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MeSH Review

Genes, erbA

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Disease relevance of Genes, erbA


High impact information on Genes, erbA


Biological context of Genes, erbA


Anatomical context of Genes, erbA


Associations of Genes, erbA with chemical compounds

  • It consists of 930 amino acids and contains a basic, cysteine-rich region (residues 568-645) with extensive homology to the glucocorticoid and estrogen receptors and the v-erbA oncogene protein [16].
  • Thus, v-ski cooperates with tyrosine kinase oncogenes in a similar fashion to the v-erbA oncogene, however the pattern of genes affected by these two oncogenes is different [17].
  • The v-erbA oncogene blocks expression of alpha2/beta1 integrin a normal inhibitor of erythroid progenitor proliferation [18].
  • The well documented mitogenic and hormone regulatory effects of estrogen (E2) on pituitary cells are mediated via its nuclear receptor (ER), a cellular homolog of v-erbA oncogene [19].
  • The v-erbA oncogene of avian erythroblastosis virus is derived from a cellular gene for a thyroid hormone (T4/T3 thyronine) receptor and encodes a DNA-binding protein found principally in the nucleus of the infected cell [20].

Gene context of Genes, erbA


  1. Thyroid hormone receptor homodimers can function as ligand-sensitive repressors. Piedrafita, F.J., Bendik, I., Ortiz, M.A., Pfahl, M. Mol. Endocrinol. (1995) [Pubmed]
  2. Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Stevens, D.A., Harvey, C.B., Scott, A.J., O'Shea, P.J., Barnard, J.C., Williams, A.J., Brady, G., Samarut, J., Chassande, O., Williams, G.R. Mol. Endocrinol. (2003) [Pubmed]
  3. Cloning and expression in Escherichia coli of the homoserine kinase (thrB) gene from Brevibacterium lactofermentum. Mateos, L.M., del Real, G., Aguilar, A., Martín, J.F. Mol. Gen. Genet. (1987) [Pubmed]
  4. A novel mechanism of action for v-ErbA: abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors. Desbois, C., Aubert, D., Legrand, C., Pain, B., Samarut, J. Cell (1991) [Pubmed]
  5. v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action. Sharif, M., Privalsky, M.L. Cell (1991) [Pubmed]
  6. v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Zenke, M., Muñoz, A., Sap, J., Vennström, B., Beug, H. Cell (1990) [Pubmed]
  7. Sequence and expression of human estrogen receptor complementary DNA. Greene, G.L., Gilna, P., Waterfield, M., Baker, A., Hort, Y., Shine, J. Science (1986) [Pubmed]
  8. A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library. Benbrook, D., Pfahl, M. Science (1987) [Pubmed]
  9. Thyroid hormone receptor/c-erbA: control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12. Muñoz, A., Wrighton, C., Seliger, B., Bernal, J., Beug, H. J. Cell Biol. (1993) [Pubmed]
  10. Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. Barlow, C., Meister, B., Lardelli, M., Lendahl, U., Vennström, B. EMBO J. (1994) [Pubmed]
  11. Characterization of the mouse rod transducin alpha subunit gene. Raport, C.J., Dere, B., Hurley, J.B. J. Biol. Chem. (1989) [Pubmed]
  12. c-erbA alpha/T3R and RARs control commitment of hematopoietic self-renewing progenitor cells to apoptosis or differentiation and are antagonized by the v-erbA oncogene. Gandrillon, O., Ferrand, N., Michaille, J.J., Roze, L., Zile, M.H., Samarut, J. Oncogene (1994) [Pubmed]
  13. Expression of the v-erbA product, an altered nuclear hormone receptor, is sufficient to transform erythrocytic cells in vitro. Gandrillon, O., Jurdic, P., Pain, B., Desbois, C., Madjar, J.J., Moscovici, M.G., Moscovici, C., Samarut, J. Cell (1989) [Pubmed]
  14. Compensatory role of thyroid hormone receptor (TR) alpha 1 in resistance to thyroid hormone: study in mice with a targeted mutation in the TR beta gene and deficient in TR alpha 1. Suzuki, H., Cheng, S.Y. Mol. Endocrinol. (2003) [Pubmed]
  15. v-erbA oncogene induces invasiveness and anchorage-independent growth in cultured glial cells by mechanisms involving platelet-derived growth factor. Llanos, S., Iglesias, T., Riese, H.H., Garrido, T., Caelles, C., Muñoz, A. Cell Growth Differ. (1996) [Pubmed]
  16. Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA. Loosfelt, H., Atger, M., Misrahi, M., Guiochon-Mantel, A., Meriel, C., Logeat, F., Benarous, R., Milgrom, E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  17. The v-ski oncogene cooperates with the v-sea oncogene in erythroid transformation by blocking erythroid differentiation. Larsen, J., Beug, H., Hayman, M.J. Oncogene (1992) [Pubmed]
  18. The v-erbA oncogene blocks expression of alpha2/beta1 integrin a normal inhibitor of erythroid progenitor proliferation. Mey, A., Gandrillon, O., McNagny, K.M., Clegg, D.O., Samarut, J. Oncogene (2002) [Pubmed]
  19. Tumor-specific expression of alternatively spliced estrogen receptor messenger ribonucleic acid variants in human pituitary adenomas. Chaidarun, S.S., Klibanski, A., Alexander, J.M. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  20. A subpopulation of the avian erythroblastosis virus v-erbA protein, a member of the nuclear hormone receptor family, is glycosylated. Privalsky, M.L. J. Virol. (1990) [Pubmed]
  21. Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the retinoblastoma gene. Szpirer, C., Szpirer, J., Rivière, M., Ingvarsson, S., Vennström, B., Islam, M.Q., Levan, G. Oncogene (1991) [Pubmed]
  22. Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor. Weiss, R.E., Hayashi, Y., Nagaya, T., Petty, K.J., Murata, Y., Tunca, H., Seo, H., Refetoff, S. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  23. The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. Krust, A., Green, S., Argos, P., Kumar, V., Walter, P., Bornert, J.M., Chambon, P. EMBO J. (1986) [Pubmed]
  24. Evidence for an internal promoter in the Escherichia coli threonine operon. Saint Girons, I., Margarita, D. J. Bacteriol. (1985) [Pubmed]
  25. Thyroid hormone receptors/THR genes in human cancer. González-Sancho, J.M., García, V., Bonilla, F., Muñoz, A. Cancer Lett. (2003) [Pubmed]
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