a possible association between the development of oesinophilic fasciitis and the use of medications such as phenytoin [14].

Biological context of Fasciitis


Anatomical context of Fasciitis

  • These findings suggest that TGF-beta 1 may play an important role in the development of the connective tissue alterations present in EMS-associated diffuse fasciitis [16].
  • Immunohistochemically, the spindle cells of the extracranial lesions and the one case of cranial fasciitis co-expressed vimentin and smooth muscle actin [17].
  • The coexistence of eosinophilic fasciitis and cellulitis in a patient with an abnormal circulating T-cell clone and increased IL-5 production are unique and might be responsible for the eosinophilia and eosinophil-mediated tissue injury [18].
  • Study of 18 biopsy specimens in 11 patients with L-tryptophan-related eosinophiliamyalgia (fasciitis) syndrome showed hyaline sclerodermoid changes [19].
  • A retrospective assessment of clinical features, response to treatment, and blinded review of biopsy specimens of skin and fascia in patients who had eosinophilic fasciitis with or without exposure to L-tryptophan disclosed no significant differences in the two groups [20].

Gene context of Fasciitis

  • All specimens except one specimen of nodular fasciitis showed immunoreactivity for alpha-smooth muscle actin and vimentin [21].
  • There was no immunreactivity for S-100, desmin, and p53 in nodular fasciitis [22].
  • The histopathologic features and immunomarkers indicative of myofibroblastic differentiation are seen in nodular fasciitis, whereas solitary fibrous tumor is CD34-positive; however, one instance was found to be positive for both markers [23].
  • No significant association between any HLA-A, -B, or -DR and eosinophilic fasciitis was seen [24].
  • Increased expression of transforming growth factor-beta1, fibronectin, and Types I, III, and VI collagen genes in fascial fibroblasts from patients with diffuse fasciitis with eosinophilia [25].

