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Disease relevance of Iridocyclitis


High impact information on Iridocyclitis

  • HLA-DR5 is associated with a chronic iridocyclitis and juvenile rheumatoid arthritis with onset in early childhood [6].
  • To test this observation further, 38 families, the probands of which have chronic iridocyclitis and juvenile rheumatoid arthritis, were HLA typed so that haplotypes associated with disease could be established [6].
  • Children who develop iridocyclitis are predominantly girls whose sera are positive for antinuclear antibodies [7].
  • An ANA positivity in the child with pauciarticular arthritis should always prompt frequent slit-lamp examinations for asymptomatic iridocyclitis [8].
  • Nine of 20 symptomatic patients had low serum C3 levels, compared to none of 31 asymptomatic patients (P less than 0.005); no patient had iridocyclitis or a positive test for antinuclear antibodies [9].

Chemical compound and disease context of Iridocyclitis


Biological context of Iridocyclitis


Anatomical context of Iridocyclitis


Gene context of Iridocyclitis

  • The analysis was limited to alleles known to be associated with an increased or decreased risk of early-onset pauciarticular juvenile rheumatoid arthritis or of chronic iridocyclitis in this form of juvenile rheumatoid arthritis [17].
  • Patients with both the DRB1* 1104 and DPB1* 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients [17].
  • Antinuclear antibody (ANA) seropositivity correlated with DR5 (p less than 0.02), and in children with chronic iridocyclitis (CIR) Bw62 incidence was raised (p less than 0.03) and B44 reduced (p less than 0.03) [18].
  • All the patients with iridocyclitis had either a DR1 or DR3 allele, except for one child [19].
  • The indications for corticosteroid usage in JRA might be summarized as: Severe systemic disease unresponsive to salicylates Chronic iridocyclitis unresponsive to topical steroids [20].

