The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ophthalmoscopy


Psychiatry related information on Ophthalmoscopy


High impact information on Ophthalmoscopy

  • All of the CF patients studied had normal fundi on ophthalmoscopy, fundus photographs, and fluorescein angiography [7].
  • Fluorescein angiography allowed the detection of retinopathy, on average, four years earlier than with ophthalmoscopy [8].
  • All these variables were longitudinally evaluated in a cohort of 322 insulin-dependent patients aged 16.2 +/- 4.9 years with diabetes for 7.4 +/- 5.2 years, including those 231 subjects whose eyes were examined once or repeatedly by ophthalmoscopy and fluorescein angiography [9].
  • IR was evaluated by hyperinsulinemic euglycemic clamp; retinopathy was evaluated by indirect ophthalmoscopy and photography [10].
  • OBJECTIVE: To examine incidence and progression of retinopathy using retinal photographs in Pima Indians and to compare the results with those obtained when retinopathy is assessed by direct ophthalmoscopy [11].

Chemical compound and disease context of Ophthalmoscopy


Biological context of Ophthalmoscopy


Anatomical context of Ophthalmoscopy

  • Forty sets of parents and 24 sibs of patients with tuberous sclerosis were investigated by an extensive protocol, including clinical examination of skin, hair, and oral cavity, direct and indirect ophthalmoscopy, cranial CT scan, renal ultrasound, and a radiological skeletal survey [22].
  • Leukocyte dynamics were observed with acridine orange digital fluorography, which uses a nuclear fluorescent dye of acridine orange and scanning laser ophthalmoscopy [23].
  • Clinical examination by indirect ophthalmoscopy indicated an absence of optic nerve congestion and a lower level of vitritis in foscarnet treated animals compared to the untreated group [24].
  • METHODS: The retina and choroid were examined by biomicroscopy, scanning laser ophthalmoscopy, fluorescein and indocyanine green angiography and histology at various times after the surgical removal of the RPE by gentle aspiration following a prior local vitrectomy and bleb detachment [25].
  • METHODS: Twenty-five consecutive patients affected by idiopathic serous pigment epithelium detachment underwent ophthalmoscopy, fluorescein angiography, and indocyanine green videoangiography [26].

Associations of Ophthalmoscopy with chemical compounds

  • At one of two visits, the right eye of each participant underwent two digital imaging modalities: ocular coherence tomography (OCT; StratusOCT; Carl Zeiss Meditec, Dublin, CA) and scanning laser ophthalmoscopy (SLO; Heidelberg Retinal Tomograph; Heidelberg Engineering GmbH, Heidelberg, Germany) [27].
  • Also, there was a trend towards worsening eye lesions, as seen by indirect ophthalmoscopy, in the fluconazole-treated rabbits after 24 days of therapy, which roughly paralleled the quantitative culture results [28].
  • Carbon disulfide effects on the visual system. I. Visual thresholds and ophthalmoscopy [29].
  • After 17 days of therapy, indirect ophthalmoscopy revealed less severe eye involvement in both antifungal treatment groups than in saline controls; however, this difference reached statistical significance only for the amphotericin B-treated rabbits (P less than 0.05) [28].
  • Intravitreal injection of approximately 4 mg of triamcinolone acetonide was performed in one eye of each animal, and eyes were followed clinically for 12 weeks with ophthalmoscopy and fundus photography [30].

Gene context of Ophthalmoscopy

  • PURPOSE: To describe fundus autofluorescence (AF) in carriers of X-linked retinitis pigmentosa (XLRP) associated with mutations in RPGR (RP3), and to compare the findings on AF with ophthalmoscopy and with electrophysiological and psychophysical data [31].
  • METHODS: Eyes of adult mice, homozygous and heterozygous for the p53 gene disruption in the 129/SvJ and C57BL/6J (B6) genetic backgrounds, and their F1 progeny were examined by indirect ophthalmoscopy and by light microscopy [32].
  • Results argue for a combined screening programme for FAP of DNA analysis, indirect ophthalmoscopy and bowel examination [33].
  • RESULTS: Severe (referral-warranted) ROP was diagnosed in 23 eyes by indirect ophthalmoscopy during their series of examinations [34].
  • All dysplastic nevus syndrome patients and their families should be evaluated ophthalmologically, with special attention being given to dilated indirect ophthalmoscopy [35].