Analytical, diagnostic and therapeutic context of Fasciitis


  1. Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. Silver, R.M., Heyes, M.P., Maize, J.C., Quearry, B., Vionnet-Fuasset, M., Sternberg, E.M. N. Engl. J. Med. (1990) [Pubmed]
  2. L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat. Crofford, L.J., Rader, J.I., Dalakas, M.C., Hill, R.H., Page, S.W., Needham, L.L., Brady, L.S., Heyes, M.P., Wilder, R.L., Gold, P.W. J. Clin. Invest. (1990) [Pubmed]
  3. L-tryptophan ingestion associated with eosinophilic fasciitis but not progressive systemic sclerosis. Freundlich, B., Werth, V.P., Rook, A.H., O'Connor, C.R., Schumacher, H.R., Leyden, J.J., Stolley, P.D. Ann. Intern. Med. (1990) [Pubmed]
  4. Diffuse fasciitis and eosinophilia with symmetric polyarthritis. Rosenthal, J., Benson, M.D. Ann. Intern. Med. (1980) [Pubmed]
  5. Bronchiolitis and bronchitis in connective tissue disease. A possible relationship to the use of penicillamine. Epler, G.R., Snider, G.L., Gaensler, E.A., Cathcart, E.S., FitzGerald, M.X., Carrington, C.B. JAMA (1979) [Pubmed]
  6. Necrotising fasciitis after diflunisal for minor injury. Krige, J.E., Spence, R.A., Potter, P.C., Terblanche, J. Lancet (1985) [Pubmed]
  7. Fasciitis in chronic graft-versus-host disease. A clinicopathologic study of 14 cases. Janin, A., Socie, G., Devergie, A., Aractingi, S., Esperou, H., Vérola, O., Gluckman, E. Ann. Intern. Med. (1994) [Pubmed]
  8. Cimetidine in eosinophilic fasciitis. Herson, S., Brechignac, S., Godeau, P. Ann. Intern. Med. (1990) [Pubmed]
  9. Invasive soft tissue infections with Streptococcus pneumoniae in patients with systemic lupus erythematosus: case report and review of the literature. Hill, M.D., Karsh, J. Arthritis Rheum. (1997) [Pubmed]
  10. Eosinophilic fasciitis and simvastatin. Choquet-Kastylevsky, G., Kanitakis, J., Dumas, V., Descotes, J., Faure, M., Claudy, A. Arch. Intern. Med. (2001) [Pubmed]
  11. A gene expression signature that distinguishes desmoid tumours from nodular fasciitis. Bacac, M., Migliavacca, E., Stehle, J.C., McKee, T., Delorenzi, M., Coindre, J.M., Guillou, L., Stamenkovic, I. J. Pathol. (2006) [Pubmed]
  12. Rapidly growing asymptomatic, subcutaneous nodules. Nodular (pseudosarcomatous) fasciitis. Cartwright, L.E., Steinman, H.K. Archives of dermatology. (1988) [Pubmed]
  13. Possible association between eosinophilic fasciitis and subcutaneous heparin use. Cantini, F., Salvarani, C., Olivieri, I., Padula, A., Senesi, C., Bellandi, F., Truglia, M.C., Niccoli, L., Palchetti, R. J. Rheumatol. (1998) [Pubmed]
  14. The eosinophilic fasciitis syndrome after phenytoin (dilantin) therapy. Buchanan, R.R., Gordon, D.A., Muckle, T.J., McKenna, F., Kraag, G. J. Rheumatol. (1980) [Pubmed]
  15. Complete remission of relapsing eosinophilic fasciitis associated with bronchial asthma following regular steroid inhalation. Yamanishi, Y., Ishioka, S., Yamakido, M. Rheumatology (Oxford, England) (2000) [Pubmed]
  16. Elevated expression of the genes for transforming growth factor-beta 1 and type VI collagen in diffuse fasciitis associated with the eosinophilia-myalgia syndrome. Peltonen, J., Varga, J., Sollberg, S., Uitto, J., Jimenez, S.A. J. Invest. Dermatol. (1991) [Pubmed]
  17. Cranial and extracranial fasciitis of childhood: a clinicopathologic and immunohistochemical study. Sarangarajan, R., Dehner, L.P. Hum. Pathol. (1999) [Pubmed]
  18. Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon alfa. French, L.E., Shapiro, M., Junkins-Hopkins, J.M., Wolfe, J.T., Rook, A.H. J. Am. Acad. Dermatol. (2003) [Pubmed]
  19. Histopathologic features of the L-tryptophan-related eosinophilia-myalgia (fasciitis) syndrome. Winkelmann, R.K., Connolly, S.M., Quimby, S.R., Griffing, W.L., Lie, J.T. Mayo Clin. Proc. (1991) [Pubmed]
  20. Eosinophilic fasciitis associated with use of L-tryptophan: a case-control study and comparison of clinical and histopathologic features. Martin, R.W., Duffy, J., Lie, J.T. Mayo Clin. Proc. (1991) [Pubmed]
  21. Cytoskeletal characteristics of myofibroblasts in benign neoplastic and reactive fibroblastic lesions. Hasegawa, T., Hirose, T., Kudo, E., Abe, J., Hizawa, K. Virchows Archiv. A, Pathological anatomy and histopathology. (1990) [Pubmed]
  22. Vimentin, smooth muscle actin, desmin, S-100 protein, p53, and estrogen receptor expression in elastofibroma and nodular fasciitis. Kayaselçuk, F., Demirhan, B., Kayaselçuk, U., Ozerdem, O.R., Tuncer, I. Annals of diagnostic pathology. (2002) [Pubmed]
  23. Nodular fasciitis and solitary fibrous tumor of the oral region: tumors of fibroblast heterogeneity. Eversole, L.R., Christensen, R., Ficarra, G., Pierleoni, L., Sapp, J.P. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1999) [Pubmed]
  24. Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases. Lakhanpal, S., Ginsburg, W.W., Michet, C.J., Doyle, J.A., Moore, S.B. Semin. Arthritis Rheum. (1988) [Pubmed]
  25. Increased expression of transforming growth factor-beta1, fibronectin, and Types I, III, and VI collagen genes in fascial fibroblasts from patients with diffuse fasciitis with eosinophilia. Kahari, L., Jimenez, S.A. J. Rheumatol. (1996) [Pubmed]
  26. Fascial Tc-99m MDP uptake in eosinophilic fasciitis as demonstrated by SPECT. Flamen, P., Dierickx, L., Everaert, H., Reychler, R., Bruyland, M., Franken, P.R., Bossuyt, A. Clinical nuclear medicine. (1997) [Pubmed]
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