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Chemical Compound Review

Mesteron     (8R,9S,10R,13S,14S,17S)-17- hydroxy-10,13...

Synonyms: Android, Mesterone, Metandren, Methitest, Testred, ...
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Disease relevance of Dianabol


Psychiatry related information on Dianabol


High impact information on Dianabol


Chemical compound and disease context of Dianabol


Biological context of Dianabol

  • Adiposity was determined as the ratio between total body fat tissue and total body lean tissue, while fat distribution was taken as the ratio between the mass of fat tissue in the android (central) and gynoid (hip and thigh) regions [18].
  • Another common ovarian morphology in women with hyperandrogenism is polycystic ovaries, which cluster with hirsutism, anovulation, infertility, gonadotropin secretion abnormalities, android fat distribution, and many important cardiovascular disease risk factors [19].
  • DEXA measurements thus clearly demonstrated that sex differences in total fat mass were opposite those of android fat, and that marked menopausal changes in fat mass and its distribution existed [20].
  • To determine if male hormones could also be neuroprotective, we investigated the effect of testosterone, methyltestosterone, and epitestosterone at physiological concentrations on primary cultures of human neurons induced to undergo apoptosis by serum deprivation [21].
  • The larvae (XX) were produced artificially by mating normal females (XX) with gynogenetic diploid males (XX) which had been sex-reversed to phenotypic males by 17alpha-methyltestosterone [22].

Anatomical context of Dianabol

  • These results support the hypothesis that PAI-1 expression in human adipose tissue is controlled by insulin and glucocorticoids and may help to explain the increase in plasma PAI-1 levels observed in patients with android obesity [23].
  • While obese women with abdominal (android) fat distribution are more insulin resistant than those with peripheral (gynecoid) obesity, in nonobese women, the relationship between abdominal fat and insulin resistance is unknown [24].
  • Muscle tissue in women with Cushing's syndrome had a relatively low proportion of type I (30%) and a high proportion of type IIB (32%) muscle fibers, similar to those in android obesity (45% and 25%, respectively) and in contrast to fiber composition in gynoid obesity (55% and 12%, respectively) [25].
  • The maximum labelling indices which appeared on days 2 or 3 of administration of methyltestosterone were 24.3, 8.4, 9.6, 21.6 and 13.7% for the ventral, lateral and dorsal prostate, seminal vesicle and coagulating glands, respectively [26].
  • However, to the best of our knowledge this is the first case of emergency resection of a spontaneously ruptured liver cell adenoma in a transexual treated with long term methyltestosterone [27].

Associations of Dianabol with other chemical compounds


Gene context of Dianabol

  • We investigated the influence of a TNF antagonist [Ro 45-2081, a recombinant fusion protein that consists of the soluble TNF-receptor (p55) linked to the Fc portion of human IgG1] on insulin sensitivity of patients with android obesity [31].
  • The RBA of methyltestosterone was 44% for the androgen receptor, but 11% for SHBG [32].
  • Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity [33].
  • These results demonstrate that in women who practise intense exercise there are significant differences in body fat distribution in comparison to sedentary women, with a marked less amount of android fat, and suggest that this difference may be related to a reduced response of the pituitary-adrenal axis to CRH [34].
  • It is concluded that (1) obesity rather than diabetes itself plays a major role for the increased PAI-1 levels in NIDDM; (2) resistance to the antilipolytic effect of insulin, resulting in increased FFA concentrations, may participate in producing elevated PAI-1 levels in android obese subjects [35].

