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Chemical Compound Review

Gallium-67     gallium

Synonyms: AC1NUYXW, 67Ga, 14119-09-6, Gallium, isotope of mass 67
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Disease relevance of gallium


Psychiatry related information on gallium


High impact information on gallium


Chemical compound and disease context of gallium


Biological context of gallium


Anatomical context of gallium


Associations of gallium with other chemical compounds


Gene context of gallium

  • Uptake of gallium-67 by human leukemic cells: demonstration of transferrin receptor-dependent and transferrin-independent mechanisms [30].
  • Patients with positive gallium-67 uptake or bilateral hilar lymphadenopathy had high levels of either serum IFN-gamma or lysozyme [31].
  • The patients positive for gallium-67 ((67)Ga) scan had significantly elevated serum IL-18 levels as compared with those of the negative patients [32].
  • Gallium-67/gallium-68-[DFO]-octreotide--a potential radiopharmaceutical for PET imaging of somatostatin receptor-positive tumors: synthesis and radiolabeling in vitro and preliminary in vivo studies [33].
  • In one patient, a lesion in the femur, which was detected by computed tomography (CT) and gallium-67 scans, was also seen on the CD19 scan from 1 h after administration of the radioimmunoconjugate onwards [34].

Analytical, diagnostic and therapeutic context of gallium


  1. Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members. Bitterman, P.B., Rennard, S.I., Keogh, B.A., Wewers, M.D., Adelberg, S., Crystal, R.G. N. Engl. J. Med. (1986) [Pubmed]
  2. Gallium 67 scans in small cell carcinoma. Bitran, J.D., Bekerman, C., Pinsky, S., DeMesteer, T., Golomb, H.M. JAMA (1979) [Pubmed]
  3. Empyema seven years after pneumonectomy. Detection by Gallium 67 scan. Kutty, C.P., Varkey, B. JAMA (1979) [Pubmed]
  4. Gallium-67 imaging in patients with dilated cardiomyopathy and biopsy-proven myocarditis. O'Connell, J.B., Henkin, R.E., Robinson, J.A., Subramanian, R., Scanlon, P.J., Gunnar, R.M. Circulation (1984) [Pubmed]
  5. Immunosuppressive therapy in patients with congestive cardiomyopathy and myocardial uptake of gallium-67. O'Connell, J.B., Robinson, J.A., Henkin, R.E., Gunnar, R.M. Circulation (1981) [Pubmed]
  6. Comparison of bone and gallium-67 imaging in heroin users' arthritis. Bittini, A., Dominguez, P.L., Martinez Pueyo, M.L., López Longo, F.J., Monteagudo, I., Carreño, L. J. Nucl. Med. (1985) [Pubmed]
  7. Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report. Teixeira, A.B., Etchebehere, E.C., Lima, M.C., Santos, A.O., Pires, B.C., Valença, J.T., Ramos, C.D., Camargo, E.E. Rev. Inst. Med. Trop. Sao Paulo (2000) [Pubmed]
  8. Gallium-67 detection of intramammary injection sites secondary to intravenous drug abuse. Swayne, L.C. Clinical nuclear medicine. (1989) [Pubmed]
  9. Common pathway for tumor cell uptake of gallium-67 and iron-59 via a transferrin receptor. Larson, S.M., Rasey, J.S., Allen, D.R., Nelson, N.J., Grunbaum, Z., Harp, G.D., Williams, D.L. J. Natl. Cancer Inst. (1980) [Pubmed]
  10. Muscles undergoing physiological adaptation to stress take up gallium-67 citrate. O'Connell, J.B., Robinson, J.A., Henkin, R.E., Messmore, H.L. Lancet (1980) [Pubmed]
