Disease relevance of Peliosis Hepatis

• Moreover, this VEGF-induced syndrome resembles peliosis hepatis, a rare human condition that is encountered in the setting of advanced malignancies, high-dose androgen therapy, and Bartonella henselae infection [1].
• This suggests that some liver vascular disorders caused by thiopurines (6-thioguanine, azathioprine and 6-mercaptopurine), particularly peliosis hepatis, veno-occlusive disease, sinusoidal dilatation and perisinusoidal fibrosis, might be related syndromes caused by similar lesions at different sites [2].
• The development of peliosis hepatis was completely abrogated when melanoma growth was inhibited by administration of dexamethasone [3].
• We report subacute necrosis, peliosis hepatis, venoocclusive disease and hepatic angiosarcoma after long-term administration of urethane [4].
• Two cases of peliosis hepatis, treated with a large dose of predonine for aplastic anemia and multiple myeloma, respectively, were reported [5].

High impact information on Peliosis Hepatis

• Peliosis hepatis associated with administration of oxymetholone [6].
• Peliosis hepatis induced by 6-thioguanine administration [2].
• This report shows that 6-thioguanine, a thiopurine already reported to be responsible for veno-occlusive disease of the liver, can induce peliosis hepatis [2].
• This suggests that cases of peliosis hepatis and nodular transformation which appear after renal transplantation are associated with immunosuppressants, and that cyclosporin treatment may also affect the morphogenesis of nodular transformation [7].
• Benign hepatic tumors and peliosis hepatis developed in a patient who had received androgen therapy for three years [8].

Chemical compound and disease context of Peliosis Hepatis

• Peliosis hepatis, a condition characterized by the presence of blood-filled lacunar spaces in the liver, has been described primarily in patients on androgenic steroid medication and patients with tuberculosis [9].
• A case of peliosis hepatis in association with tamoxifen therapy [10].
• The present findings suggest that sinusoidal barrier abnormalities might constitute a major event in the pathophysiology of vitamin A-induced liver injury as well as of peliosis hepatis [11].
• Peliosis hepatis was characterized as showing a significantly long T(2) relaxation time of 57.9 +/- 13.3 ms (mean +/- standard deviation) compared with 41.3 +/- 1.7 ms in normal liver, and prolonged enhancement after a gadolinium injection [12].
• Marked sinusoidal dilatation, disruption of cell cords and reticulin fiber framework, and cystic dilatation of sinusoids seem to represent the developmental stages of peliosis hepatis in sequence [13].

Biological context of Peliosis Hepatis

• Blood volume measurements may be of value in forecasting the possible development of peliosis hepatis in humans, which may occur in association with regular long-term anabolic steroid therapy [14].

Anatomical context of Peliosis Hepatis

• It is suggested that damage to sinusoidal endothelium, with impairment of its ability to maintain sinusoidal collagenous reticulin, is a mechanism by which oxymetholone can cause peliosis hepatis in these patients [15].
• This article reviews the primary circulatory liver diseases, which include Budd-Chiari syndrome, obstruction of the hepatic portion of the inferior vena cava, portal vein thrombosis, sinusoidal obstruction syndrome (veno-occlusive disease), nodular regenerative hyperplasia, and peliosis hepatis [16].

Gene context of Peliosis Hepatis

• Peliosis hepatis causing inferior vena cava compression in a 3-year-old child [17].
• Peliosis hepatis associated with idiopathic restrictive cardiomyopathy [18].
• Severe acute pancreatitis associated with peliosis hepatis in a patient with systemic lupus erythematosus [19].
• The other 2 patients were White children who presented with peliosis hepatis after receiving methyltestosterone and oxymetholone for 8 years and oxymetholone for 5 years, respectively [20].

Analytical, diagnostic and therapeutic context of Peliosis Hepatis

• Fifty-two autopsies of patients who had undergone hemodialysis and had received testosterone enanthate, were reviewed for evidence of peliosis hepatis and liver neoplasms [21].

References