Analytical, diagnostic and therapeutic context of Dianabol


  1. Platelet activation in obese women: role of inflammation and oxidant stress. Davì, G., Guagnano, M.T., Ciabattoni, G., Basili, S., Falco, A., Marinopiccoli, M., Nutini, M., Sensi, S., Patrono, C. JAMA (2002) [Pubmed]
  2. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Tounian, P., Aggoun, Y., Dubern, B., Varille, V., Guy-Grand, B., Sidi, D., Girardet, J.P., Bonnet, D. Lancet (2001) [Pubmed]
  3. Body weight and bone mineral density in postmenopausal women with primary hyperparathyroidism. Grey, A.B., Evans, M.C., Stapleton, J.P., Reid, I.R. Ann. Intern. Med. (1994) [Pubmed]
  4. Methyltestosterone therapy in hereditary angioedema. Sheffer, A.L., Fearon, D.T., Austen, K.F. Ann. Intern. Med. (1977) [Pubmed]
  5. Toward an empirically derived typology of obese persons. Allison, D.B., Heshka, S. International journal of obesity. (1991) [Pubmed]
  6. Body composition characteristics and fat distribution patterns in young infertile women. Kirchengast, S., Huber, J. Fertil. Steril. (2004) [Pubmed]
  7. Female hypoactive sexual desire disorder due to androgen deficiency: clinical and psychometric issues. Warnock, J.K., Bundren, J.C., Morris, D.W. Psychopharmacology bulletin. (1997) [Pubmed]
  8. The shapes of the female pelvis. Contributing factors. Abitbol, M.M. The Journal of reproductive medicine. (1996) [Pubmed]
  9. Life style and the risk of development of circulatory system diseases. Borzecki, A., Zółkowska, D., Sieklucka-Dziuba, M. Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. (2002) [Pubmed]
  10. Cerebrospinal fluid and behavioral changes after methyltestosterone administration: preliminary findings. Daly, R.C., Su, T.P., Schmidt, P.J., Pickar, D., Murphy, D.L., Rubinow, D.R. Arch. Gen. Psychiatry (2001) [Pubmed]
  11. Abdominal obesity and breast cancer risk. Schapira, D.V., Kumar, N.B., Lyman, G.H., Cox, C.E. Ann. Intern. Med. (1990) [Pubmed]
  12. Association of body fat distribution and cardiovascular risk factors in children and adolescents. Daniels, S.R., Morrison, J.A., Sprecher, D.L., Khoury, P., Kimball, T.R. Circulation (1999) [Pubmed]
  13. Influence of glucocorticoid, estrogen, and androgen hormones on transformation of human cells in vitro by feline sarcoma virus. Schaller, J.P., Milo, G.E., Blakeslee, J.R., Olsen, R.G., Yohn, D.S. Cancer Res. (1976) [Pubmed]
  14. Androgenic effects of oral contraceptives: implications for patient compliance. Jones, E.E. Am. J. Med. (1995) [Pubmed]
  15. Exercise in therapy and prevention of type II diabetes. Implications for blacks. Ruderman, N., Apelian, A.Z., Schneider, S.H. Diabetes Care (1990) [Pubmed]
  16. Influence of obesity and body fat distribution on postprandial lipemia and triglyceride-rich lipoproteins in adult women. Mekki, N., Christofilis, M.A., Charbonnier, M., Atlan-Gepner, C., Defoort, C., Juhel, C., Borel, P., Portugal, H., Pauli, A.M., Vialettes, B., Lairon, D. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  17. Hormonal control of cholesterol cholelithiasis in the female hamster. Ayyad, N., Cohen, B.I., Mosbach, E.H., Mikami, T., Mikami, Y., Ohshima, A. J. Lipid Res. (1995) [Pubmed]
  18. Body fat distribution, rather than overall adiposity, influences serum lipids and lipoproteins in healthy men independently of age. Walton, C., Lees, B., Crook, D., Worthington, M., Godsland, I.F., Stevenson, J.C. Am. J. Med. (1995) [Pubmed]
  19. Obesity, lipids, cardiovascular risk, and androgen excess. Wild, R.A. Am. J. Med. (1995) [Pubmed]
  20. Sex- and menopause-associated changes in body-fat distribution. Ley, C.J., Lees, B., Stevenson, J.C. Am. J. Clin. Nutr. (1992) [Pubmed]
  21. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. Hammond, J., Le, Q., Goodyer, C., Gelfand, M., Trifiro, M., LeBlanc, A. J. Neurochem. (2001) [Pubmed]