Analytical, diagnostic and therapeutic context of Ophthalmoscopy


  1. The WHO multinational study of vascular disease in diabetes: 3. Microvascular disease. Jarrett, R.J., Keen, H. Diabetes Care (1979) [Pubmed]
  2. CD69 expression on peripheral CD4+ T cells parallels disease activity and is reduced by mycophenolate mofetil therapy in uveitis. Kilmartin, D.J., Fletcher, Z.J., Almeida, J.A., Liversidge, J., Forrester, J.V., Dick, A.D. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  3. A hemolysin-encoding plasmid contributes to bacterial virulence in experimental Enterococcus faecalis endophthalmitis. Stevens, S.X., Jensen, H.G., Jett, B.D., Gilmore, M.S. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  4. Diabetic nephropathy in adolescence: appearance during improved glycemic control. Ellis, D., Avner, E.D., Transue, D., Yunis, E.J., Drash, A.L., Becker, D.J. Pediatrics (1983) [Pubmed]
  5. Visual field testing in the management of cytomegalovirus retinitis. Bachman, D.M., Bruni, L.M., DiGioia, R.A., Harris, P.J., McMackin, C.M., Pistole, M.C., Thomas, R.M., Ward, D.J. Ophthalmology (1992) [Pubmed]
  6. Proposed criteria for referring diabetic retinopathy. Collins, J.W. The Nurse practitioner. (1988) [Pubmed]
  7. Quantitative vitreous fluorophotometry in insulin-treated cystic fibrosis patients. Rodman, H.M., Waltman, S.R., Krupin, T., Lee, A.T., Frank, K.E., Matthews, L.W. Diabetes (1983) [Pubmed]
  8. Prevalence and development of retinopathy in children and adolescents with type 1 (insulin-dependent) diabetes mellitus. A longitudinal study. Burger, W., Hövener, G., Düsterhus, R., Hartmann, R., Weber, B. Diabetologia (1986) [Pubmed]
  9. Risk factors for the development of retinopathy in children and adolescents with type 1 (insulin-dependent) diabetes mellitus. Weber, B., Burger, W., Hartmann, R., Hövener, G., Malchus, R., Oberdisse, U. Diabetologia (1986) [Pubmed]
  10. Insulin resistance and proliferative retinopathy: a cross-sectional, case-control study in 115 patients with type 2 diabetes. Parvanova, A., Iliev, I., Filipponi, M., Dimitrov, B.D., Vedovato, M., Tiengo, A., Trevisan, R., Remuzzi, G., Ruggenenti, P. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  11. Longitudinal studies of incidence and progression of diabetic retinopathy assessed by retinal photography in pima indians. Looker, H.C., Krakoff, J., Knowler, W.C., Bennett, P.H., Klein, R., Hanson, R.L. Diabetes Care (2003) [Pubmed]
  12. Choroidal abnormalities in Behçet disease observed by simultaneous indocyanine green and fluorescein angiography with scanning laser ophthalmoscopy. Matsuo, T., Sato, Y., Shiraga, F., Shiragami, C., Tsuchida, Y. Ophthalmology (1999) [Pubmed]
  13. Experimental intravitreal gentamicin. Zachary, I.G., Forster, R.K. Am. J. Ophthalmol. (1976) [Pubmed]
  14. Inhibition of diclofenac formulated in hyaluronan on angiogenesis in vitro and its intraocular tolerance in the rabbit eye. Shen, W.Y., Constable, I.J., Chelva, E., Rakoczy, P.E. Graefes Arch. Clin. Exp. Ophthalmol. (2000) [Pubmed]
  15. Intravitreal toxicity of moxifloxacin. Aydin, E., Kazi, A.A., Peyman, G.A., Esfahani, M.R. Retina (Philadelphia, Pa.) (2006) [Pubmed]
  16. Intravitreal toxicity of garenoxacin. Esfahani, M.R., Kazi, A.A., Peyman, G.A., Dellacroce, J.T., Aydin, E. Retina (Philadelphia, Pa.) (2006) [Pubmed]
  17. Macular circulation and the flying corpuscles phenomenon. Loebl, M., Riva, C.E. Ophthalmology (1978) [Pubmed]
  18. Fundus lesions in malignant hypertension. III. Arterial blood pressure, biochemical, and fundus changes. Hayreh, S.S., Servais, G.E., Virdi, P.S., Marcus, M.L., Rojas, P., Woolson, R.F. Ophthalmology (1986) [Pubmed]
  19. Tolerance of human fetal retinal pigment epithelium xenografts in monkey retina. Berglin, L., Gouras, P., Sheng, Y., Lavid, J., Lin, P.K., Cao, H., Kjeldbye, H. Graefes Arch. Clin. Exp. Ophthalmol. (1997) [Pubmed]
  20. Clinical analysis of Leber's hereditary optic neuropathy harboring mtDNA mutation at nt11778. Zhang, X., Yu, Q., Zhang, Q., Yi, C. Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu. (2001) [Pubmed]
