Disease relevance of Discitis

• Successful treatment of Aspergillus spondylodiscitis with high-dose itraconazole in a patient with acute myelogenous leukemia [1].
• CONCLUSION: Image-guided PD in conjunction with antituberculous drug therapy is an effective and safe procedure in the treatment of tuberculous iliopsoas abscesses with or without spondylodiskitis [2].
• These radiological findings are similar to the discovertebral changes of spondylodiscitis in ankylosing spondylitis, thus giving support to the relations between SAPHO syndrome and spondylarthropathies [3].
• CONCLUSIONS: Discitis and/or osteomyelitis occurs in HIV-positive patients with a mild-to-moderate decrease (>/=200 cells/mm(3)) in the CD4 T-cell count, and the infection responds to appropriate antibiotics [4].
• Retrospective study including 9 patients with aspergillus discitis, in which 7 were immunosuppressed; 3 were heart transplant patients, 2 had acute lymphoblastic leukemia, 1 hairy cell leukemia and one was receiving prednisone for bronchial asthma [5].

High impact information on Discitis

• This entire triad of findings, which is strongly suggestive of postoperative diskitis, was not seen in any of the asymptomatic patients [6].
• A 62-year-old man with amphotericin B-resistant Candida krusei spondylodiscitis, following an episode of candidemia caused by the same strain, was successfully treated with caspofungin plus voriconazole [7].
• FDG-PET/CT scan of inflammatory spondylodiscitis lesions in ankylosing spondylitis, and short term evolution during anti-tumour necrosis factor treatment [8].
• Aseptic psoas pyomyositis and erosive discitis in a case of calcium pyrophosphate crystal deposition disease [9].
• The preliminary results of treating candidal spondylodiskitis with triazole derivatives, particularly fluconazole, were satisfactory; there was excellent tolerance of this drug [10].

Chemical compound and disease context of Discitis

• Role of technetium-99m diphosphonate and gallium-67 citrate bone scanning in the early diagnosis of infectious spondylodiscitis. A comparative study [11].
• Discitis caused by the Centers for Disease Control microorganism Group Ve-1 [12].
• After drawing back the needle, cephazolin 50 mg in 1 mL was administered to the disc to prevent discitis [13].
• Gentamicin-containing collagenous sponges placed in the cleared disc space were effective in preventing postoperative spondylodiscitis [14].
• Spondylodiscitis involving C6, C7, and the intervening vertebral disk with medullary compression was detected by means of imaging studies [15].

Anatomical context of Discitis

• The SFA stent-graft occlusion required femoropopliteal bypass; the abscess and spondylodiskitis that had developed in the T12 and L1 vertebrae responded to intravenous antibiotics [16].
• The diagnosis of spondylodiscitis after lumbar disc surgery has been based so far on clinical abnormalities, non-specific changes in chemical laboratory parameters [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)] and radiological examinations such as MRI [17].

Gene context of Discitis

• A destructive discovertebral lesion: septic discitis, ankylosing spondylitis, or rheumatoid arthritis [18]?
• The clinical findings and results of CRP and MRI suggested an aseptic spondylodiscitis due to chymodiactin [19].
• The ESR, a sensitive measure of the inflammatory response, is elevated in 90% of patients who have serious orthopedic infections, e.g., discitis, septic arthritis, and hematogenous osteomyelitis [20].
• RESULTS: Disc puncture was performed without difficulty in all patients, there were no complications associated with disc puncture such as discitis or disc rupture [13].
• CONCLUSIONS: Severe neck pain after tracheoesophageal puncture should alert the physician about the possibility of a cervical spondylodiscitis [15].

Analytical, diagnostic and therapeutic context of Discitis

• OBJECTIVES: To report the incidence of postoperative spondylodiscitis in cases in which no antibiotic prophylaxis was used, and to define the value of a collagenous sponge containing gentamicin in preventing disc space infections [14].
• Fluorine-18 fluorodeoxyglucose positron emission tomography findings in spondylodiscitis: preliminary results [21].
• Diagnosis of discitis by SPECT technetium-99m MDP scintigram. A case report [22].
• Twelve cases of intervertebral discitis following lumbar discectomy were evaluated and ESR was assessed in 70 patients operated on and without evidence of postoperative infection [23].

References