  22. Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in the Japanese flounder (Paralichthys olivaceus). Kitano, T., Takamune, K., Kobayashi, T., Nagahama, Y., Abe, S.I. J. Mol. Endocrinol. (1999) [Pubmed]
  23. Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue. Morange, P.E., Aubert, J., Peiretti, F., Lijnen, H.R., Vague, P., Verdier, M., Négrel, R., Juhan-Vague, I., Alessi, M.C. Diabetes (1999) [Pubmed]
  24. Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Carey, D.G., Jenkins, A.B., Campbell, L.V., Freund, J., Chisholm, D.J. Diabetes (1996) [Pubmed]
  25. Muscle and adipose tissue morphology and metabolism in Cushing's syndrome. Rebuffé-Scrive, M., Krotkiewski, M., Elfverson, J., Björntorp, P. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  26. Proliferative response of rat accessory sex organs to dietary sex hormones after castration or initial dietary administration of estrogen. Shirai, T., Ikawa, E., Imaida, K., Tagawa, Y., Ito, N. J. Urol. (1987) [Pubmed]
  27. Spontaneous rupture of a liver cell adenoma after long term methyltestosterone: report of a case successfully treated by emergency right hepatic lobectomy. Bird, D., Vowles, K., Anthony, P.P. The British journal of surgery. (1979) [Pubmed]
  28. Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Pugeat, M.M., Dunn, J.F., Nisula, B.C. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  29. Use of the three-spined stickleback (Gasterosteus aculeatus) as a sensitive in vivo test for detection of environmental antiandrogens. Katsiadaki, I., Morris, S., Squires, C., Hurst, M.R., James, J.D., Scott, A.P. Environ. Health Perspect. (2006) [Pubmed]
  30. Liver function in postmenopausal women on estrogen-androgen hormone replacement therapy: a meta-analysis of eight clinical trials. Gitlin, N., Korner, P., Yang, H.M. Menopause (New York, N.Y.) (1999) [Pubmed]
  31. No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients. Paquot, N., Castillo, M.J., Lefèbvre, P.J., Scheen, A.J. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  32. Binding of 17-alpha-methyltestosterone in vitro to human sex hormone binding globulin and rat ventral prostate androgen receptors. Wiita, B., Artis, A., Ackerman, D.M., Longcope, C. Therapeutic drug monitoring. (1995) [Pubmed]
  33. Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. Speer, G., Cseh, K., Winkler, G., Vargha, P., Braun, E., Takács, I., Lakatos, P. Eur. J. Endocrinol. (2001) [Pubmed]
  34. Body-fat distribution and responsiveness of the pituitary-adrenal axis to corticotropin-releasing-hormone stimulation in sedentary and exercising women. Fabbri, A., Giannini, D., Aversa, A., De Martino, M.U., Fabbrini, E., Franceschi, F., Moretti, C., Frajese, G., Isidori, A. J. Endocrinol. Invest. (1999) [Pubmed]
  35. Are free fatty acids related to plasma plasminogen activator inhibitor 1 in android obesity? Bastard, J.P., Bruckert, E., Robert, J.J., Ankri, A., Grimaldi, A., Jardel, C., Hainque, B. Int. J. Obes. Relat. Metab. Disord. (1995) [Pubmed]
  36. Liver damage from long-term methyltestosterone. Westaby, D., Ogle, S.J., Paradinas, F.J., Randell, J.B., Murray-Lyon, I.M. Lancet (1977) [Pubmed]
  37. Effect of 4-wk treatment of obesity by very-low-calorie diet on anthropometric, metabolic, and hormonal indexes. Hainer, V., Stich, V., Kunesová, M., Parízková, J., Zák, A., Wernischová, V., Hrabák, P. Am. J. Clin. Nutr. (1992) [Pubmed]
  38. Association between circulating adiponectin and interleukin-10 levels in android obesity: effects of weight loss. Manigrasso, M.R., Ferroni, P., Santilli, F., Taraborelli, T., Guagnano, M.T., Michetti, N., Davì, G. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  39. Lipoprotein(a) in android obesity and NIDDM. Wassef, N., Sidhom, G., Zakareya el-K, n.u.l.l., Mohamed el-K, n.u.l.l. Diabetes Care (1997) [Pubmed]
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