  11. Gallium-67 imaging in cardiomyopathy. Robinson, J.A., O'Connell, J., Henkin, R.E., Gunnar, R.M. Ann. Intern. Med. (1979) [Pubmed]
  12. Utility of gallium-67 scintigraphy in low-grade non-Hodgkin's lymphoma. Ben-Haim, S., Bar-Shalom, R., Israel, O., Haim, N., Epelbaum, R., Ben-Shachar, M., Gaitini, D., Kolodny, G.M., Front, D. J. Clin. Oncol. (1996) [Pubmed]
  13. Gallium-67 scan for distinguishing follicular hyperplasia from other AIDS-associated diseases in lymph nodes. Podzamczer, D., Ricart, I., Bolao, F., Romagosa, V., Bonnin, D., Guionnet, N., Gudiol, F. AIDS (1990) [Pubmed]
  14. Fluorine-18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin's disease and non-Hodgkin's lymphoma. Wirth, A., Seymour, J.F., Hicks, R.J., Ware, R., Fisher, R., Prince, M., MacManus, M.P., Ryan, G., Januszewicz, H., Wolf, M. Am. J. Med. (2002) [Pubmed]
  15. Thallium-201 scintigraphy for assessment of a gallium-67-avid mediastinal mass following therapy for Hodgkin's disease. Harris, E.W., Rakow, J.I., Weiner, M., Agress, H. J. Nucl. Med. (1993) [Pubmed]
  16. Gallium-67 in the evaluation of sarcoidosis: correlations with serum angiotensin-converting enzyme and bronchoalveolar lavage. Beaumont, D., Herry, J.Y., Sapene, M., Bourguet, P., Larzul, J.J., de Labarthe, B. Thorax (1982) [Pubmed]
  17. Radiographic and radionuclide imaging in multiple myeloma: the role of gallium scintigraphy: concise communication. Waxman, A.D., Siemsen, J.K., Levine, A.M., Holdorf, D., Suzuki, R., Singer, F.R., Bateman, J. J. Nucl. Med. (1981) [Pubmed]
  18. High frequency of benign mediastinal uptake of gallium-67 after completion of chemotherapy in children with high-grade non-Hodgkin's lymphoma. Peylan-Ramu, N., Haddy, T.B., Jones, E., Horvath, K., Adde, M.A., Magrath, I.T. J. Clin. Oncol. (1989) [Pubmed]
  19. Difference in gallium-67 tissue distribution in male and female mice. Chilton, H.M., Witcofski, R.L., Heise, C.M. J. Nucl. Med. (1981) [Pubmed]
  20. Uptake of gallium-67 in transfected cells and tumors absent or enriched in the transferrin receptor. Luttropp, C.A., Jackson, J.A., Jones, B.J., Sohn, M.H., Lynch, R.E., Morton, K.A. J. Nucl. Med. (1998) [Pubmed]
  21. Corticosteroid treatment in pulmonary sarcoidosis: do serial lavage lymphocyte counts, serum angiotensin converting enzyme measurements, and gallium-67 scans help management? Turner-Warwick, M., McAllister, W., Lawrence, R., Britten, A., Haslam, P.L. Thorax (1986) [Pubmed]
  22. Role of iron-binding proteins and enhanced capillary permeability on the accumulation of gallium-67. Tzen, K.Y., Oster, Z.H., Wagner, H.N., Tsan, M.F. J. Nucl. Med. (1980) [Pubmed]
  23. Role of magnetic resonance imaging in predicting relapse in residual masses after treatment of lymphoma. Hill, M., Cunningham, D., MacVicar, D., Roldan, A., Husband, J., McCready, R., Mansi, J., Milan, S., Hickish, T. J. Clin. Oncol. (1993) [Pubmed]
  24. Detection of myocarditis during the first year after discovery of a dilated cardiomyopathy by endomyocardial biopsy and gallium-67 myocardial scintigraphy: prospective multicentre French study of 91 patients. Bouhour, J.B., Helias, J., de Lajartre, A.Y., Petitier, H., Komajda, M., Leger, A., Delcourt, A., Sacrez, A., Bareiss, P., Constantinesco, A. Eur. Heart J. (1988) [Pubmed]
