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MeSH Review

Corneal Diseases

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Disease relevance of Corneal Diseases


High impact information on Corneal Diseases

  • The evolution of the corneal disease during treatment and follow-up was evaluated by slit-lamp examination, photography, fluorescein-dye testing, and tests of corneal sensitivity and best corrected visual acuity [6].
  • Treatment decreased corneal disease severity and reduced significantly the number of B7-positive cells as well as the recruitment and activation of CD4(+) T cells in the cornea [7].
  • A combination of subconjunctival and i.p. administration of IL-1beta polyclonal Ab significantly reduced corneal disease [8].
  • Systemic neutralization of IL-2 after the onset of corneal disease resulted in a rapid regression of inflammation and complete resolution in 50% of the treated mice [9].
  • CONCLUSIONS: Bacterial toxins, and especially alpha-toxin, can mediate corneal disease in mice [10].

Chemical compound and disease context of Corneal Diseases


Biological context of Corneal Diseases

  • RESULTS: For the cytotoxic strain, mutation of either exoU or exoT alone had little effect on virulence, whereas simultaneous mutation of both exoT and exoU or of exsA resulted in a significantly reduced capacity to cause corneal disease [16].
  • Beside oncology, new therapeutic applications of SS analogs could be presumed among others in ophthalmology; it concerns the treatment of progressive Graves-Basedow ophtalmopathy, diabetic retinopathy, glaucoma and corneal diseases connected with corneal vascularization [17].

Anatomical context of Corneal Diseases


Gene context of Corneal Diseases


Analytical, diagnostic and therapeutic context of Corneal Diseases


  1. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness). Pearlman, E., Lass, J.H., Bardenstein, D.S., Kopf, M., Hazlett, F.E., Diaconu, E., Kazura, J.W. J. Exp. Med. (1995) [Pubmed]
  2. A therapeutic vaccine that reduces recurrent herpes simplex virus type 1 corneal disease. Nesburn, A.B., Burke, R.L., Ghiasi, H., Slanina, S.M., Wechsler, S.L. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  3. Effect of famciclovir on herpes simplex virus type 1 corneal disease and establishment of latency in rabbits. Loutsch, J.M., Sainz, B., Marquart, M.E., Zheng, X., Kesavan, P., Higaki, S., Hill, J.M., Tal-Singer, R. Antimicrob. Agents Chemother. (2001) [Pubmed]
  4. Herpes simplex virus infections of the eye and their management with acyclovir. Falcon, M.G. J. Antimicrob. Chemother. (1983) [Pubmed]
  5. Altered type VI collagen synthesis by keratoconus keratocytes in vitro. Chwa, M., Kenney, M.C., Khin, H., Brown, D.J. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  6. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. Lambiase, A., Rama, P., Bonini, S., Caprioglio, G., Aloe, L. N. Engl. J. Med. (1998) [Pubmed]
  7. B7/CD28 costimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice. Hazlett, L.D., McClellan, S., Barrett, R., Rudner, X. J. Immunol. (2001) [Pubmed]
  8. Prolonged elevation of IL-1 in Pseudomonas aeruginosa ocular infection regulates macrophage-inflammatory protein-2 production, polymorphonuclear neutrophil persistence, and corneal perforation. Rudner, X.L., Kernacki, K.A., Barrett, R.P., Hazlett, L.D. J. Immunol. (2000) [Pubmed]
  9. Proinflammatory functions of IL-2 in herpes simplex virus corneal infection. Tang, Q., Chen, W., Hendricks, R.L. J. Immunol. (1997) [Pubmed]
  10. Effects of toxin production in a murine model of Staphylococcus aureus keratitis. Girgis, D.O., Sloop, G.D., Reed, J.M., O'Callaghan, R.J. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  11. Altered antigenicity of keratan sulfate proteoglycan in selected corneal diseases. Funderburgh, J.L., Funderburgh, M.L., Rodrigues, M.M., Krachmer, J.H., Conrad, G.W. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  12. Herpetic keratitis in experimental vitamin A deficiency. Hatchell, D.L., O'Brien, W.J., Taylor, J.L., Hyndiuk, R.A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  13. Oral antiviral drugs in experimental herpes simplex keratitis. Kaufman, H.E., Varnell, E.D., Centifanto-Fitzgerald, Y.M., De Clercq, E., Kissling, G.E. Antimicrob. Agents Chemother. (1983) [Pubmed]
  14. Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug. Asai, T., Nakagami, T., Mochizuki, M., Hata, N., Tsuchiya, T., Hotta, Y. Cornea (2006) [Pubmed]
  15. Vitamin A is present as retinol in the tears of humans and rabbits. Ubels, J.L., MacRae, S.M. Curr. Eye Res. (1984) [Pubmed]
  16. Contribution of ExsA-regulated factors to corneal infection by cytotoxic and invasive Pseudomonas aeruginosa in a murine scarification model. Lee, E.J., Cowell, B.A., Evans, D.J., Fleiszig, S.M. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  17. Perspectives of new potential therapeutic applications of somatostatin analogs. Pawlikowski, M., Melen-Mucha, G. Neuro Endocrinol. Lett. (2003) [Pubmed]
  18. Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. Tumpey, T.M., Cheng, H., Yan, X.T., Oakes, J.E., Lausch, R.N. J. Leukoc. Biol. (1998) [Pubmed]
  19. Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. Alvarado, J.A., Underwood, J.L., Green, W.R., Wu, S., Murphy, C.G., Hwang, D.G., Moore, T.E., O'Day, D. Arch. Ophthalmol. (1994) [Pubmed]
  20. Clinical, electron microscopic, and immunohistochemical study of the corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. Rodrigues, M.M., Stulting, R.D., Waring, G.O. Am. J. Ophthalmol. (1986) [Pubmed]
  21. Distribution of TFF peptides in corneal disease and pterygium. Steven, P., Schäfer, G., Nölle, B., Hinz, M., Hoffmann, W., Paulsen, F. Peptides (2004) [Pubmed]
  22. Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas. Lambiase, A., Manni, L., Bonini, S., Rama, P., Micera, A., Aloe, L. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  23. Delineation of a 1-cM region on distal 5q containing the locus for corneal dystrophies Groenouw type I and lattice type I and exclusion of the candidate genes SPARC and LOX. Korvatska, E., Munier, F.L., Zografos, L., Ahmad, F., Faggioni, R., Dolivo-Beuret, A., Uffer, S., Pescia, G., Schorderet, D.F. Eur. J. Hum. Genet. (1996) [Pubmed]
  24. Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study. Nielsen, K., Vorum, H., Fagerholm, P., Birkenkamp-Demtröder, K., Honoré, B., Ehlers, N., Orntoft, T.F. Exp. Eye Res. (2006) [Pubmed]
  25. Ocular surface findings in Hallopeau-Siemens subtype of dystrophic epidermolysis bullosa: report of a case and literature review. Matsumoto, Y., Dogru, M., Tsubota, K. Cornea (2005) [Pubmed]
  26. Clinical experience with butyl-2-cyanoacrylate adhesive in the management of canine and feline corneal disease. Watté, C.M., Elks, R., Moore, D.L., McLellan, G.J. Veterinary ophthalmology. (2004) [Pubmed]
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