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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Ophthalmoscopy

 
 
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Disease relevance of Ophthalmoscopy

 

Psychiatry related information on Ophthalmoscopy

 

High impact information on Ophthalmoscopy

  • All of the CF patients studied had normal fundi on ophthalmoscopy, fundus photographs, and fluorescein angiography [7].
  • Fluorescein angiography allowed the detection of retinopathy, on average, four years earlier than with ophthalmoscopy [8].
  • All these variables were longitudinally evaluated in a cohort of 322 insulin-dependent patients aged 16.2 +/- 4.9 years with diabetes for 7.4 +/- 5.2 years, including those 231 subjects whose eyes were examined once or repeatedly by ophthalmoscopy and fluorescein angiography [9].
  • IR was evaluated by hyperinsulinemic euglycemic clamp; retinopathy was evaluated by indirect ophthalmoscopy and photography [10].
  • OBJECTIVE: To examine incidence and progression of retinopathy using retinal photographs in Pima Indians and to compare the results with those obtained when retinopathy is assessed by direct ophthalmoscopy [11].
 

Chemical compound and disease context of Ophthalmoscopy

 

Biological context of Ophthalmoscopy

 

Anatomical context of Ophthalmoscopy

  • Forty sets of parents and 24 sibs of patients with tuberous sclerosis were investigated by an extensive protocol, including clinical examination of skin, hair, and oral cavity, direct and indirect ophthalmoscopy, cranial CT scan, renal ultrasound, and a radiological skeletal survey [22].
  • Leukocyte dynamics were observed with acridine orange digital fluorography, which uses a nuclear fluorescent dye of acridine orange and scanning laser ophthalmoscopy [23].
  • Clinical examination by indirect ophthalmoscopy indicated an absence of optic nerve congestion and a lower level of vitritis in foscarnet treated animals compared to the untreated group [24].
  • METHODS: The retina and choroid were examined by biomicroscopy, scanning laser ophthalmoscopy, fluorescein and indocyanine green angiography and histology at various times after the surgical removal of the RPE by gentle aspiration following a prior local vitrectomy and bleb detachment [25].
  • METHODS: Twenty-five consecutive patients affected by idiopathic serous pigment epithelium detachment underwent ophthalmoscopy, fluorescein angiography, and indocyanine green videoangiography [26].
 

Associations of Ophthalmoscopy with chemical compounds

  • At one of two visits, the right eye of each participant underwent two digital imaging modalities: ocular coherence tomography (OCT; StratusOCT; Carl Zeiss Meditec, Dublin, CA) and scanning laser ophthalmoscopy (SLO; Heidelberg Retinal Tomograph; Heidelberg Engineering GmbH, Heidelberg, Germany) [27].
  • Also, there was a trend towards worsening eye lesions, as seen by indirect ophthalmoscopy, in the fluconazole-treated rabbits after 24 days of therapy, which roughly paralleled the quantitative culture results [28].
  • Carbon disulfide effects on the visual system. I. Visual thresholds and ophthalmoscopy [29].
  • After 17 days of therapy, indirect ophthalmoscopy revealed less severe eye involvement in both antifungal treatment groups than in saline controls; however, this difference reached statistical significance only for the amphotericin B-treated rabbits (P less than 0.05) [28].
  • Intravitreal injection of approximately 4 mg of triamcinolone acetonide was performed in one eye of each animal, and eyes were followed clinically for 12 weeks with ophthalmoscopy and fundus photography [30].
 

Gene context of Ophthalmoscopy

  • PURPOSE: To describe fundus autofluorescence (AF) in carriers of X-linked retinitis pigmentosa (XLRP) associated with mutations in RPGR (RP3), and to compare the findings on AF with ophthalmoscopy and with electrophysiological and psychophysical data [31].
  • METHODS: Eyes of adult mice, homozygous and heterozygous for the p53 gene disruption in the 129/SvJ and C57BL/6J (B6) genetic backgrounds, and their F1 progeny were examined by indirect ophthalmoscopy and by light microscopy [32].
  • Results argue for a combined screening programme for FAP of DNA analysis, indirect ophthalmoscopy and bowel examination [33].
  • RESULTS: Severe (referral-warranted) ROP was diagnosed in 23 eyes by indirect ophthalmoscopy during their series of examinations [34].
  • All dysplastic nevus syndrome patients and their families should be evaluated ophthalmologically, with special attention being given to dilated indirect ophthalmoscopy [35].
 

Analytical, diagnostic and therapeutic context of Ophthalmoscopy

References

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  19. Tolerance of human fetal retinal pigment epithelium xenografts in monkey retina. Berglin, L., Gouras, P., Sheng, Y., Lavid, J., Lin, P.K., Cao, H., Kjeldbye, H. Graefes Arch. Clin. Exp. Ophthalmol. (1997) [Pubmed]
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  21. Hypofluorescent spots on indocyanine green angiography at the recovery stage in multiple evanescent white dot syndrome. Tsukamoto, E., Yamada, T., Kadoi, C., Hayasaka, S., Nagaki, Y., Hayasaka, Y. Ophthalmologica (1999) [Pubmed]
  22. The value of investigation for genetic counselling in tuberous sclerosis. Fryer, A.E., Chalmers, A.H., Osborne, J.P. J. Med. Genet. (1990) [Pubmed]
  23. Interferon alfa induces leukocyte capillary trapping in rat retinal microcirculation. Nishiwaki, H., Ogura, Y., Miyamoto, K., Matsuda, N., Honda, Y. Arch. Ophthalmol. (1996) [Pubmed]
  24. Reducing chorioretinal viral counts with intravitreal foscarnet injections in a rabbit model of Herpes simplex virus type-1 retinitis. Morin, N.J., Delorme, C., Gourde, P., Omar, R.F., Désormeaux, A., Tremblay, M.J., Beauchamp, D., Rousseau, A., Bergeron, M.G. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1999) [Pubmed]
  25. Changes in the choroidal circulation of rabbit following RPE removal. Ivert, L., Kong, J., Gouras, P. Graefes Arch. Clin. Exp. Ophthalmol. (2003) [Pubmed]
  26. Choroidal findings in the course of idiopathic serous pigment epithelium detachment detected by indocyanine green videoangiography. Giovannini, A., Scassellati-Sforzolini, B., D'Altobrando, E., Mariotti, C., Rutili, T., Tittarelli, R. Retina (Philadelphia, Pa.) (1997) [Pubmed]
  27. Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer. Wild, J.M., Robson, C.R., Jones, A.L., Cunliffe, I.A., Smith, P.E. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
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  29. Carbon disulfide effects on the visual system. I. Visual thresholds and ophthalmoscopy. Merigan, W.H., Wood, R.W., Zehl, D., Eskin, T.A. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  30. Inhibition of preretinal and optic nerve head neovascularization in pigs by intravitreal triamcinolone acetonide. Danis, R.P., Bingaman, D.P., Yang, Y., Ladd, B. Ophthalmology (1996) [Pubmed]
  31. Fundus autofluorescence in carriers of X-linked recessive retinitis pigmentosa associated with mutations in RPGR, and correlation with electrophysiological and psychophysical data. Wegscheider, E., Preising, M.N., Lorenz, B. Graefes Arch. Clin. Exp. Ophthalmol. (2004) [Pubmed]
  32. Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice. Ikeda, S., Hawes, N.L., Chang, B., Avery, C.S., Smith, R.S., Nishina, P.M. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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