  25. Indium-111-leukocyte and gallium-67 imaging in acute sarcoidosis: report of two patients. Palestro, C.J., Schultz, B., Horowitz, M., Swyer, A.J. J. Nucl. Med. (1992) [Pubmed]
  26. Computerized double-tracer subtraction scanning with gallium-67 citrate in inflammatory diseases. Dhawan, V.M., Sziklas, J.J., Spencer, R.P., Rich, D.A. J. Nucl. Med. (1978) [Pubmed]
  27. Will thallium-201 replace gallium-67 in salivary gland scintigraphy? Arbab, A.S., Koizumi, K., Hiraike, S., Toyama, K., Arai, T., Araki, T. J. Nucl. Med. (1996) [Pubmed]
  28. Role of phosphate-containing compounds in the transfer of indium-111 and gallium-67 from transferrin to ferritin. Weiner, R.E. J. Nucl. Med. (1989) [Pubmed]
  29. The effect of methylene diphosphonate on the tissue distribution of gallium-67. Downing, D., Aburano, T., Bushberg, J., Hoffer, P.B. J. Nucl. Med. (1985) [Pubmed]
  30. Uptake of gallium-67 by human leukemic cells: demonstration of transferrin receptor-dependent and transferrin-independent mechanisms. Chitambar, C.R., Zivkovic, Z. Cancer Res. (1987) [Pubmed]
  31. Detection of endogenous cytokines in sera or in lymph nodes obtained from patients with sarcoidosis. Asano, M., Minagawa, T., Ohmichi, M., Hiraga, Y. Clin. Exp. Immunol. (1991) [Pubmed]
  32. Increased levels of interleukin-18 in patients with pulmonary sarcoidosis. Shigehara, K., Shijubo, N., Ohmichi, M., Yamada, G., Takahashi, R., Okamura, H., Kurimoto, M., Hiraga, Y., Tatsuno, T., Abe, S., Sato, N. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  33. Gallium-67/gallium-68-[DFO]-octreotide--a potential radiopharmaceutical for PET imaging of somatostatin receptor-positive tumors: synthesis and radiolabeling in vitro and preliminary in vivo studies. Smith-Jones, P.M., Stolz, B., Bruns, C., Albert, R., Reist, H.W., Fridrich, R., Mäcke, H.R. J. Nucl. Med. (1994) [Pubmed]
  34. 99mTc-CD19 monoclonal antibody is not useful for imaging of B cell non-Hodgkin's lymphoma. Vervoordeldonk, S.F., Heikens, J., Goedemans, W.T., Merle, P.A., von dem Borne, A.E., van Royen, E.A., Slaper-Cortenbach, I.C., van Oers, R.H. Cancer Immunol. Immunother. (1996) [Pubmed]
  35. Tracer feasibility for monitoring tumor radiotherapy: a quadruple tracer study with fluorine-18-fluorodeoxyglucose or fluorine-18-fluorodeoxyuridine, L-[methyl-14C]methionine, [6-3H]thymidine, and gallium-67. Kubota, K., Ishiwata, K., Kubota, R., Yamada, S., Tada, M., Sato, T., Ido, T. J. Nucl. Med. (1991) [Pubmed]
  36. Interstitial pulmonary fibrosis with and without associated collagen vascular disease: results of a two year follow up. Agustí, C., Xaubet, A., Roca, J., Agustí, A.G., Rodriguez-Roisin, R. Thorax (1992) [Pubmed]
  37. Comparison of computed tomography, ultrasonography, and gallium-67 scanning in the evaluation of suspected abdominal abscess. Korobkin, M., Callen, P.W., Filly, R.A., Hoffer, P.B., Shimshak, R.R., Kressel, H.Y. Radiology. (1978) [Pubmed]
  38. Early diagnosis of disc-space infection using Gallium-67. Norris, S., Ehrlich, M.G., Keim, D.E., Guiterman, H., McKusick, K.A. J. Nucl. Med. (1978) [Pubmed]
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