Analytical, diagnostic and therapeutic context of Iridocyclitis


  1. Low mature TGF-beta 2 levels in aqueous humor during uveitis. de Boer, J.H., Limpens, J., Orengo-Nania, S., de Jong, P.T., La Heij, E., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  2. Ankylosing spondylitis and inflammatory bowel disease. III. Clinical characteristics and results of histocompatibility typing (HLA B27) in 50 patients with both ankylosing spondylitis and inflammatory bowel disease. Dekker-Saeys, B.J., Meuwissen, S.G., Van Den Berg-Loonen, E.M., De Haas, W.H., Meijers, K.A., Tytgat, G.N. Ann. Rheum. Dis. (1978) [Pubmed]
  3. Autoantibodies to DEK oncoprotein in systemic lupus erythematosus (SLE). Wichmann, I., Respaldiza, N., Garcia-Lozano, J.R., Montes, M., Sanchez-Roman, J., Nuñez-Roldan, A. Clin. Exp. Immunol. (2000) [Pubmed]
  4. Delayed hypersensitivity to a corticosteroid suspension containing methylprednisolone. Two cases of conjunctival inflammation after retrobulbar injection. Mathias, C.G., Robertson, D.B. Archives of dermatology. (1985) [Pubmed]
  5. Intravitreal gas injection for hypotony after cataract surgery. Weinberger, D., Stiebel, H., Lusky, M., Hodish, I., Yassur, Y. Journal of cataract and refractive surgery. (1998) [Pubmed]
  6. Inherited predisposition to iridocyclitis with juvenile rheumatoid arthritis: selectivity among HLA-DR5 haplotypes. Miller, M.L., Fraser, P.A., Jackson, J.M., Larson, M.G., Petersen, R.A., Chylack, L.T., Glass, D.N. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  7. Clinical patterns of chronic iridocyclitis in children with juvenile rheumatoid arthritis. Cassidy, J.T., Sullivan, D.B., Petty, R.E. Arthritis Rheum. (1977) [Pubmed]
  8. Serologic studies in juvenile rheumatoid arthritis: a review. Petty, R.E., Cassidy, J.T., Sullivan, D.B. Arthritis Rheum. (1977) [Pubmed]
  9. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Steere, A.C., Malawista, S.E., Snydman, D.R., Shope, R.E., Andiman, W.A., Ross, M.R., Steele, F.M. Arthritis Rheum. (1977) [Pubmed]
  10. Iridocyclitis and an iris mass associated with secondary syphilis. McCarron, M.J., Albert, D.M. Ophthalmology (1984) [Pubmed]
  11. Anterior segment ischemia in Fuchs' heterochromic cyclitis. Berger, B.B., Tessler, H.H., Kottow, M.H. Arch. Ophthalmol. (1980) [Pubmed]
  12. Chlorambucil in the treatment of iridocyclitis in juvenile rheumatoid arthritis. Mehra, R., Moore, T.L., Catalano, D., Neucks, S.H., Zuckner, J. J. Rheumatol. (1981) [Pubmed]
  13. Lipopolysaccharide tolerance inhibits eye inflammation. I. Reduced immune complex or lipopolysaccharide effects. Howes, E.L., Goldyne, M.E., Perez, H.D., Goldstein, I.M., Rosenbaum, J.T. Arch. Ophthalmol. (1985) [Pubmed]
  14. Reduction of macular oedema by acetazolamide in patients with chronic iridocyclitis: a randomised prospective crossover study. Farber, M.D., Lam, S., Tessler, H.H., Jennings, T.J., Cross, A., Rusin, M.M. The British journal of ophthalmology. (1994) [Pubmed]
  15. Fuch's heterochromic cyclitis and HLA histocompatibility antigens. Muñoz, G., López-Corell, M.P., Taboada, J.F., Ferrer, E., Díaz-Llopis, M. International ophthalmology. (1994) [Pubmed]
  16. Genetic and clinical determinants for the T cell mediated immune response against the cornea specific protein BCP 54. Jager, M.J., Völker-Dieben, H.J., de Waal, L., Kok, F.G., Broersma, L., van der Gaag, R. The British journal of ophthalmology. (1994) [Pubmed]
  17. Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis. Melin-Aldana, H., Giannini, E.H., Taylor, J., Lovell, D.J., Levinson, J.E., Passo, M.H., Ginsberg, J., Burke, M.J., Glass, D.N. J. Pediatr. (1992) [Pubmed]
  18. Genetic susceptibility to early onset pauciarticular juvenile chronic arthritis: a study of HLA and complement markers in 158 British patients. Hall, P.J., Burman, S.J., Laurent, M.R., Briggs, D.C., Venning, H.E., Leak, A.M., Bedford, P.A., Ansell, B.M. Ann. Rheum. Dis. (1986) [Pubmed]
  19. Prevalence of human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti children with juvenile rheumatoid arthritis. Alsaeid, K., Haider, M.Z., Kamal, H., Srivastva, B.S., Ayoub, E.M. Eur. J. Immunogenet. (2002) [Pubmed]
  20. Corticosteroids in juvenile rheumatoid arthritis. Schaller, J.G. Arthritis Rheum. (1977) [Pubmed]
  21. Antibodies to iris and retina detected in sera from patients with juvenile rheumatoid arthritis with iridocyclitis by indirect immunofluorescence studies on human eye tissue. Uchiyama, R.C., Osborn, T.G., Moore, T.L. J. Rheumatol. (1989) [Pubmed]
  22. Lepromatous iridocyclitis diagnosed by anterior chamber paracentesis. Michelson, J.B., Roth, A.M., Waring, G.O. Am. J. Ophthalmol. (1979) [Pubmed]
  23. Recurrent idiopathic iridocyclitis after autologous peripheral blood stem-cell transplantation followed by G-CSF administration for acute lymphoblastic leukemia. Tsuchiyama, J., Imajo, K., Sakaguchi, N., Yoshino, T., Suzaki, N., Kondo, E., Kawata, N., Okada, K., Maeda, T., Tomiyama, Y., Tsubota, T. Ann. Hematol. (2000) [Pubmed]
  24. Acyclovir in herpes simplex keratitis. Falcon, M.G. J. Infect. (1983) [Pubmed]
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