  21. Hypofluorescent spots on indocyanine green angiography at the recovery stage in multiple evanescent white dot syndrome. Tsukamoto, E., Yamada, T., Kadoi, C., Hayasaka, S., Nagaki, Y., Hayasaka, Y. Ophthalmologica (1999) [Pubmed]
  22. The value of investigation for genetic counselling in tuberous sclerosis. Fryer, A.E., Chalmers, A.H., Osborne, J.P. J. Med. Genet. (1990) [Pubmed]
  23. Interferon alfa induces leukocyte capillary trapping in rat retinal microcirculation. Nishiwaki, H., Ogura, Y., Miyamoto, K., Matsuda, N., Honda, Y. Arch. Ophthalmol. (1996) [Pubmed]
  24. Reducing chorioretinal viral counts with intravitreal foscarnet injections in a rabbit model of Herpes simplex virus type-1 retinitis. Morin, N.J., Delorme, C., Gourde, P., Omar, R.F., Désormeaux, A., Tremblay, M.J., Beauchamp, D., Rousseau, A., Bergeron, M.G. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1999) [Pubmed]
  25. Changes in the choroidal circulation of rabbit following RPE removal. Ivert, L., Kong, J., Gouras, P. Graefes Arch. Clin. Exp. Ophthalmol. (2003) [Pubmed]
  26. Choroidal findings in the course of idiopathic serous pigment epithelium detachment detected by indocyanine green videoangiography. Giovannini, A., Scassellati-Sforzolini, B., D'Altobrando, E., Mariotti, C., Rutili, T., Tittarelli, R. Retina (Philadelphia, Pa.) (1997) [Pubmed]
  27. Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer. Wild, J.M., Robson, C.R., Jones, A.L., Cunliffe, I.A., Smith, P.E. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  28. Comparison of fluconazole and amphotericin B for treatment of disseminated candidiasis and endophthalmitis in rabbits. Filler, S.G., Crislip, M.A., Mayer, C.L., Edwards, J.E. Antimicrob. Agents Chemother. (1991) [Pubmed]
  29. Carbon disulfide effects on the visual system. I. Visual thresholds and ophthalmoscopy. Merigan, W.H., Wood, R.W., Zehl, D., Eskin, T.A. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  30. Inhibition of preretinal and optic nerve head neovascularization in pigs by intravitreal triamcinolone acetonide. Danis, R.P., Bingaman, D.P., Yang, Y., Ladd, B. Ophthalmology (1996) [Pubmed]
  31. Fundus autofluorescence in carriers of X-linked recessive retinitis pigmentosa associated with mutations in RPGR, and correlation with electrophysiological and psychophysical data. Wegscheider, E., Preising, M.N., Lorenz, B. Graefes Arch. Clin. Exp. Ophthalmol. (2004) [Pubmed]
  32. Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice. Ikeda, S., Hawes, N.L., Chang, B., Avery, C.S., Smith, R.S., Nishina, P.M. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  33. Role of congenital hypertrophy of the retinal pigment epithelium in the predictive diagnosis of familial adenomatous polyposis. Morton, D.G., Gibson, J., Macdonald, F., Brown, R., Haydon, J., Cullen, R., Rindl, M., Hulten, M., Neoptolemos, J.P., Keighley, M.R. The British journal of surgery. (1992) [Pubmed]
  34. Telemedicine approach to screening for severe retinopathy of prematurity: a pilot study. Ells, A.L., Holmes, J.M., Astle, W.F., Williams, G., Leske, D.A., Fielden, M., Uphill, B., Jennett, P., Hebert, M. Ophthalmology (2003) [Pubmed]
  35. Ocular findings in patients with dysplastic nevus syndrome. Rodriguez-Sains, R.S. Ophthalmology (1986) [Pubmed]
  36. Progressive retinal atrophy in the Abyssinian cat. Clinical characteristics. Narfström, K. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  37. Experimental macular edema after lens extraction. Tso, M.O., Shih, C.Y. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  38. A new model of subretinal neovascularization in the rabbit. Kimura, H., Sakamoto, T., Hinton, D.R., Spee, C., Ogura, Y., Tabata, Y., Ikada, Y., Ryan, S.J. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  39. Photodynamic therapy for symptomatic choroidal hemangioma: visual and anatomic results. Schmidt-Erfurth, U.M., Michels, S., Kusserow, C., Jurklies, B., Augustin, A.J. Ophthalmology (2002) [Pubmed]
  40. Angiographic and histologic effects of fundus photodynamic therapy with a hydrophilic sensitizer (mono-L-aspartyl chlorin e6). Mori, K., Yoneya, S., Ohta, M., Sano, A., Anzai, K., Peyman, G.A., Moshfeghi, D.M. Ophthalmology (1999) [Pubmed]
WikiGenes - Universities